SS  Vol.3 No.3 , March 2012
Liver Metastases from Gynecological Cancers: Time to Resection?
Abstract
Aim: To perform an update of liver resection as treatment of liver metastases of gynecological cancers, as well as an update on these metastases. Bibliographical search: PubMed Search 1990-2011 in English language. Authors reviewed only relevant articles. Results: No more than 20 relevant articles have been published on this topic, including case reports. We performed a classical review of the information published in the literature. Conclusions: Liver Metastases from Gynecological cancers, not peritoneal implants in the liver, usually appear in patients with disseminated disease, so it is uncommon to perform a liver resection. In some patients with limited extrahepatic disease or only liver disease, liver resection is a safe alternative and improves the oncological results. We try to emphasize which patients may benefit from liver resection and the importance of tailoring medical decisions.

Cite this paper
J. Ramia, R. Plaza, J. Quiñones, P. Veguillas, F. Adel and J. García-Parreño, "Liver Metastases from Gynecological Cancers: Time to Resection?," Surgical Science, Vol. 3 No. 3, 2012, pp. 120-125. doi: 10.4236/ss.2012.33024.
References

[1]   O. Kollmar, M. R. Moussavian, S. Richter, M. Bolli and M. K. Schilling, “Surgery of Liver Metastasis in Gynecological Cancer—Indication and Results,” Onkologie, Vol. 31, No. 7, 2008, pp. 375-379.

[2]   G. Abood, M. Bowen, R. Potkul, G. Aranh and M. Shoup, “Hepatic Resection for Recurrent Metastasic Ovarian Cancer,” American Journal of Surgery, Vol. 195, No. 3, 2008, pp. 370-373. doi:10.1016/j.amjsurg.2007.12.012

[3]   S. A. Earle, E. A. Perez, J. C. Gutierrez, D. Sleeman, A. S. Livingstone, D. Franceschi, et al., “Hepatectomy Enables Prolonged Survival in Select Patients with Isolated Noncolorectal Liver Metastasis,” Journal of the American College of Surgeons, Vol. 203, No. 4, 2006, pp. 436-446. doi:10.1016/j.jamcollsurg.2006.06.031

[4]   S. S. Yoon, W. R. Jarnagin, Y. Fong, R. P. DeMatteo, R. R. Barakat, L. H. Blumgart and D. S. Chi, “Resection of Recurrent Ovarian or Fallopian Tuve Carcinoma Involving the Liver,” Gynecologic Oncology, Vol. 91, No. 2, 2003, pp. 383-388. doi:10.1016/j.ygyno.2003.07.005

[5]   D. S. Chi, Y. Fong, E. S. Venkatraman and R. R. Barakat, “Hepatic Resection for Metastasic Gynecologic Carcinomas,” Gynecologic Oncology, Vol. 66, No. 1, 1997, pp. 45-51. doi:10.1006/gyno.1997.4727

[6]   S. K. Reddy, A. S. Barbas, C. Marroquin, M. A. Morse, P. C. Kuo and B. M. Clary, “Resection of Non Colorectal Nonneuroendorine Liver Metastases: A Comparative Analysis,” Journal of the American College of Surgeons, Vol. 204, No. 3, 2007, pp. 372-382. doi:10.1016/j.jamcollsurg.2006.12.019

[7]   T. R. O’Rourke, P. Tekkis, S. Yeung, J. Fawcett, S. Lynch, R. Strong, et al., “Long-Term Results of Liver Resection for Non-Colorectal, Non-Neuroendocrine Metastases,” Annals of Surgical Oncology, Vol. 15, No. 1, 2008, pp. 207-218. doi:10.1245/s10434-007-9649-4

[8]   R. Adam, L. Chiche, T. Aloia, D. Elias, R. Salmon, M. Rivoire, et al., “Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases,” Annals of Surgery, Vol. 244, 2006, pp. 524-535.

[9]   M. Schmelzle, C. F. Eisenberger, S. Schulte, H. Matthaei, M. Krausch and W. T. Knoefel, “Non-Colorectal, Non-Neuroendocrine, and Non-Sarcoma Metastases of the Liver: Resection as a Promising Tool in the Palliative Management,” Langenbeck’s Archives of Surgery, Vol. 395, No. 3, 2010, pp. 227-234. doi:10.1007/s00423-009-0580-y

[10]   N. Kawagishi, Y. Shirihata, K. Ishida, K. Satoh, Y. Enomoto, Y. Akamatsu, et al., “Hepatic Resection of Giant Metastatic Tumor from Clear Carcinoma of the Ovary,” Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 12, No. 2, 2005, pp. 155-158. doi:10.1007/s00534-004-0957-9

[11]   M. C. Lim, S. Kang, K. S. Lee, S. S. Han, S. J. Park, S. S. Seo and S. Y. Park, “The Clinical Significance of Hepatic Parenchymal Metastasis in Patients with Primary Epitelial Ovarian Cancer,” Gynecologic Oncology, Vol. 112, No. 1, 2009, pp. 28-34. doi:10.1016/j.ygyno.2008.09.046

[12]   S. Tangjitgamol, C. F. Levenback, U. Beller and J. J. Kavanagh, “Role of Surgical Resection for Lung, Liver, and Central Nervous System Metastases in Patients with Gynecological Cancer: A Literature Review,” International Journal of Gynecological Cancer, Vol. 14, No. 3, 2004, pp. 399-422. doi:10.1111/j.1048-891x.2004.14326.x

[13]   D. R. Carpizo and M. D’Angelica, “Liver Resection for Metastasic Colorectal Cancer in the Presence of Extrahepatic Disease,” Annals of Surgical Oncology, Vol. 16, No. 9, 2009, pp. 2411-2421. doi:10.1245/s10434-009-0493-6

[14]   S. Pekmezci, K. Saribeyoglu, E. Aytac, M. Arvas, F. Demirkiran and M. Ozguroglu, “Surgery for Isolated Liver Metastasis of Ovarian Cancer,” Asian Journal of Surgery, Vol. 33, No. 2, 2010, pp. 83-88. doi:10.1016/S1015-9584(10)60014-0

[15]   G. Ercolani, G. L. Grazi, M. Ravaioli, G. Ramacciato, M. Cescon, et al., “The Role of liver Resections for Noncolorectal Nonneuroendocrine Metastases: Experience with 142 Observed Cases,” Annals of Surgical Oncology, Vol. 12, No. 6, 2005, pp. 1-8. doi:10.1245/ASO.2005.06.034

[16]   D. S. Chi, S. M. Temkin, N. R. Abu-Rustum, P. Sabattini, W. Jarnagin and L. H. Blumgart, “Major Hepatectomy at Interval Debulking for Satge IV Ovarian Carcinoma: A Case Report,” Gynecologic Oncology, Vol. 87, No. 1, 2002, pp. 138-142. doi:10.1006/gyno.2002.6717

[17]   V. Loizzi, C. Rossi, G. Cormio, A. Cazzolla, D. Altomare and L. Selvaggi, “Clinical Features of Hepatic Metastasis in Patients with Ovarian Cancer,” International Journal of Gynecological Cancer, Vol. 15, No. 1, 2005, pp. 26-31. doi:10.1111/j.1048-891x.2005.14406.x

[18]   National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/pdf/ovarian.pdf

[19]   National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf

[20]   E. Vibert and E. Castaing, “Surgical Treatment of Liver Metastases of Gynecological Cancer: Local Treatment of a Systemic Disease,” Onkologie, Vol. 31, No. 8-9, 2008, pp. 425-426. doi:10.1159/000143274

[21]   M. A. Merideth, W. A. Cliby, G. L. Keeney, T. G. lesnick, D. M. Nagorney and K. C. Podratz, “Hepatic Resection for Metachronous Metastases from Ovarian Carcinoma,” Gynecologic Oncology, Vol. 89, No. 1, 2003, pp. 16-21. doi:10.1016/S0090-8258(03)00004-0

[22]   G. E. Chalkiadakis, K. G. Lasithiotakis, I. Petrakis, C. Kourousis and V. Georgoulias, “Major Hepatectomy and Right Hemicolectomy at Thetime of Primary Cytoreductive Surgery for Advanced Ovarian Cancer: Report of a Case,” International Journal of Gynecological Cancer, Vol. 15, No. 6, 2005, pp. 1115-1119. doi:10.1111/j.1525-1438.2005.00169.x

[23]   R. Mateo, G. Singh, N. Jabbour, S. Palmer, Y. Genyk and L. Roman, “Optimal Cytoreduction after Combined Resection and Radiofrequency Ablation of Hepatic Metastases from Recurrent Malignant Ovarian Tumors,” Gynecologic Oncology, Vol. 97, No. 1, 2005, pp. 266-270. doi:10.1016/j.ygyno.2004.12.038

[24]   W. E. Winter, L. Maxwell, C. Tian, M. J. Sundborg, G. S. Rose, P. G. Rose, et al., “Tumor Residual after Surgical Cytoreduction in Prediction of Clinical Outcome in Stage IV Epithelial Ovarian Cancer: A Gynecological Oncology Group Study,” Journal of Clinical Oncology, Vol. 26, No. 1, 2008, pp. 83-89. doi:10.1200/JCO.2007.13.1953

[25]   R. E. Bristow, F. J. Montz, L. D. Lagasse, R. S. Leuchter and B. Y. Karlan, “Survival Impact of Cytoreduction in Stage IV Epithelian Ovarian Cancer,” Gynecologic Oncology, Vol. 72, No. 3, 1999, pp. 278-287. doi:10.1006/gyno.1998.5145

[26]   P. G. Rose, M. S. Piver, Y. Tsukada and T. S. Lau, “Metastastic Patterns in Histologic Variants of Ovarian Cancer. An Autopsy Study,” Cancer, Vol. 64, No. 7, 1989, pp. 1508-1513. doi:10.1002/1097-0142(19891001)64:7<1508::AID-CNCR2820640725>3.0.CO;2-V

[27]   I. A. Jacobs, C. K. Chang and G. Salt, “Hepatic Radiofrequency Ablation of Metastatic Ovarian Granulosa Cell Tumors,” American Journal of Surgery, Vol. 69, No. 5, 2003, pp. 416-418.

[28]   O. Akin, E. Sala, C. S. Moskowitz, N. Ishill, R. A. Soslow, D. S. Chi and H. Hricak, “Perihepatic Metastases from Ovarian Cancer: Sensitivity and Specificity of CT for the Detection of Metastases with and Those without liver Parenchymal Invasion,” Radiology, Vol. 248, 2008, pp. 511-517. doi:10.1148/radiol.2482070371

[29]   G. E. Kim, S. W. Lee and C. O. Suh, “Hepatic Metastases from Carcinoma of the Uterine Cervix,” Gynecologic Oncology, Vol. 70, No. 1, 1998, pp. 56-60. doi:10.1006/gyno.1998.5037

[30]   Q. Fan, H. Huang, L. Lian and J. Lang, “Characteristics, Diagnosis, and Treatment of Hepatic Metastasis Pure Inmature Ovarian Teratoma,” Chinese Medical Journal, Vol. 114, No. 5, 2001, pp. 506-509.

[31]   T. K. Madhuri, S. Butler-Manuel, N. Karanjia and A. Tailor, “Liver Resection for Metastases Arising from Recurrent Granulosa Cell Tumor of the Ovary—A Case Series,” European Journal of Gynaecological Oncology, Vol. 31, No. 3, 2010, pp. 342-344

[32]   T. Pawlik, T. Vauthey, E. Abdalla, R. Pollock, L. M. Ellis and S. A. Curley, “Results of a Single Center Experience with Resection and Ablation for Sarcoma Metastatic to the Liver,” Archives of Surgery, Vol. 141, No. 6, 2006, pp. 537-544.

 
 
Top