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 NM  Vol.3 No.2 , June 2012
Modification of the Brief Smell Identification Test by Introduction of a Placebo
Abstract: Objective: To introduce the concept that there might be “nothing to smell” to the Brief Smell Identification Test (B-SIT), with a view to masking olfactory deficits, particularly from healthy control participants in research studies. Methods: Seventy-one elderly individuals, healthy for their age, were recruited to the study. They were blindfolded and carried out a modified B-SIT where one item had been replaced with a placebo, and one odour alternative answer to three other items was replaced by the alternative “none/other” (actual odour unchanged). Results: There was no overall difference in the median or mean score achieved by the cohort compared to results obtained previously using the conventional B-SIT. The replacement of the item “turpentine” with a placebo resulted in an improved score for the item in a Norwegian setting. The overall scores were not improved. Conclusions: It is possible to introduce the concept that there may be “nothing to smell” to the B-SIT without compromising the test for healthy control individuals. This may be a more appropriate approach to olfactory testing of control individuals or patients with suspected early neurodegenerative diseases.
Cite this paper: G. Kjelvik, O. Bosnes, R. Omli, L. Heidi Skotnes, A. K. Håberg and L. R. White, "Modification of the Brief Smell Identification Test by Introduction of a Placebo," Neuroscience and Medicine, Vol. 3 No. 2, 2012, pp. 125-129. doi: 10.4236/nm.2012.32017.
References

[1]   C. Hawkes, “Olfaction in Neurodegenerative Disorder,” Advances in Oto-Rhino-Laryngology, Vol. 63, 2006, pp. 133-151. doi:10.1159/000093759

[2]   T. Kovacs, “Mechanisms of Olfactory Dysfunction in Aging and Neurodegenerative Disorders,” Ageing Research Reviews, Vol. 3, No. 2, 2004, pp. 215-232. doi:10.1016/j.arr.2003.10.003

[3]   R. L. Doty, “The Brief Smell Identification Test Admninstrator Manual,” Sensonics Inc., Haddon Heights, 2001.

[4]   G. Kjelvik, S. B. Sando, J. Aasly, K. A. Engedal and L. R. White, “ Use of the Brief Smell Identification Test for Olfactory Deficit in a Norwegian Population with Alzheimer’s Disease,” International Journal of Geriatric Psychiatry, Vol. 22, No. 10, 2007, pp. 1020-1024. doi:10.1002/gps.1783

[5]   D. Wechsler, “Wechsler Memory Scale, Third Edition, WMS-III,” The Psychological Cooperation, San Antonio, 1997.

[6]   D. Wechsler, “Wechsler Adult Intelligence Scale, Third Edition, WMS-III,” The Psychological Cooperation, San Antonio, 1997.

[7]   R. S. Wilson, S. E. Arnold, J. A. Schneider, P. A. Boyle, A. S. Buchman and D. A. Bennett, “Olfactory Impairment in Presymptomatic Alzheimer’s Disease,” Annals of the New York Academy of Sciences, Vol. 1170, 2009, pp. 730-735. doi:10.1111/j.1749-6632.2009.04013.x

[8]   G. E. Swan and D. Carmelli, “Impaired Olfaction Predicts Cognitive Decline in Nondemented Older Adults,” Neuroepidemiology, Vol. 21, No. 2, 2002, pp. 58-67. doi:10.1159/000048618

[9]   R. L. Doty, P. Shaman, S. L. Applebaum, R. Giberson, L. Siksorski and L. Rosenberg, “Smell Identification Ability: Changes With Age,” Science, Vol. 226, No. 4681, 1984, pp. 1441-1443. doi:10.1126/science.6505700

[10]   M. Wolfenberger and I. Schneiper, “Sniffin Sticks: A New System for Olfactory Assessement in Routine Clinical Practice,” HNO, Vol. 47, No. 7, 1999, pp. 629-636. doi:10.1007/s001060050436

[11]   K. A. Seiberling and D. B. Conley, “Aging and Olfactory and Taste Function,” Otolaryngologic Clinics of North America, Vol. 37, No. 6, 2004, pp. 1209-1228. doi:10.1016/j.otc.2004.06.006

[12]   M. Katotomichelakis, D. Balatsouras, G. Tripsianis, S. Davris, N. Maroudias, V. Danielides and C. Simopoulos, “The Effect of Smoking on the Olfactory Function,” Rhinology, Vol. 45, No. 4, 2007, pp. 273-280.

[13]   R. E. Frye, B. S. Schwartz and R. L. Doty, “Dose-Related Effects of Cigarette Smoking on Olfactory Function,” Journal of the American Medical Association, Vol. 263, No. 9, 1990, pp. 1233-1236. doi:10.1001/jama.1990.03440090067028

 
 
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