OJPM  Vol.2 No.1 , February 2012
Magnesium intervention and blood pressure—A study on risk groups
ABSTRACT
Hypothesis: Although mineral deficiency in particular magnesium is a known risk factor for cardiovascular disease intervention experiments with magnesium show only modest results. Previously published data suggest that there may be particular risk groups in the population. The study was undertaken to investigate if such risk groups could be identified. Experimental design: Subjects (n = 31) were 50 - 79 years old with no disease. The 24 hour urinary excretion of urea (proxy for acidity), magnesium, calcium, and potassium was measured at two week intervals, with and without intervention with mineral water. Intervention with mineral water comprised 75 mL daily, supplying 3.1 mmol Mg, 2.3 Ca, and 0.02 K. Major results: There was a significant relation between acidity and excretion of magnesium, calcium, and potassium, both at one occasion and regarding changes over time. Among subjects with a high secretion of urea there was an inverse relation between the excretion of magnesium and systolic blood pressure. After intervention with mineral water, there was a strong tendency to a decrease in the systolic blood pressure among those with an initial high excretion of urea and a low excretion of magnesium. Conclusions: The results demonstrate the importance of acid-base conditions for mineral homeostasis and suggest the presence of risk groups in the population, related either to a low intake or to a disorder in the reabsorbtion mechanisms. Mineral water decreased the systolic blood pressure in that particular risk group.

Cite this paper
Rylander, R. , Tallheden, T. and Vormann, J. (2012) Magnesium intervention and blood pressure—A study on risk groups. Open Journal of Preventive Medicine, 2, 23-26. doi: 10.4236/ojpm.2012.21004.
References
[1]   Mathers, T.W. and Beckstrand, R.L. (2009). Oral magnesium supplementation in adults with coronary heart disease or coronary heart disease risk. Journal of the American Academy of Nurse Practitioners, 21, 651-657. doi:10.1111/j.1745-7599.2009.00460.x

[2]   Hashimoto, T., Hara, A., Ohkubo, T., Kikuya, M., Shintani, Y., Metoki, H., Inoue, R., Asayama, K., Kanno, A., Nakashita, M., Terata, S., Obara, T., Hirose, T., Hoshi, H., Totsune, K., Satoh, H. and Imai, Y. (2010). Serum magnesium, ambulatory blood pressure, and carotid artery alterations: The Ohasama study. American Journal of Hypertension, 23, 1292-1298. doi:10.1038/ajh.2010.168

[3]   Yamon, Y. and Mizushima, S. (2000) A review of the link between dietary magnesium and cardiovascular risk. Journal of Cardiovascular Risk, 7, 31-35.

[4]   Peacock, J.M., Ohira, T., Post, W., Sotoodehnia, N., Rosamond, W. and Folsom, A.R.(2010) Serum magnesium and risk of sudden cardiac death in the atherosclerosis risk in communities (ARIC) study. American Heart Journal, 160, 464-470. doi:10.1016/j.ahj.2010.06.012

[5]   Rylander, R. (1996) Environmental magnesium deficiency as a cardiovascular risk factor. Journal of Cardiovascular Risk, 3, 4-10. doi:10.1097/00043798-199602000-00002

[6]   Rubenowitz, E., Molin, I., Axelsson, G. and Rylander, R. (2000) Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction. Epidemiology, 11, 416-421. doi:10.1097/00001648-200007000-00009

[7]   Catling, L.A., Abubakar, I., Lake, I.R., Swift, L. and Hunter, P.R. (2008) A systematic review of analytical observational studies investigating the association between crdiovascular disease and drinking water hardness. Journal of Water and Health, 4, 433-342. doi:10.2166/wh.2008.054

[8]   Jee, S.H., Miller, E.R., Guallar, E., Singh, V.K., Appel, L.J. and Klag, M.J. (2002) The effect of magnesium supplementation on blood pressure: A meta-analysis of randomized clinical trials. American Journal of Hypertension, 15, 691-696. doi:10.1016/S0895-7061(02)02964-3

[9]   Rylander, R. and Arnaud, M.J. (2004) Mineral water intake reduces blood pressure among subjects with low urinary magnesium and calcium levels. BMC Public Health, 4, 56-65. doi:10.1186/1471-2458-4-56

[10]   Leurs, L.L., Schouten, L.J., Mons, M.N., Goldbohm, R.A. and van den Brandt, P.A. (2009) Relationship between tap water hardness, magnesium, and calcium concentration and mortality due to ischemic heart disease or stroke in the Netherlands. Environmental Health Perspectives, 118, 414-420. doi:10.1289/ehp.0900782

[11]   Lind, L., Lithell, T. and Ljunghall, S. (1992) Blood pressure response during long-term treatment with magnesium is dependent on magnesium status. American Journal of Hypertension, 4, 674-679

[12]   Rouston, D., Hoare, J. and Gregory, J. (2004) The national diet and nutrition survey: Adults aged 19 - 64. The Stationery Office, London.

[13]   Rylander, R., Remer, T., Berkemeyer, S. and Vormann, J. (2006) Relationship of magnesium and acid-base balance in an elderly population. European Journal of Nutrition, 36, 2374-2377.

[14]   Remer, T., Berkemeyer, S., Rylander, R. and Vormann, J. (2007) Muscularity and adiposity in addition to net acid excretion as predictors of 24-h urinary pH in young adults and elderly. European Journal of Clinical Nutrition, 61, 605-609.

[15]   Rylander, R., Tallheden, T. and Vormann, J. (2009) Acid-base conditions regulate calcium and magnesium homeostasis. Magnesium Research, 22, 1-4.

[16]   Remer, T. (2001) Influence of nutrition on acid-base balance—metabolic aspects. European Journal of Nutrition, 40, 214-220. doi:10.1007/s394-001-8348-1

 
 
Top