Health  Vol.2 No.5 , May 2010
Concurrent pulmonary Mycobacterium avium complex (MAC) infection and active Hürthle cell thyroid carcinoma: is there a connection?
Abstract: We present two cases of pulmonary MAC infection in women with Hürthle cell thyroid carcinoma. Both cases were asymptomatic octogenarian women with active Hürthle cell thyroid carcinoma and prolonged periods of hypothyroidism prior to diagnosis of pulmonary MAC. Mycobacterium avium complex has never been reported in association with any type of thyroid cancer, specifically Hürthle cell carcinoma. A review of the literature and possible associations between the two are discussed in this article.
Cite this paper: nullBaehr, K. and Goldner, W. (2010) Concurrent pulmonary Mycobacterium avium complex (MAC) infection and active Hürthle cell thyroid carcinoma: is there a connection?. Health, 2, 391-394. doi: 10.4236/health.2010.25058.

[1]   Watson, R., Brennan, M., Goellner, J., et al. (1984) Invasive Hürthle cell carcinoma of the thyroid: Natural history and management. Mayo Clinic Proceedings, 59(12), 851-855.

[2]   Grossman, R. and Clark, O. (1977) Hürthle cell carcinoma. Cancer Control, 4, 13-17.

[3]   Yutan, E. and Clark, O. (2001) Hürthle cell carcinoma. Current Treatment Options in Oncology, 2(4), 331-335.

[4]   Good, R. and Snider, D. (1982) Isolation of nontuberculous mycobacteria in the United States. Journal of Infectious Diseases, 146(6), 829-833.

[5]   Pallella, F. Jr., Delaney, K., Moorman, A., et al. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. New England Journal of Medicine, 338(13), 853-860.

[6]   Parrish, S., Myers, J. and Lazarus, A. (2008) Nontuberculous mycobacterial pulmonary infections in non-HIV patients. Postgraduate Medicine, 120(4), 78-86.

[7]   Erasmus, J., McAdams, H., Farrell, M. and Patz, E. Jr. (1999) Pulmonary nontuberculous mycobacterial infection: Radiologic manifestations. Radiographics, 19(6), 1487-1503.

[8]   Levin, D. (2002) Radiology of pulmonary Mycobacterium avium-intracellulare complex. Clinics in Chest Medicine, 23(3), 603-612.

[9]   Koh, W., Lee, K., Kwon, O., Jeong, Y., et al. (2005) Bilateral bronchiectasis and bronchiolitis at thin-section CT: Diagnostic implications in nontuberculous mycobacterial pulmonary infection. Radiology, 235(1), 282-288.

[10]   Olivier, K., Weber, D., Lee, J., et al. (2003) Nontuberculous mycobacteria I: Multicenter prevalence study in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 167(6), 828-834.

[11]   Hartman, T., Jensen, E., Tazelaar, H., Hanak, V. and Ryu, J. (2007) CT findings of granulomatous pneumonitis secondary to Mycobacterium avium-intracellulare inhalation: “Hot tub lung.” American Journal of Roentgenology, 188(4), 1050-1053.

[12]   Reich, J. and Johnson, R. (1992) Mycobacterium avium complex pulmonary disease presenting as an isolated lingular or middle lobe pattern: The Lady Windermere syndrome. Chest, 101(6), 1605-1609.

[13]   Prince, D., Peterson, D., Steiner, R., et al. (1989) Infection with Mycobacterium avium complex in patients without predisposing conditions. New England Journal of Medicine, 321(13), 863-868.

[14]   Huang, J., Kao, P., Adi, V. and Ruoss, S. (1999) Mycobacterium avium-intracellulare pulmonary infection in HIV-negative patients without preexisting lung disease. Chest, 115(4), 1033-1040.

[15]   Kim, R., Greenberg, D., Ehrmantraut, M., et al. (2008) Pulmonary nontuberculous mycobacterial disease. Ame- rican Journal of Respiratory and Critical Care Medicine, 178(10), 1066-1074.

[16]   Schoenfeld, P., Myers, J., Myers, L. and LaRocque, J. (1995) Suppression of cell-mediated immunity in hypothyroidism. Southern Medical Journal, 88(3), 347-349.

[17]   Fabris, N. (1973) Immunodepression in thyroid-deprived animals. Clinical & Experimental Immunology, 15(4), 601-611.

[18]   Tani, H., Nabetani, T., Sasai, K. and Baba, E. (2005) Proliferative responses to canine thyroglobulin of peripheral blood mononuclear cells from hypothyroid dogs. Journal of Veterinary Medical Science, 67(4), 363-368.

[19]   Mazzaferri, E. and Kloos, R. (2001) Current approaches to primary therapy for papillary and follicular cancer. Journal of Clinical Endocrinology & Metabolism, 86(4), 1447-1463.