JCDSA  Vol.2 No.1 , March 2012
Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid
Abstract: Natural vitamin E is suggested to have an antioxidant function. However, the synthetic form of vitamin E, DL-tocopherol, which has been widely used in topical ointments, may cause allergic contact dermatitis. Here, we report a case of allergic contact dermatitis with erythema multiforme-like eruption caused by a topical ointment. Patch testing indicated a positive allergic reaction to an anti-inflammatory ointment the patient had been using and its ingredient, DL-alpha-tocopheryl acetate (vitamin E). In addition, a positive reaction to glycyrrhetinic acid was observed. Both vitamin E and glycyrrhetinic acid are useful ingredients of topical applications. However, the possibility that both can cause contact dermatitis, albeit rarely, should be considered.
Cite this paper: K. Ohko, A. Ito and M. Ito, "Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 1, 2012, pp. 38-40. doi: 10.4236/jcdsa.2012.21009.

[1]   K. E. Burke, “Interaction of Vitamins C and E as Better Cosmeceuticals,” Dermatologic Therapy, Vol. 20, No. 5, 2007, pp. 314-321. doi:10.1111/j.1529-8019.2007.00145.x

[2]   R. H. Brodkin and J. Bleiberg, “Sensitivity to Topically Applied Vitamin E,” Archives of Dermatology, Vol. 92, No. 1, 1965, pp. 76-77. doi:10.1001/archderm.1965.01600130082016

[3]   J. Roed-Petersen and N. Hjorth, “Patch Test Sensitization from DL-alpha-tocopherol (Vitamin E),” Contact Dermatitis, Vol. 1, No. 6, 1975, p. 391.

[4]   H. Saperstein, M. Rapaport and R. L. Rietschel, “Topical Vitamin E as a Cause of Erythema Multiforme-Like Eruption,” Archives of Dermatology, Vol. 120, No. 7, 1984, pp. 906-908. doi:10.1001/archderm.1984.01650430092016

[5]   A. C. de Groot, P. J. Berretty, C. J. van Ginkel, C. W. den Hengst, J. van Ulsen and J. W. Weyland, “Allergic Contact Dermatitis from Tocopheryl Acetate in Cosmetic Creams,” Contact Dermatitis, Vol. 25, No. 5, 1991, pp. 302-304. doi:10.1111/j.1600-0536.1991.tb01878.x

[6]   B. Garcia-Bravo and P. Mozo, “Generalized Contact Dermatitis from Vitamin E,” Contact Dermatitis, Vol. 26, No. 4, 1992, p. 280. doi:10.1111/j.1600-0536.1992.tb00258.x

[7]   D. Manzano, A. Aguirre, J. Gardeazabal, X. Eizaguirre and J. L. Diaz Perez, “Allergic Contact Dermatitis from Tocopheryl Acetate (Vitamin E) and Retinol Palmitate (Vitamin A) in a Moisturizing Cream,” Contact Dermatitis, Vol. 31, No. 5, 1994, p. 324. doi:/10.1111/j.1600-0536.1994.tb02030.x

[8]   T. Matsumura, T. Nakada and M. Iijima, “Widespread Contact Dermatitis from Tocopherol Acetate,” Contact Dermatitis, Vol. 51, No. 4, 2004, pp. 211-212. doi:10.1111/j.0105-1873.2004.0424b.x

[9]   A. Ramirez Santos, V. Fernandez-Redondo, L. Perez Perez, J. Concheiro Cao and J. Toribio, “Contact Allergy from Vitamins in Cosmetic Products,” Dermatitis, Vol. 19, No. 3, 2008, pp. 154-156.

[10]   R. Rietshel and J. Fowler, “Fisher’s Contact Dermatitis 6,” BC Decker Inc., Hamilton, 2008.

[11]   S. Tanaka, T. Otsuki, Y. Matsumoto, R. Hayakawa and M. Sugiura, “Allergic Contact Dermatitis from Enoxolone,” Contact Dermatitis, Vol. 44, No. 3, 2001, p. 192. doi:10.1034/j.1600-0536.2001.440308-13.x

[12]   J. C. Fernandez, P. Gamboa, I. Jauregui, G. Gonzalez and I. Antepara, “Concomitant Sensitization to Enoxolone and Mafenide in a Topical Medicament,” Contact Dermatitis, Vol. 27, No. 4, 1992, p. 262. doi:10.1111/j.1600-0536.1992.tb03263.x

[13]   N. Oiso, T. Ota, E. Yoshinaga, H. Endo, S. Kawara and A. Kawada, “Allergic Contact Dermatitis Mimicking Atopic Dermatitis Due to Enoxolone in a Topical Medicament,” Contact Dermatitis, Vol. 54, No. 6, 2006, p. 351. doi:10.1111/j.0105-1873.2006.0645i.x