JBiSE  Vol.3 No.5 , May 2010
In vitro evaluation of a new resilient, hard-carbon, thin-film coating as a bearing material for ventricular assist devices ——In Vitro Bearing Evaluation of BioMedFlex
ABSTRACT
Our aim was to evaluate the potential use of BioMedFlex® (BMF), a new resilient, hard-carbon, thin- film coating, as a blood journal bearing material in Cleveland Heart’s continuous-flow left and right ven- tricular assist devices (VADs). BMF is not classified as a diamond-like carbon (DLC) and differs from other thin-film carbon coatings by its high flexural strength, radiopacity, and wear resistance. A 2- to 4-μm-thick BMF adhesion layer was deposited on the VAD journal bearing surfaces. A commercial DLC coating used in other clinical blood pump applications was used as a control. Durability and reliability of the BMF coating was verified in severe pump start/stop testing using 20 BMF-coated journal bearing pairs. The BMF-coated surfaces showed no coating failures, whereas 57% of the DLC bearing pairs developed scratches through the carbon coating, documenting that BMF can provide a durable coating in our blood journal bearing application. In conclusion, BMF has shown qualities that support its significant advantages as an alternative journal bea- ring material in Cleveland Heart pumps. Our plan includes biocompatibility testing with ongoing animal studies, endurance testing with submerged pumps running in saline, and assessment of batch coating processing capability.

Cite this paper
nullMielke, N. , Massiello, A. , Horvath, D. , Benefit, S. , Burgess, D. , Golding, L. and Fukamachi, K. (2010) In vitro evaluation of a new resilient, hard-carbon, thin-film coating as a bearing material for ventricular assist devices ——In Vitro Bearing Evaluation of BioMedFlex. Journal of Biomedical Science and Engineering, 3, 525-528. doi: 10.4236/jbise.2010.35073.
References
[1]   Fukamachi, K., Horvath, D.J., Massiello, A.L., Ootaki, Y., Kamohara, K., Akiyama, M., Zahr, F., Kopcak, M.W., Dessoffy, R., Chen, J.F., Benefit, S. and Golding, L.R. (2005) Development of a small implantable right ventricular assist device. American Society for Artificial Internal Organs Journal, 51(6), 730-735.

[2]   Ootaki, Y., Kamohara, K., Akiyama, M., Zahr, F., Kopcak, M.W., Dessoffy, R., Massiello, A.L., Horvath, D.J., Chen, J.F., Benefit, S., Golding, L.R. and Fukamachi, K. (2005) Initial in vivo evaluation of the DexAide right ventricular assist device. American Society for Artificial Internal Organs Journal, 51(6), 739-742.

[3]   BioMedFlex, LLC, Accessed November 27, 2009. http:// www.BioMedFlex.com

[4]   Yamazaki, K., Litwak, P., Tagusari, O., Mori, T., Kono, K., Kameneva, M., Watach, M., Gordon, L., Miyagishima, M., Tomioka, J., Umezu, M., Outa, E., Antaki, J.F., Kormos, R.L., Koyanagi, H. and Griffith, B.P. (1998) An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal system). Artificial Organs, 22(6), 466-474.

[5]   Malanoski, S.B., Belawski, H., Horvath, D.J., Smith, W.A. and Golding, L.R. (1998) Stable blood lubricated hydrodynamic journal bearing with magnetic loading. American Society for Artificial Internal Organs Journal, 44(5), M737-M740.

[6]   Takaseya, T., Fumoto, H., Shiose, A., Arakawa, Y., Rao, S., Horvath, D.J., Massiello, A.L., Mielke, N.A., Chen, J.F., Zhou, Q., Dessoffy, R., Kramer, L., Benefit, S., Golding, L.R. and Fukamachi, K. (2009) In vivo biocompatibility evaluation of a new resilient, hard-carbon, thin-film coating for ventricular assist devices. Artificial Organs (in Press).

 
 
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