ABSTRACT Injuries to muscle in the elite athlete are common and may be responsible for prolonged periods of loss of competitive activity. The implications for the athlete, his/her coach and team may be catastrophic if the injury occurs at a critical time in the athlete's diary. Imaging now plays a crucial role in diagnosis, prognostication and management of athletes with muscle injuries. This article discusses the methods available to clinicians and radiologists that are used to assess skeletal muscle injury. The spectrum of muscle injuries sustained in the elite athlete population is both discussed and illustrated.
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Gary Brown, S. , J. Harman, R. and L. Black, L. (2012) Adipose-derived stem cell therapy for severe muscle tears in working German shepherds: Two case reports. Stem Cell Discovery, 2, 41-44. doi: 10.4236/scd.2012.22007.
 Lee, J.C., et al. (2012) Imaging of muscle injuries. British Journal of Radiology, 2012.
 Quintero, A., Wright, V., Fu, F., et al. (2009) Stem cells for the treatment of skeletal muscle injury. Clinics in Sports Medicine, 28, 1-11.
 Lewis, D., Shelton, D., Piras, A., et al. (1997) Gracilis or semitendinosus myopathy in 18 dogs. Journal of the American Animal Hospital Association, 33, 177-188.
 Tidball, J. (2005) Inflammatory processes in muscle injury and repair. American Physiological Society American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, 288, 345-353.
 Hannafin, J.A., Pedowitz, R.A., Hidaka, C., et al. (1994) Pathophysiology and healing of musculoskeletal tissues, In: Griffin, L.Y. Ed., Orthopaedic Knowledge Update: Sports Medicine, American Academy of Orthopaedic, Rosemont, 17-33.
 Fukushima, K., Badlani, N., Usas, A., et al. (2001) The use of an antifibrosis agent to improve muscle recovery after laceration. The American Journal of Sports Medicine, 29, 394-402.
 Matziolis, G., Winkler, T., Schaser, K., Wiemann, M., et al. (2006) Autologous bone marrow-derived cells enhance muscle strength following skeletal muscle crush injury in rats. Tissue Engineering, 12, 361-367.
 Winkler, T., von Roth, P., Matziolis, G., et al. (2009) Doseresponse relationship of mesenchymal stem cell transplantation and functional regeneration after severe skeletal muscle injury in rats. Tissue Engineering, 15, 487-494.
 Ota, S., Uehara, K., Nozaki, M., et al. (2011) Intramuscular transplantation of muscle-derived stem cells accelerates skeletal muscle healing after contusion injury via enhancement of angiogenesis. The American Journal of Sports Medicine, 9, 1912-1922.
 Gimble, J., Bunnell, B., Chiu, E., et al. (2011) Concise Review: Adipose-derived stromal vascular fraction cells and stem cells: Let’s not get lost in translation. Stem Cells, 29, 749-754. doi:10.1002/stem.629
 Black, L., Gaynor, J., Gahring, D., et al. (2007) Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: A randomized, double-blinded, multicenter, controlled trial. Veterinary Therapeutics, 8, 272-284.
 Dahlgren, L.A. (2006) Use of adipose derived stem cells in tendon and ligament injuries. Proceedings of American College of Veterinary Surgeons—Veterinary Symposium Equine and Small Animal, 35, E5.
 Nixon, A., Dahlgren, L., Haupt, J., et al. (2008) Effect of adipose-derived nucleated cell fractions on tendon repair in a collagenase-induced tendinitis model. American Journal of Veterinary Research, 69, 1-10.
 Caplan, A. and Diego, C. (2011) The MSC: An injury drugstore. Cell Stem Cell, 9, 11-15.
 Kilroy, G., Foster, S., Wu, X., et al. (2007) Cytokine profile of human adipose-derived stem cells: Expression of angiogenic, hematopoietic, and pro-inflammatory factors. Journal of Cellular Physiology, 212, 702-709.
 Natsu, K., et al. (2004) Allogeneic bone marrow-derived mesenchymal stromal cells promote the regeneration of injured skeletal muscle without differentiation into myofibers. Tissue Engineering, 10, 1093-1112.
 Le Blanc, K. (2006) Mesenchymal stromal cells: Tissue repair and immune modulation. Cytotherapy, 8, 559-561.
 McIntosh, K., Zvonic, S., Garrett, S., et al. (2006) The immunogenicity of adipose derived cells: Temporal changes in vitro. Stem Cells, 24, 1246-1253.