[1] Yiu, H.-Y., Whittemore, A.S. and Shibata, A. (2004) Increasing colorectal cancer incidence rates in Japan. International Journal of cancer, 109, 777-781. doi:10.1002/ijc.20030
[2] Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J. and Thun, M.J. (2007) Cancer statistics, 2007. CA: A Cancer Journal for Clinicians, 57, 43-66. doi:10.3322/canjclin.57.1.43
[3] Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Ber-lin, J., Baron, A., Griffing, S., Holmgren, E., Ferrara, N., Fyfe, G., Rogers, B., Ross, R. and Kabbinavar, F. (2004) Bevacizmub plus irinotechan, fluorouracil, and leucovorin for metastatic co-lorecatal cancer. The New England Journal of Medicine, 350, 2335-2342. doi:10.1056/NEJMoa032691
[4] Meyerhardt, J.A. and Mayer, R.J. (2005) Systemic therapy for colorectal cancer. The New England Journal of Medicine, 352, 476-487. doi:10.1056/NEJMra040958
[5] Cassileth, B., Yeung, K.S. and Gubili, J. (2008) Herbs and other botanicals in cancer patient care. Current Treat- ment Options in Oncology, 9, 109-116. doi:10.1007/s11864-008-0061-5
[6] Surh, Y.J. (2003) Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer, 3, 768-780. doi:10.1038/nrc1189
[7] Berger, D., Schaffner, W., Schrader, E., Meier, B. and Brattstr?m, A. (2000) Efficacy of Vitex ag-nus-castus L extract Ze 440 in patients with pre-menstrual syn-drome (PMS). Archives of Gynecology and Obstetrics, 264, 150- 153. doi:10.1007/s004040000123
[8] Schellenberg, R. (2001) Treatment for the premenstrual syndrome with agnus castus fruit extract: Prospective, randomized, placebo controlled study. British Medical Jour- nal, 322, 134-137. doi:10.1136/bmj.322.7279.134
[9] Hirobe, C., Qiao, Z-S., Takeya, K. and Itokawa, H. (1997) Cytotoxic flavonoids from Vitex agnus-castus. Phytoche- mistry, 46, 521-524. doi:10.1016/S0031-9422(97)00127-1
[10] Ohyama, K., Akaike, T., Imai, M., Toyoda, H., Hirobe, C. and Bessho, T. (2005) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress. The International Journal of Biochemistry & Cell Biology, 37, 1496-1510. doi:10.1016/j.biocel.2005.02.016
[11] Ohyama, K., Akaike, T., Hirobe, C. and Yamakawa, T. (2003) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruits extract in cultured human normal and cancer cells and effect on growth. Biological & Pharmaceutical Bulletin, 26, 10-18. doi:10.1248/bpb.26.10
[12] Imai, M., Kikuchi, H., Denda, T., Ohyama, K., Hirobe, C. and Toyoda, H. (2009) Cytotoxic ef-fects of flavonoids against a human colon cancer derived cell line, COLO 201: A potential natural anti-cancer substance. Cancer Letters, 276, 74-80. doi:10.1016/j.canlet.2008.10.036
[13] Imai, M., Kikuchi, H., Yuan, B., Aihara, Y., Mizokuchi, A., Ohyama, K., Hirobe, C. and Toyoda, H. (2011) Enhanced growth inhibitory effect of 5-fluorouracil in combination with Vitex agnus-castus fruits extract against a human colon adeno-carcinoma cell line, COLO 201. Jour- nal of Chinese Clinical Medicine, 6, 14-19. http://www.cjmed.net/index.php/cjmed/article/view/109
[14] Semple, T.U., Quinn, L.A., Woods, L.K. and Moore, G.E. (1978) Tomor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model. Cancer Research, 38, 1345-1355. http://cancerres.aacrjournals.org/content/38/5/1345
[15] Takeuchi, R., Tsutsumi, H., Osaki, M., Haseyama, K., Mizue, N. and Chiba, S. (1998) Respiratory syncytial virus infection of human alveolar epithelial cells enhances interferon regulatory factor 1 and interleukin-1β-conver- ting enzyme gene expression but does not cause apoptosis. The Journal of Virology, 72, 4498-4502. http://jvi.asm.org/content/72/5/4498.full
[16] Dubrovskaya, V.A. and Wetterhahn, K.E. (1998) Effects of Cr (VI) on the expression of the oxidative stress genes in human lung cells. Carcinogenesis, 19, 1401-1407. doi:10.1093/carcin/19.8.1401
[17] Tajiri, S., Oyadomari, S., Yano, S., Morioka, M., Gotoh, T., Hamada, J.I., Ushio, Y. and Mori, M. (2004) Ischemia-induced neuronal cell death is me-diated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death & Differentiation, 11, 403-415. doi:10.1038/sj.cdd.4401365
[18] Inoue, J. and Aramaki, Y. (2007) Cyclooxygenase-2 inhibitor promotes enhancement of antitumor responses by transcutaneous vaccination with cyto-sine-phosphate- gua- nosine-oligodeoxynucleotides and model tumor antigen. Journal of Investigative Dermatology, 127, 614-621. doi:10.1038/sj.jid.5700656
[19] Wada, T. and Penninger, J.M. (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene, 23, 2838- 2849. doi:10.1038/sj.onc.1207556
[20] Li, J. and Holbrook, N.J. (2004) Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensi-tizes aged cells to ER stress. Experimental Gerontology, 39, 735-744. doi:10.1016/j.exger.2004.02.008
[21] Lee, H.J., Wang, C.J., Kuo, H.C., Chou, F.P., Jean, L.F. and Tseng, T.H. (2005) Induc-tion apoptosis of luteolin in human hepatoma HepG2 cells in-volving mitochondria translocation of Bax/Bak and activation of JNK. Toxicology and Applied Pharmacology, 203, 124-131. doi:10.1016/j.taap.2004.08.004
[22] Yang, S.-H., Chien, C.-M., Chang, L.-S. and Lin, S.-R. (2007) Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apop-tosis induced by cardiotoxin III (Naja naja atra) in K562 leu-kemia cells. To- xicon, 49, 966-974. doi:10.1016/j.toxicon.2007.01.005
[23] Feng, Q., Cao, H.L., Xu, W., Li, X.R., Ren, Y.Q. and Du, L.F. (2011) Apoptosis induced by genipin in human leukemia K562 cells: Involvement of c-Jun N-terminal ki- nase in G2/M arrest. Acta Pharmacolo-gica Sinica, 32, 519-527. doi:10.1038/aps.2010.158
[24] Kang, S.J., Kim, B.M., Lee, Y.J., Hong, S.H. and Chung, H.W. (2009) Titanium dioxide nanoparticles induce apop- tosis through the JNK/p38-caspase-8-Bid pathway in phytohemaggluti-nin-stimulated human lymphocytes. Biochemi- cal and Biophysi-cal Research Communications, 386, 682- 687. doi:10.1016/j.bbrc.2009.06.097
[25] Boisvieux-Ulrich, E., Sourdeval, M. and Marano, F. (2005) CD437, a synthetic reti-noid, induces apoptosis in human respiratory epithelial cells via caspase-indepen- dent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway. Experi-mental Cell Research, 307, 76-90. doi:10.1016/j.yexcr.2005.02.005
[26] Deng, Y., Ren, X., Yang, L., Lin, Y. and Wu, X. (2003) A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell, 115, 61-70. doi:10.1016/S0092-8674(03)00757-8
[27] Butt, A.J., Dickson, K.A., Jambazov, S. and Baxter, R.C. (2005) Enhancement of tumor necrosis factor-alpha-in- duced growth inhibition by insulin-like growth factor- binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells. Endocrinology, 146, 3113-3122. doi:10.1210/en.2004-1408
[28] Kim, H.P., Pae, H.O., Back, S.H., Chung, S.W., Woo, J.M., Son, Y. and Chung, H.T. (2011) Heme oxygenase-1 comes back to endoplasmic reticulum. Bi-ochemical and Biophysical Research Communications, 404, 1-5. doi:10.1016/j.bbrc.2010.11.067
[29] Liu, X.M., Peyton, K.J., Ensenat, D., Wang, H., Schafer, A.I., Alam, J. and Durante, W. (2005) Endoplasmic reticulum stress stimulates heme oxyge-nase-1 gene expression in vascular smooth muscle. Role in cell survival. The Journal of Biological Chemistry, 280, 872-877. doi:10.1074/jbc.M410413200
[30] Berridge, M.J. (2002) The endoplasmic reticulum: A multifunctional signaling organelle. Cell Calcium, 32, 235- 249. doi:10.1016/S0143416002001823
[31] Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H.P. and Ron, D. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science, 287, 664-666. doi:10.1126/science.287.5453.664
[32] Yoneda, T., Imaizumi, K., Oono, K., Yui, D., Gomi, F., Katayama, T. and Tohyama, M. (2001) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor recep-tor-associated factor 2-dependent mechanism in response to the ER stress. The Journal of Biological Chemistry, 276, 13935-13940. doi:10.1074/jbc.M010677200
[33] Kurisu, J., Honma, A., Miyajima, H., Kondo, S., Okumura, M. and Imaizumi, K. (2003) MDG1/ERdj4, an ER- resident DnaJ family member, suppresses cell death induced by ER stress. Genes to Cells, 8, 189-202. doi:10.1046/j.1365-2443.2003.00625.x
[34] Zhou, Y., Liu, Y.E., Cao, J., Zeng, G., Shen, C., Li, Y., Zhou, M., Chen, Y., Pu, W., Potters, L. and Shi, Y.E. (2009) Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clinical Cancer Research, 15, 5161-5169. doi:10.1158/1078-0432.CCR-09-0661