ABSTRACT Zamzam water is well known of its high conductivity. For this fact urologist and nephrologists recommend their patients who are suffering from kidney stones not to drink this water because it could worse their health status. This study was conducted to investigate the effect of Zamzam water on calcium oxalate nephrotoxicity in experimentally induced kidney stones in male Wistar albino rats. Calcium oxalate crystals were induced by orally administration of 200 mg of glycolic acid dissolved in the drinking water. The rats were divided into three groups; six rats each. These include positive control group (given glycolic acid), test group (given glycolic acid plus Zamzam water) and negative group (given drinking water only). After two weeks of treatment, blood analysis of blood urea nitrogen (BUN) and creatinine showed significant differences in positive control group compared to the negative control group, whereas no significant differences were noticed in the level of BUN and creatinine between both the negative control and the test group. Moreover, urine analysis showed a high density of calcium oxalate crystals in the positive control group, whereas no crystals were detected in the negative control and the test groups. Histopathological investigations showed damaging in kidneys of the positive control group with no tissue abnormalities in the negative control and the test group. I concluded from this study that Zamzam water prevents the formation calcium oxalate stone, which probably mean that it has no negative effect on patients suffering from kidney disorders due to crystals formation.
Cite this paper
Al-Ghamdi, S. (2012) Inhibition of calcium oxalate nephrotoxicity with Zamzam water. Open Journal of Preventive Medicine, 2, 67-71. doi: 10.4236/ojpm.2012.21010.
 Koshak, Y.H. (1983) Zamzam. Dar Alelm for Publications, Jeddah.
Mashat, B.H. (2010) The Microbiological Quality of Sabil Free) Drinking Water in Makkah Al-Mukarramah. JKAU: Met. Env. & Arid Land Agric. Sci., 21, 87-100.
Al-Zuhair, A., Al-Ghamdi, H. and Noorwali, M. (2005) Analytical report of Zamzam water during the Ramadan and Hajj Seasons 1425H. The Institute of the Custodian of the Two Holy Mosques for Al Hajj Research Centre, Om Al Qura University, Makkah.
Parmar and Malvinder, S. (2004) Kidney stones. British Medical Journal, 328, 1420-1424.
Risal, S. (2006) Spectrum of stones composition. 2nd Edition, New York.
Macaluso, J.N. (1996) Management of stone disease-bearing the burden. The Journal of Urology, 156, 1579-1580. doi:10.1016/S0022-5347(01)65452-1
Trinchieri, A., Mandressi, A., Luongo, P., Longo, G. and Pisani, P. (1991) The influence of diet on urinary risk factors for stones in healthy subjects and idiopathic renal calcium stone formers. British Journal of Urology, 67, 230-236. doi:10.1111/j.1464-410X.1991.tb15124.x
Jaime, U., Oh, M.S. and Carroll, H.J. (1989) Diagnosis and treatment: The first kidney stone. Annals of Internal Medicine, 15, 1006-1009.
Kumar, S., Sigmon, D., Miller, T., Carpenter, B., Khan, S., Malhotra, R., Scheid, C. and Menon, M. (1991) A new model of nephrolithiasis involving tubular dysfunction/ injury. Journal of Urology, 146, 1384-1389.
Desmars, J.F. and Tawashi, R. (1973) Dissolution and growth of calcium oxalate monohydrate. I. Effect of magnesium and pH. Biochimica et Biophysica Acta (BBA), 313, 256-267. doi:10.1016/0304-4165(73)90025-1
Sai Sathish, R., Ranjit, B., Ganesh, K.M., Nageswara Rao, G. and Janardhana, C. (2008) A quantitative study on the chemical composition of renal stones and their fluoride content. Current Sciences, 94, 104-109.
Singh, P.P., Barjatiya, M.K, Dhing, S., Bhatnagar, R., Kothari, S. and Dhar, V. (2001) Evidence suggesting that high intake of fluoride provokes nephrolithiasis in tribal populations. Urological Research, 29, 238-244.