PP  Vol.3 No.2 , April 2012
Pharmacokinetic Disposition of Streptomycin Sulfate in Japanese Eel (Anguilla japonica) after Oral and Intramuscular Administrations
Abstract: Pharmacokinetics and residue elimination of streptomycin sulfate (STR) are important in the determination of optimal dosage regimens and in establishing safe withdrawal periods in farmed fishes. The pharmacokinetics of STR was studied after a single dose (50 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to Japanese eel (Anguilla japonica) in freshwater at 25°C. Eight fish per sampling point were examined after treatment. Plasma and muscle were collected and analyzed by high-performance liquid chromatography (HPLC) method with 0.05 μg/ml detection limit. The data of pharmacokinetics conformed to the two-compartment open model for intramuscular and one-compartment open model for oral administrations. After intramuscular administration, the elimination half-life (t1/2β) was calculated to be 11.346 h, the maximum plasma concentration (Cmax) to be 29.524 μg/ml, the time to peak plasma streptomycin concentration (Tmax) to be 0.218 h, and the area under the plasma concentration-time curve (AUC) to be 90.206 μg/ml?h. Following p.o. administration, the corresponding estimates were 13.239 h, 0.346 μg/ml, 11.960 h, and 12.356 μg/ml?h. After intramuscular administration, a therapeutic concentration of the drug was maintained for 12 hours in the plasma, however, a therapeutic level could not be achieved after oral administration, and the results suggest that the drug can be used clinically by intramuscular administration against streptomycin susceptible systemic infections in Japanese eel.
Cite this paper: P. He, J. Shen, W. Yin, J. Yao, Y. Xu, X. Pan and G. Hao, "Pharmacokinetic Disposition of Streptomycin Sulfate in Japanese Eel (Anguilla japonica) after Oral and Intramuscular Administrations," Pharmacology & Pharmacy, Vol. 3 No. 2, 2012, pp. 195-200. doi: 10.4236/pp.2012.32026.

[1]   R. Krieger, “Handbook of Pesticide Toxicology, Principles, Part 1,” Academic Press, San Diego, 2001.

[2]   A. A. A. Hadi, I. A. Wasfi and A. K. Bsahir, “Pharmacokinetics of Streptomycin in Camels,” Journal of Veterinary Pharmacology and Therapeutics, Vol. 21, No. 6, 1998, pp. 494-496. doi:10.1046/j.1365-2885.1998.00171.x

[3]   C. Jayachandran, M. K. Singh, S. D. Singh and N. C. Banerjee, “Pharmacokinetics of Streptomycin with Particular Reference to Its Distribution in Plasma Milk and Uterine Fluid of Shebuffaloes,” Veterinary Research Communications, Vol. 71, 1987, pp. 353-358.

[4]   W. G. Venzke and C. R. Smith, “Streptomycin in Small Animal Medicine,” In: S. A. Waksrnan, Ed., Streptomycin: Nature and Practical Application, Willim & Wilkins Baltimore, Baltimore, 1949, p. 580.

[5]   J. D. Baggot, D. N. Lone, R. J. Rose and J. Raus, “Pharmacokinetics of Some Aminoglycoside Antibiotics in the Horse,” Journal of Veterinary Pharmacology and Therapeutics, Vol. 4, No. 4, 198l, pp. 277-284.

[6]   J. Y. Wang, W. J. Hu and Q. Y. Liu, “Studies on Pharmacokinetics of Streptomycin in Milk Goats,” Journal of Northwest Sci-Tech University of Agriculture and Forestry, Vol. 4, 1981, pp. 52-56.

[7]   E. A. Jackson and D. McLeod, “Pharmacokinetics and Dosing of Anti-Microbial Agents in Renal Impairment,” American Journal of Hospital Pharmacy, Vol. 31, 1974, pp. 137-146

[8]   K. Yamaoka, Y. Nakagawa and T. Uno, “Application of Akaike’s Information Criterion (AIC) in the Evaluation of Linear Pharmacokinetic Equations,” Journal of Pharmacokinetics and Biopharmaceutics, Vol. 6, No. 2, 1978, pp. 165-175

[9]   T. Guo, “Modern Pharmacokinetics,” China Science and Technology Press, Beijing, 2005, pp. 1-26.

[10]   D. A. Campbell, P. Pantazis and M. S. Kelly, “Impact and Residence Time of Oxytetracycline in the Sea Urchin, Psammechinus Miliaris, a Potential Aquaculture Species,” Aquacult, Vol. 202, 2001, pp. 73-87. doi:10.1016/S0044-8486(01)00600-7

[11]   Y. C. Zhou, H. P. Fan, B. C. Liao and Z. Z. Zeng, “An Anti-Bacterial Formula Study for Aeromonas hydrophila in Vitro,” Journal of Guangdong Ocean University, Vol. 30, No. 6, 2010, pp. 35-39.

[12]   L. G. Song, N. Guang, B. Yi, C. H. Yang, R. L. Wan, X. Y. Zhang, Q. Shi and D. Zhang, “Analysis for Antimicrobial Susceptibility of Streptococcus Suis Isolated from Sichuan Province,” Chinese Journal of Veterinary Drug, Vol. 39, No. 10, 2005, pp. 1-5.

[13]   A. Y. I. EI-Gendi, M. G. A. EI-Sayed, M. Atef and A. Z. Hussin, “Pharmacolinetic Interpretation of Some Antibiotics in Camels,” Archieves Internationales de Pharmacodynamic, Vol. 261, No. 2, 1983, pp. 186-195.

[14]   P. B. Hannond, “Dihydrostreptomycin Dose-Serum Level Relationships in Cattle,” Journal of the American Veterinary Medical Association, Vol. 122, No. 912, 1953, pp. 203-206.

[15]   R. H. Teske, L. D. Rolins and G. G. Carter, “Penicillin and Dihydrostreptomycin Serum Concentrations after Single and Repeated Doses to Feeder Steers,” Journal of the American Veterinary Medical Association, Vol. 160, No. 6, 1972, pp. 873-878.

[16]   H. D. Mercer, H. F. Righter, G. Gordon and A. B. Carter, “Serum Concentration of Penicillin and Dihydrostreptomycin after Their Parenteral Administration in Swine,” Journal of the American Veterinary Medical Association, Vol. 160, 1971, pp. 61-65.

[17]   W. G. Huber, “Streptomycin, Chloramphenicol, and Other Antibacterial Agents,” In: L. M. Jones, N. H. Boots, L. E. McDonald, Eds., Veterinary Pharmacology and Therapeutics, 4th Edition, Iowa State University Press, Ames, 1977, pp. 940-946.