Back
 SS  Vol.3 No.5 , May 2012
Leukemoid Reaction as a “Tumor Marker” in Breast Cancer
Abstract: Neutrophilic leukocytosis above 50 × 109/l exclude leukemia, defines a leukemoid reaction (LR). It is associated with several diseases. Although it simulates leukemia, most of the causes are benign. Tumor-related LR is more common. It is associated with ranulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. A 38-year-old woman, presented with advanced breast cancer and leukocytosis (79.9 × 103/uL) was found. After completion of MRM, the condition of leukocytosis subsided. Two months later, tumor local relapse was found and white blood cells (WBC) rose again. After completion of wide excision, the condition of leukocytosis subsided again. We think this case was associated with leukemoid reaction.
Cite this paper: C. Lin, J. Yu, J. Ou, Y. Lee and H. Wu, "Leukemoid Reaction as a “Tumor Marker” in Breast Cancer," Surgical Science, Vol. 3 No. 5, 2012, pp. 271-273. doi: 10.4236/ss.2012.35054.
References

[1]   H. S. Nimieri, S. N. Makoni, F. H. Madziwa and D. S. Nemiary, “Leukemoid Reaction Response to Chemotherapy and Radiotherapy in a Patient with Cervical Carcinoma,” Annals of Hematology, Vol. 82, No. 5, 2003, pp. 316-317.

[2]   V. Sakka, S. Tsiodras, E. J. Giamarellos-Bourboulis and H. Giamarellou, “An Update on the Etiology and Diagnostic Evaluation of a Leukemoid Reaction,” European Journal of Internal Medicine, Vol. 17, No. 6, 2006, pp. 394-398. doi:10.1016/j.ejim.2006.04.004

[3]   A. K. Ganti, A. Potti and S. Mehdi, “Uncommon Syndromes and Treatment Manifestations of Malignancy: Case 2. Metastatic Non-Small-Cell Lung Cancer Presenting with Leukocytosis,” Journal of Clinical Oncology, Vol. 21, No. 1, 2003, pp. 168-170.

[4]   I. Kasuga, S. Makino, H. Kiyokawa, H. Katoh, Y. Ebihara and K. Ohyashiki, “Tumor-Related Leukocytosis Is Linked with Poor Prognosis in Patients with Lung Carcinoma,” Cancer, Vol. 92, No. 9, 2001, pp. 2399-2405. doi:10.1002/1097-0142(20011101)92:9<2399::AID-CNCR1588>3.0.CO;2-W

[5]   M. Y. Lee and C. Rosse, “Depletion of Lymphocyte Subpopulations in Primary and Secondary Lymphoid Organs of Mice by a Transplanted Granulocytosis-Inducing Mammary Carcinoma,” Cancer Research, Vol. 42, No. 4, 1982, pp. 1255-1260.

[6]   M. P. MacManus, G. E. Elder, W. P. Abram and J. M. Bridges, “Effect of Recombinant Human Erythropoietin Anemia Caused by a Murine Mammary Carcinoma,” Experimental Hematology, Vol. 18, No. 7, 1990, pp. 848-852.

 
 
Top