ABSTRACT A number of biological markers have been implicated in late life depression with inconsistent results. The present study examined the relationship between several serum based biomarkers and symptoms of depression in a sample of elderly women with AD or cognitively intact. Methods 171 females (58 with AD and 113 cognitively intact) were recruited from the Longitudinal Research Cohort of the Texas Alzheimer’s Research and Consortium (TARC). Stepwise regressions were conducted with GDS total and subscales and a panel of biomarkers (CRP, IL-10, IL-1α, TNF-α, ICAM-1, BDNF, and MIF). ApoE4 status was coded (carrier or non-carrier), and the results were analyzed by cognitive status (AD or controls). Results: None of the biomarkers significantly predicted total GDS score for AD cases, controls or sample as a whole. For the Controls, ICAM significantly predicted Dysphoria and level of Apathy. Among AD patients, MIF, ICAM, and CRP, were significantly associated with Apathy. MIF and ICAM were inversely associated with reported Apathy. CRP was positively associated with Apathy. CRP was also positively related to level of perceived Cognitive Impairment. Conclusions: The present study was one of the first to examine biomarkers related to depression symptoms in elderly women with AD and normal controls. For Controls ICAM alone predicted level of apathy. In the AD group, MIF, CRP, and ICAM were significantly associated with apathy. More research examining the relationship between biomarkers and depression is needed in older patients with and without cognitive impairment across genders.
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J. Hall, L. Johnson, H. Vo, R. Barber, A. Scott Winter and S. O’Bryant, "Biomarkers and Depressive Symptoms in Older Women with and without Cognitive Impairment," Journal of Behavioral and Brain Science, Vol. 2 No. 2, 2012, pp. 276-281. doi: 10.4236/jbbs.2012.22031.
 J. Wiltfang, P. Lewczuk, P. Riederer, E. Grunblatt, C. Hock, P. Scheltens and K. Blennow, “Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The Role of CSF and Blood Analysis in the Early and Differential Diagnosis of Dementia,” World Journal of Biological Psychiatry, Vol. 6, No. 2, 2006, pp. 69-84.
 S. E. Starkstein, P. Gustavo, E. Chemerinski and J. Kremer, “Syndromic Validity of Apathy in Alzheimer’s Disease,” American Journal Psychiatry, Vol. 158, 2001, pp. 872-877. doi:10.1176/appi.ajp.158.987.872
 H. T. Vo, B. D. Smith and S. Elmi, “Menstrual Endocrinology and Pathology: Premenstrual Syndrome: Caffeine, Physiology, and PMS,” In: B. Smith, Ed., Caffeine and Activation Theory: Effects on Health and Behavior, CRC Press, Boca Raton, 2007, pp. 12-22.
 J. Ryan, J., H. Burger, H., C. Szoeke, C., P. Lehert, P., M. L. Ancelin, V. W. Henderson and L. Dennerstein, “A Prospective Study of the Association Between Endogenous Hormones and Depression Symptoms in Postmenopausal Women,” Menopause, Vol. 16, No. 3, 2009, pp. 509-517.
 H. D’haenen, “Imaging the Serotonergic System in Depression,” European Achieves of Psychiatry and Clinical Neuroscience, Vol. 251, No. 2, 2001, pp. 76-80.
 J. L. Payne, “The Role of Estrogen in Mood Disorders in Women,” International Review of Psychiatry, Vol. 15, 2003, pp. 280-290. doi:10.1080/0954026031000136893
 J. T. Bromberger, H. M. Kraitz, Y. F. Chang, J. M. Cyranowski, C. Brown and K. S. Matthews, “Major Depression during and after the Menopausal Transition: Study of Women’s Health Across the Nation (SWAN),” Psychological Medicine, Vol. 41, No. 9, 2011, pp. 1879-1888.
 J. T. Bogousslavsky, “Emotions, Mood, and Behavior after Stroke,” Stroke, Vol. 34, No. 4, 2003, pp. 1046-1050.
 Y. Dowlati, N. Herrmann, W. Swardfager, H. Lui, L. Sham, E. K. Reim and K. L. Lanctot, “A Meta-Analysis of Cytokines in Major Depression,” Biological Psychiatry, Vol. 67, No. 5, 2010, pp. 446-457.
 M. A. Bremmer, A. T. Beekman, D. J. Deeg, B. W. Penninx, M. G. Dik, C. E. Hack and W. J. Hoogendiijk, “Inflammatory Markers in Late-Life Depression: Results from a Population-Based Study,” Journal of Affective Disorders, Vol. 106, No. 3, 2008, pp. 248-255.
 M. Berk, A. A. Wadee, R. H. Kuschke and A. O’Neill-Kerr, “Acute Phase Proteins in Major Depression,” Journal of Psychosomatic Research, Vol. 43, No. 5, 1997, pp. 529-534. doi:10.1016/S0022-3999(97)00139-6
 A. Sluzewska, J. Rybakowski, E. Bosmans, M. Sobieska, R. Berghmans, M. Maes and K. Wiktorowicz, “Indicators of Immune Activation in Major Depression,” Psychiatry Research, Vol. 64, No. 3, 1996, pp. 161-167.
 A. Reichenberg, R. Yirmiya, A. Schuld, T. Kraus, M. Haak, A. Morag and T. Pollmacher, “Cytokine-Associated Emotional and Cognitive Disturbances in Humans,” Archives of General Psychiatry, Vol. 58, No. 5, 2001, pp. 445-452. doi:10.1001/archpsyc.58.5.445
 H. Moshage, “Cytokines and the Hepatic Acute Phase Response,” Journal Pathology, Vol. 181, No. 3, 1997, pp. 257-266.
 E. M. Sternberg, G. P. Chrousos, R. L. Wilder and P. Gold, “The Stress Response and the Regulation of Inflammatory Disease,” Annals of Internal Medicine, Vol. 117, No. 10, 1992, pp. 854-866.
 K. S. Lee, J. H. Chung, K. H. Lee, M. J. Shin, B. H. Oh, S. H. Lee and C. H. Hong, “Simultaneous Measurement of 23 Plasma Cytokines in Late-Life Depression,” Neurological Science, Vol. 30, No. 5, 2009, pp. 435-438.
 C. L. Varea, J. E. Castro, H. Sakouhi-Ouertatani, T. Calandra, H. A. Lashuel and C. Sandi, “Macrophage Migration Inhibitory Factor is Critically Involved in Basal and Flouxetine-Stimulated Adult Hypocampal Cell Proliferation and in Anxiety, Depression, and Memory-Related Behaviors,” Molecular Psychiatry, Vol. 16, No. 5, 2010, pp. 543-577.
 K. Martinowich, K., H. Manji and B. Lu, “New Insights into BDNF Function in Depression and Anxiety,” Nature Neuroscience, Vol. 9, 2007, pp. 1089-1093.
 L. Pezawas, A. Meyer-Lindenberg, A. L. Goldman, B. A. Verchinski, G. Chen, B. S. Kolachana and D. R. Weinberger, “Evidence of Biologic Epistasis Between BDNF and SLC6A4 and Implications for Depression,” Molecular Psychiatry, Vol. 13, 2008, pp. 709-716.
 J. R. Hall, S. E. O’Bryant, L. Johnson and R. C. Barber, “Depression and Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease,” Neuroscience and Medicine, Vol. 2, No. 1, 2011, pp. 43-47.
 A. J. Thomas, I. N. Ferrier, R. N. Kalaria, S. A. Woodward, C. Ballard, A. Oakley, R. H. Perry and J. T. O’Brien, “Evaluation in Late-Life Depression of Intracellular Adhesion Molecule-1 Expression in the Dorsolateral Prefrontal Cortex,” American Journal of Psychiatry, Vol. 157, No. 10, 2000, pp. 1682-1684.
 A. J. Thomas, I. N. Ferrier, R. N. Kalaria, S. Davis and J. T. O’Brien, “Cell Adhesion Molecule Expression in the Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex in Major Depression in the Elderly,” British Journal of Psychiatry, Vol. 181, No. 1, 2002, pp. 129-134.
 T. Casoli, G. D. Stefano, M. Balietti, M. Solazzi, B. Giorgetti and P. Fattoreetti, “PeripheralInflammatory Biomarkers of Alzheimer’s Disease: The Role of Platelets,” Biogerontology, Vol. 11, No. 5, 2010, pp. 627-633.
 A. M. Kulminski, S. V. Ukraintseva, I. V. Kulminskaya, K. G. Arbeev, K. C. Land, L. Akushevich and A. L. Yashin, “Cumulative Deficits Better Characterize Susceptibility to Death in Elderly People than Phenotypic Frailty: Lessons from the Cardiovascular Health Study,” Journal of American Geriatric Society, Vol. 56, No. 5, 2008, pp. 898-903. doi:10.1111/j.1532-5415.2008.01656.x
 M. Edwards, C. Mauer, J. R. Hall, R. C. Barber and S. E. O’Bryant, “APOE Moderates Link between Affective Status and Cognition: A Project FRONTIER Study,” 119th Annual Meeting of the American Psychological Association, Washington DC, August 2011.
 J. R. Hall, S. E. O’Bryant, L. A. Johnson and R. Barber, “Depressive-Symptom Clusters and Neuropsychological Performance in Mild Alzheimer’s and Cognitively Intact Elderly,” Journal of Depression Research and Treatment, 2011, Article ID 396958.
 V. Vaccarino, B. D. Johnson, D. S. Sheps, S. E. Ras, S. F. Kelsey, V. Bittner and C. N. Merz, “Depression, Inflammation, and Incident Cardiovascular Disease in Women with Suspected Coronary Ischemia: The National Heart, Lung, and Blood Institute-Sponsored WISE Study,” Journal of the American College of Cardiology, Vol. 50, No. 21, 2007, pp. 2044-2050.
 J. R. Hall, H. Vo, L. Johnson, R. Barber, S. Winter and S. O’Bryant, “Biomarkers and Depressive Symptoms in Cognitively Intact and Alzheimer’s Disease Elderly Males,” Neuroscience and Medicine, 2011, in press.
 S. Waring, S. E. O'Bryant, J. S. Reisch, R. Diaz-Arrastia, J. Knebl and R. Doody, “The Texas Alzheimer’s Research Consortium Longitudinal Research Cohort: Study Design and Baseline Characteristics,” Texas Public Health Journal, Vol. 63, 2008, pp. 9-13.
 J. A. Yesavage, T. L. Brink, T. L. Rose, O. Lum, M. Huang, M. Adey and V. O. Leirer, “Development and Validation of a Geriatric Depression Screening Scale: A Preliminary Report,” Journal of Psychiatry Research, Vol. 17, No. 1, 1983, pp. 37-49.
 J. R. Hall and T. E. Davis, “Factor Structure of the Geriatric Depression Scale in Cognitive Impaired Older Adults,” Clinical Gerontology, Vol. 33, No. 1, 2010, pp. 39-48.
 S. E. O’Bryant, J. R. Hall, K. Cukrowicz, M. Edwards, L. A. Johnson, D. Lefforge and A. Dentino, “The Differential Impact of Depressive Symptom Clusters on Cognition in a Rural Multi-Ethnic Cohort: A Project FRONTIER Study,” International Journal of Geriatric Psychiatry, Vol. 26, No. 2, 2011, pp. 199-205. doi:10.1002/gps.2514
 B. W. Penninx, S. B. Kritchevsky, K. Yaffe, A. B. Newman, E. M. Simonsick, S. Rubin and M. Pahor, “Inflamatory Markers and Depressed Mood in Older Persons: Results from the Healthy, Aging and Body Composition Study,” Biological Psychiatry, Vol. 54, No. 5, 2003, pp. 566-572. doi:10.1016/S0006-3223(02)01811-5
 M. Piccinelli and G. Wilkinson, “Gender Differences in Depression,” British Journal of Psychiatry, Vol. 177, 2000, pp. 486-492. doi:10.1192/bjp.177.6.486