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 CM  Vol.3 No.1 , March 2012
Evidence for the Safe Use of the Extract from the Brazilian Arnica, Solidago chilensis Meyen, in Primary Health Care
Abstract: In Brazil, the National Policy on Medicinal Plants has stimulated the use of plants in primary health care, validating the traditional medicine and pointing to the lack of a consistent set of evidence that supports their uses and indications by ethnobotany and ethnopharmacology. This paper aims to make a systematic review of the scientific literature to gather evidence on indications and safety of use of extracts of Solidago chilensis. The bibliographic research was carried out using terms derivate from the title, and all the published papers were downloaded, covering at least the last five years, and it was focused on preclinical and clinical studies with extracts of S. chilensis in the databases of Web of Science, BIREME, SciELO, PubMed, Scirus and Highwire. Phytochemical analysis carried out on many studies showed that among the chemical constituents of S. chilensis are sesqui- and diterpenes, flavonoids and other substances, and the diterpene solidagenone was identified as a marker of the extract that has demonstrated gastroprotective activity in different experimental models of ulcer induced in animals without signs of toxicity at doses above 600 mg/kg. Another studies show that the anti-inflammatory effect in rats has been given by inhibiting the exudation of leukocytes, especially neutrophils, as well as through inhibition of myeloperoxidase, adenosine deaminase, and tumor necrosis factor-α (TNF-α), decreased induction of nitric oxide synthesis and levels of interleukin-1β. Studies show that solidagenone at a concentration of 100 mg/kg showed activity similar to lansoprazole (20 mg/kg), the effect occurs without changes in the gastric mucosa or on acid secretion. The aqueous and alcoholic extracts showed anti-inflammatory activity and may act in a satisfactory way in cases involving the inflammatory response, such as injuries due to trauma, repetitive stress, pain, and healing. The inhibition of anti-inflammatory response is on the base of all these described effects. In spite of the fact that S. chilensis has been used since ancient times in Brazilian traditional medicine, and the existence of preclinical pharmacological end toxicological evidence for its efficacy as an inhibitor of anti-inflammatory response, we could find only a single clinical trial study carried out in treating lumbago. In this lack of clinical pharmacology and toxicology evidence for its uses, its safety and therapeutic indications are guaranteed, up to this moment, by traditional knowledge.
Cite this paper: A. Mercandeli, G. Bessa, S. Ronchi, T. Segato and A. Silva, "Evidence for the Safe Use of the Extract from the Brazilian Arnica, Solidago chilensis Meyen, in Primary Health Care," Chinese Medicine, Vol. 3 No. 1, 2012, pp. 4-8. doi: 10.4236/cm.2012.31002.
References

[1]   E. L. Ratera and M. O. Ratera, “Plantas de la Flora Argentina Empleadas en Medicina Popular,” Hemisferio Sur, Buenos Aires, 1980.

[2]   J. R. Alonso, “Tratado de Fitomedicina Bases Clínicas y Farmacológicas,” ISIS Editiones, Buenos Aires, 2004.

[3]   M. C. T. Duarte and G. M. Figueira, “Anti-Candida Activity of Essential Oils and Extracts from Native and Exotic Medicinal Plants Used in Brazil,” The Haworth Press Inc., 2004.

[4]   Política Nacional de Plantas Medicinais e Fitoterápicos. http://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf

[5]   Programa Nacional de Plantas Medicinais. http://portal.saude.gov.br/portal/arquivos/pdf/politica_plantas_medicinais_fitoterapia.pdf

[6]   Diário Official da Uni?o, “Agência Nacional de Vigilancia Sanitária,” Disp?e Sobre Registro de Fitoterápicos, 2010, pp. 85-87.

[7]   R. F. Vieira, “Conservation of Medicinal and Aromatic Plants in Brazil,” In: J. J. Alexandria, Ed., Perspectives on New Crops and New Uses, ASHS Press, 1999, pp. 152-159.

[8]   S. Miguel, “A Arnica Desvendada,” Jornal da USP, Vol. 22, 2007, pp. 22-26.

[9]   P. Weyerstahl, H. Marschall, C. Christiansen, D. Kalemba and J. Góra, “Constituents of the Essential Oil of Solidago canadensis (“Goldenrod”) from Poland—A Correction,” Planta Medica, Vol. 59, No. 3, 1993, pp. 281-282. doi:10.1055/s-2006-959673

[10]   R. A. D. Silva, “Arnica Silvestre,” Graphic Industry, S?o Paulo, 1929.

[11]   A. S. C. Borges, “Efeito do Extrato de Solidago micro-glossa DC Sobre a Dissolu??o de Coágulos e a Hid- rólise de Nμ-Benzoil-D, L-Arginina-Para-Nitroanilida,” M.Sc. Dissertation, Federal University of Uberlandia, Uber- landia, 2001.

[12]   V. Maioli-Azevedo and V. S. Fonseca-Kruel, “Plantas Medicinais e Ritualísticas Vendidas em Feiras Livres No Município do Rio de Janeiro, RJ, Brasil, Estudo de Caso nas zonas Norte e Sul,” Acta Botanica Brasilica, Vol. 21, No. 2, 2007, pp. 263-275. doi:10.1590/S0102-33062007000200002

[13]   G. Guarim-Neto and R. G. Morais, “Recursos Medicinais de Espécies do Cerrado de Mato Grosso, um Estudo Bibliográfico,” Acta Botanica Brasilica, Vol. 17, 2003, pp. 561-584.

[14]   C. E. T. Parente and M. M. T. Rosa, “Plantas Comercializadas Como Medicinais no Município de Barra do Piraí, RJ,” Rodriguésia, Vol. 52, 2001, pp. 47-59.

[15]   A. G. Christo, R. R. Guedes-Bruni, et al., “Uso de Recursos Vegetais em Comunidades Limítrofes à Reserva Biológica de Po?o das Antas, Silva Jardim, RJ, Estudo de caso na Gleba Aldeia Velha,” Rodriguesia, Vol. 57, 2006, pp. 519-542.

[16]   P. Apáti, P. J. Houghton, G. Kite, G. B. Steventon and A. Kéry, “In Vitro Effect of Flavonoids from Solidago canadensis Extract on Glutathione Transferase,” Journal of Pharmacy and Pharmacology, Vol. 58, No. 2, 2006, pp. 251-256. doi:10.1211/jpp.58.2.0013

[17]   A. H. Ladio and M. Lozada, “Edible Wild Plant Use in a Mapuche Community of Northwestern Patagonia,” Human Ecology, Vol. 28, No. 1, 2000, pp. 53-71. doi:10.1023/A:1007027705077

[18]   D. Estomba, A. Ladio and M. Lozada, “Medicinal Wild Plant Knowledge and Gathering Patterns in a Mapuche Community from North-Western Patagonia,” Journal of Ethnopharmacology, Vol. 103, No. 1, 2006, pp. 109-119. doi:10.1016/j.jep.2005.07.015

[19]   R. H?nsel, K. Keller, H. Rimpler and G. Scheider, “Hagers Handbuch der Pharmazeutischen Praxis,” Springer, Berlin, 1994.

[20]   M. Blumenthal, W. R. Busse and A. Goldberg, “The Complete German Commission e Monographs,” American Botanical Council, Austin and Integrative Medicine Communications, Boston, 1998.

[21]   M. Soares, T. C. B. Tomassini, P. H. Leda, J. F. O. Costa and R. R. Santos, “Solidago chilensis Meyen—Solidagenona Como Agente Imunomodulador,” XXVI Congresso Latino Americano de Química, Salvador, 2004.

[22]   M. P. Corrêa, “Dicionário das Plantas úteis do Brasil e das Exóticas Cultivadas,” Ministério da Agricultura, Brasília, 1984.

[23]   R. A. Moreira, et al., “Interest of Pharmaceutical Involved in Dispensing, for Medicinal Plants and Herbal Medicine,” Infarma, Vol. 3-4, 2001, pp. 72-75.

[24]   E. E. Sanguinetti, “Plantas que Curam,” Rigel, Porto Alegre, 1989.

[25]   H. Lorenzi and F. J. A. Matos, “Plantas Medicinais No Brasil, Nativas e Exóticas,” Instituto Plantarum de Estudos da Flora, Sao Paulo, 2002.

[26]   A. F. Morel, G. O. Dias, C. Porto, et al., “Antimicrobial Activity of Extractives of Solidago microglossa,” Fitoterapia, Vol. 77, No. 6, 2006, pp. 453-455. doi:10.1016/j.fitote.2006.05.006

[27]   G. Schmeda-Hirschmann, J. Rodriguez and L. Astudillo, “Gastroprotective Activity of the Diterpene Solidagenone and Its Derivates on Experimentally Induced Gastric Lesions in Mice,” Journal of Ethnopharmacology, Vol. 81, No. 1, 2002, pp. 111-115. doi:10.1016/S0378-8741(02)00054-5

[28]   D. A. Lewis and P. J. Hanson, “Antiulcer Drugs of Plant Origin,” Progress in Medicinal Chemistry, Vol. 28, 1991, pp. 210-229. doi:10.1016/S0079-6468(08)70365-5

[29]   C. A. Hiruma-Lima, R. C. Spadari-Bratfisch, D. M. Grassi-Kassisse and A. R. Brito, “Antiulcerogenic Mechanisms of Dehydro-Crotonin, a Diterpene Lactone Obtained from Croton cajucara,” Planta Medica, Vol. 65, No. 4, 1999, pp. 325-330. doi:10.1055/s-1999-13995

[30]   I. Razmilic and G. Schmeda-Hirschmann, “Activity of Solidagenone and Their Semisynthetic Derivatives on the Glucocorticoid-Mediated Signal Transduction,” Planta Medica, Vol. 66, 2000, pp. 86-88.

[31]   S. Goulart, M. I. Moritz, K. L. Lang, R. Liz, E. P. Schenkel and T. S. Fr?de, “Anti-Inflammatory Evaluation of Solidago chilensis Meyen in a Murine Model of Pleurisy,” Journal of Ethnopharmacology, Vol. 113, No. 2, 2007, pp. 346-353. doi:10.1016/j.jep.2007.07.003

[32]   A. G. Silva, C. P. G. Sousa, et al., “Evaluation of an Extract of Brazilian Arnica (Solidago chilensis Meyen, Asteraceae) in Treating Lumbago,” Phytotherapy Research, Vol. 24, 2010, pp. 283-287.

[33]   R. Liz, S. V. G. Vigil, et al., “The Anti-Inflammatory Modulatory Role of Solidago chilensis Meyen in the Murine Model of the Air Pouch,” Journal of Pharmeuticals and Pharmacology, Vol. 60, No. 4, 2008, pp. 515- 521. doi:10.1211/jpp.60.4.0015

[34]   L. M. B. Torres, “Estudo Químico da Espécie Solidago microglossa DC,” Ph.D. Thesis, S?o Paulo University, S?o Paulo, 1985.

[35]   W. Ma and R. Quirion, “Does COX2-Dependent PGE2 Play a Role in Neuropathic Pain?” Neuroscience Letters, Vol. 437, No. 3, 2008, pp. 165-169. doi:10.1016/j.neulet.2008.02.072

[36]   K. Ren and R. Torres, “Role of Interleukin-1β during Pain and Inflammation,” Brain Research Reviews, Vol. 60, No. 1, 2009, pp. 57-64. doi:10.1016/j.brainresrev.2008.12.020

[37]   I. H. Hall, C. O. Starnes, K. H. Lee and T. G. Waddell, “Mode of Action of Sesquiterpene Lactones as Anti-Infla- mmatory Agents,” Journal of Pharmaceutical Sciences, Vol. 69, No. 5, 1980, pp. 537-543. doi:10.1002/jps.2600690516

[38]   S. Omoigui, “The Biochemical Origin of Pain, the Origin of All Pain Is Inflammation and the Inflammatory Response. Inflammatory Profile of Pain Syndromes,” Medical Hypotheses, Vol. 69, No. 6, 2007, pp. 1169-1178. doi:10.1016/j.mehy.2007.06.033

[39]   M. D. Santos, L. Gobbo-Neto, L. Albarella, G. Souza and N. P. Lopes, “Analgesic Activity of Di-Caffeoylquinic Acids from Roots of Lychnophora ericoides (Arnica da Serra),” Journal of Ethnopharmacology, Vol. 96, 2005, pp. 545-549.

[40]   A. Shai and H. I. Maibach, “Diagnosis and Therapy. The Practical Approach,” Marion Philipp, Germany, 2005.

 
 
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