IJCM  Vol.3 No.3 , May 2012
Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature
Xanthoma of bone is a rare benign bone disorder. It radiologically presents as a lytic lesion, often with cortical expansion or disruption, mimics primary bone tumors and metastatic lesions. Histopathological study gives the definitive diagnosis. Xanthoma of bilateral tibia in a normolipidemic patient is rare and not yet reported in literature. Here with we present one such rare case, with review of literature.

Cite this paper
V. Kalyan Chakravarthi, E. Aruna, D. Naveen Chandra Rao and D. Ranga Rao, "Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature," International Journal of Clinical Medicine, Vol. 3 No. 3, 2012, pp. 234-237. doi: 10.4236/ijcm.2012.33047.
[1]   F. Bertoni, et al., “Xanthoma of Bone,” American Journal of Clinical Pathology, Vol. 90, No. 4, 1988, pp. 377-384.

[2]   P. D. Cruz Jr., C. East and P. R. Bergstresser, “Dermal, Subcutaneous, and Tendon Xanthomas: Diagnostic Markers for Specific Lipoprotein Disorders,” Journal of the American Academy of Dermatology, Vol. 19, No. 1, 1988, pp. 95-111. doi:10.1016/S0190-9622(88)70157-7

[3]   R. E. Fechner and S. E. Mills, “Tumors of the Bones and Joints,” In: R. E. Fechner and S. E. Mills, Eds., Armed Forces Institute of Pathology, Washington DC, 1993, pp. 145-171.

[4]   H. D. Dorfman and B. Czerniak, “Bone Tumors,” Mosby, St. Louis, 1998, pp. 492-558.

[5]   M. Franz, “Enzinger, Soft Tissue Tumours,” 3rd Edition, Mosby, St. Louis.

[6]   J. Kris, F. Edward and L. Kristy, “Weber, Xanthoma of Bone: A Report of Three Cases and Review of the Literature,” The Iowa Orthopaedic Journal, Vol. 28, 2008, pp. 58-64.

[7]   W. C. Hamilton, et al., “Osseous Xanthoma and multiple Hand Tumors as a Complication of Hyperlipidemia. Report of a Case,” Journal of Bone and Joint Surgery American Volume, Vol. 57, No. 4, 1975, pp. 551-553.

[8]   S. Inserra, et al., “Intraosseous Xanthoma Associated with Hyperlipoproteinemia. A Case Report,” Clinical Orthopaedics and Related Research, Vol. 187, 1984, pp. 218- 222.

[9]   K. Yokoyama, N. Shinohara and K. Wada, “Osseous Xanthomatosis and a Pathologic Fracture in a Patient with Hyperlipidemia. A Case Report,” Clinical Orthopaedics and Related Research, Vol. 236, 1988, pp. 307-310.

[10]   L. Algoed, et al., “A Large Intracranial Xanthoma in Familial Hypercholesterolemia,” Clinics in Neurology and Neurosurgery, Vol. 96, No. 1, 1994, pp. 79-82.

[11]   G. R. Bonhomme, et al., “Extensive Intracranial Xanthoma Associated with Type II Hyperlipidemia,” American Journal of Neuroradiology, Vol. 21, No. 2, 2000, pp. 353-355.

[12]   E. T. Elwood, et al., “Isolated Xanthoma of the Frontal Bone,” Journal of Craniofacial Surgery, Vol. 16, No. 3, 2005, pp. 391-394. doi:10.1097/01.scs.0000171963.93992.23

[13]   P. J. Emery and M. Gore, “An Extensive Solitary Xanthoma of the Temporal Bone, Associated with Hyperlipopro-teinaemia,” Journal of Laryngology and Otology, Vol. 96, No. 5, 1982, pp. 451-457. doi:10.1017/S0022215100092707

[14]   O. Friedman, et al., “Xanthoma of the Temporal Bone: A Unique Case of This Rare Condition,” Ear, Nose, and Throat Journal, Vol. 79, No. 6, 2000, pp. 433-436.

[15]   C. F. Huang, et al., “Xanthoma of Bone in a Normolipidemic Child: Report of One Case,” Acta Paediatrica Taiwanica, Vol. 41, No. 3, 2000, pp. 158-160.

[16]   R. K. Jackler and D. E. Brackmann, “Xanthoma of the Temporal Bone and Skull Base,” American Journal of Otology, Vol. 8, No. 2, 1987, pp. 111-115.

[17]   T. Kuroiwa and T. Ohta, A. Tsutsumi, “Xanthoma of the Temporal Bone: Case Report,” Neurosurgery, Vol. 46, No. 4, 2000, pp. 996-998.

[18]   M. Matoba, et al., “CT and MRI Findings of Xanthoma in the Orbitofrontal Region,” Radiation Medicine, Vol. 22, No. 2, 2004, pp. 116-119.

[19]   P. Kinberg, “Xanthoma of a Calcaneus,” Journal of Foot and Ankle Surgery, Vol. 37, No. 6, 1998, pp. 531-534. doi:10.1016/S1067-2516(98)80031-8

[20]   P. Sneider, “Xanthoma of the Calcaneus,” British Journal of Radiology, Vol. 36, No. 423, 1963, pp. 222-223. doi:10.1259/0007-1285-36-423-222

[21]   U. Yalcinkaya and F. Oztop, “Xanthoma of the Calcaneus Associated with Hyperlipoproteinemia,” Journal of the American Podiatric Medical Association, Vol. 95, No. 6, 2005, pp. 602-604.

[22]   T. Yamamoto, et al., “Multimodality Imaging Features of Primary Xanthoma of the Calcaneus,” Skeletal Radiology, Vol. 32, No. 6, 2003, pp. 367-370. doi:10.1007/s00256-003-0627-z

[23]   M. Marques Mateo, et al., “Primary Mandibular Bone Xanthoma. A Case Report,” International Journal of Oral and Maxillofacial Surgery, Vol. 33, No. 8, 2004, pp. 806-807.

[24]   P. J. Slootweg, J. G. N. Swart and N. Van Kaam, “Xantho-matous Lesion of the Mandible. Report of a Case,” International Journal of Oral and Maxillofacial Surgery, Vol. 22, No. 4, 1993, pp. 236-237. doi:10.1016/S0901-5027(05)80644-7

[25]   R. D. White and J. Makar Jr., “Xanthofibroma of the Mandible,” Journal of Oral and Maxillofacial Surgery, Vol. 44, No. 12, 1986, pp. 1010-1014. doi:10.1016/S0278-2391(86)80058-1

[26]   G. S. Huang, et al., “Xanthoma of the Sacrum,” Skeletal Radiology, Vol. 33, No. 11, 2004, pp. 674-678. doi:10.1007/s00256-004-0829-z

[27]   D. Dallari, et al., “Xanthoma of Bone: First Sign of Hyperlipidemia Type IIB: A Case Report,” Clinical Ortho- paedics and Related Research, Vol. 410, 2003, pp. 274- 277. doi:10.1097/01.blo.0000063790.32430.10

[28]   S. Boisgard, et al., “Intraosseous Xanthoma without Lipid Dis-orders. Case-Report and Literature Review,” Joint Bone Spine, Vol. 47, No. 1, 2000, pp. 71-74.

[29]   D. P. Ro-bertson, L. A. Langford and I. E. McCutcheon, “Primary Xanthoma of Thoracic Spine Presenting with Myelopathy,” Spine, Vol. 20, No. 17, 1995, pp. 1933-1937. doi:10.1097/00007632-199509000-00018

[30]   T. Torigoe, A. Terakado, Y. Suehara and H. Kurosawa, “Xanthoma of Bone Associated with Lipoprotein Lipase Deficiency,” Skeletal Radiology, Vol. 37, No. 12, 2008, pp. 1153-1156. doi:10.1007/s00256-008-0594-5

[31]   K. A. Muthusamy, M. Surg, K. Azmi, M. Rad, et al., “Bilateral Temporal Bone Xanthoma Case Report,” Journal of Neurosurg, Vol. 108, No. 2, 2008, pp. 361-364.

[32]   D. H. Henick and J. G. Feghali, “Bilateral Cholesterol Granuloma: An Unusual Presentation as an Intradural Mass,” Journal of Otolaryngology, Vol. 23, No. 1, 1994, pp. 15-18