JCT  Vol.3 No.1 , February 2012
Chemotherapy-Knowledge and Handling Practice of Nurses Working in a Medical University of Nepal
ABSTRACT
Background: Many antineoplastic agents are known to be teratogenic and mutagenic to humans. Nurses are the main groups that are exposed to these drugs in hospital setting. Generally, the occupational activities that pose to greatest risk of exposure are the preparation and administration of antineoplastic agents, cleaning of chemotherapy spills, and handling of patient excreta. Objective: The objectives of this study were to evaluate the knowledge of nurse regarding the way of exposure of Cytotoxic Drugs (CDs) and to determine the current patterns of use of personal protective equipments while handling antineoplastic chemotherapeutic agents. Methods: An analytic cross sectional study was carried out at BPKIHS Dharan. The study was carried out on 125 nurses. The random sampling technique was used to select the study subjects using structured and semi-structured questionnaire. Collected data were analyzed using descriptive and inferential statistics. Result: More than 92% of participants reported usually wearing gloves during chemotherapy handling; 6% reported using laboratory coats as protective garments. Usual use of face and respiratory protection was less than 5%. Chemotherapy was reported to be prepared in nursing station where there are no laminar airflow hoods in 100% of work settings. None of the subjects have reportedly provided any type of medical monitoring. Conclusion: Use and availability of gloves have increased but personal protective equipment like protective garments, face and respiratory protective, when handling chemotherapy have decreased and medical monitoring of exposed employees still is neither widely practiced nor consistent with Occupational Safety and Health Administration (OSHA) guidelines.

Cite this paper
R. Chaudhary and B. Karn, "Chemotherapy-Knowledge and Handling Practice of Nurses Working in a Medical University of Nepal," Journal of Cancer Therapy, Vol. 3 No. 1, 2012, pp. 110-114. doi: 10.4236/jct.2012.31014.
References
[1]   S. Ben-Ami, J. Shaham, S. Rabin, A. Melzer and J. Ribak, “The Influence of Nurses’ Knowledge, Attitude, and Health Believe on their Safe Behaviour with Cytotoxic Drugs in Israel,” Cancer Nursing, Vol. 24, No. 3, 2001, pp. 192-200. doi:10.1097/00002820-200106000-00005

[2]   S. Burgaz and B. Karahalil, “Urinary Cyclophosphamide Excertion and Micronuclei Frequencies Lymphocytes and in Exfoliated Buccal Epithelial Cells of Nurses Handling Antineoplastics,” Mutation Research, Vol. 439, No. 1, 1999, pp. 97-104.

[3]   S. Ensslin Angela, R. Huber and P. Angelika, “Biological Monitoring of Hospital Pharmacy Personnel Occupationally Exposed to Cytostatic Drugs: Urinary Excretion and Cytogenetic Study,” International Archives of Occupational Environmental Health, Vol. 70, No. 3, 1997, pp. 205-258. doi:10.1007/s004200050208

[4]   C. Vollono, G. Badoni and G. Petrelli “Risk Perception and Self Assessment of Exposure to Antineoplastic Agents in a Group of Nurses and Pharmacists,” Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 24, No. 1, 2002, pp. 49-55.

[5]   P. J. Sessink, B. C. Wittenhorst, R. B. Anzion and R. P. Bos, “Exposure of Pharmacy Technicians to Antineoplastic Agents; Reevaluation after Additional Protective Measures,” Archives of Environmental Health, Vol. 52, No. 3, 1997, pp. 240-244. doi:10.1080/00039899709602893

[6]   E. Nygren and C. Lundgren, “Determination of Platinum in Workroom Air and in Blood and Urine from Nursing Staff Attending Patients Receiving Cisplatin Chemotherapy,” International Archives of Occupational Environmental Health, Vol. 70, No. 3, 1997, pp. 209-214. doi:10.1007/s004200050209

[7]   OSHA Technical Manual, “Controlling Occupational Exposure to Hazardous Drugs,” 5th Edition, OSHA Publication, Washington DC, 1999.

[8]   G. Kubilay and H. Fesci Erdem, “Evaluation of the Status of the Nurses Preparing and Administrating CDs,” Oncology Nurses’ Association, Vol. 6, 1997, pp. 7-15.

[9]   C. Habib and S. Karam, “Handling of Antineoplastic Products and Nurses’ Knowledge,” Le Journal Medical Libanais, Vol. 40, No. 4, 1992, pp. 182-186.

[10]   International Agency for Research on Cancer (IARC), “IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans: Some Antineoplastic and Immunosuppressive Agents,” Vol. 26, IARC, Lyon, 1981, pp. 370-384.

[11]   S. Krstev, B. Perunicic and A. Vidakovic, “Work Practice and Some Adverse Health Effects in Nurses Handling Antineoplastic Drugs,” Le Medicina del Lavoro, Vol. 94, No. 4, 2003, pp. 432-439.

[12]   S. Martin, E. Larson, “Chemotherapy-Handling Practices of Outpatient and Office-Based Oncology Nurses,” Oncology Nursing Forum, Vol. 30, No. 4, 2003, pp. 575-581. doi:10.1188/03.ONF.575-581

[13]   G. Aydemir, N. Sogukpinar and E. Turkistanli, “Prevention and Health Education: How Recent Advances in the Science and Art of Health Education Have Been Applied in Practical Ways within Medical and Other Settings for Prevention of Public Health,” Asian Pacific Journal of Cancer Prevention, Vo. 4, No. 1, 2003, pp. 71-74.

[14]   S. Mastour, Al-Ghamdi, H. Zaki and Al-Mustafa, “The Handling of Anticancer Drugs in Riyadh and the Eastern Province,” Annals of Saudi Medicine, Vol. 17, No. 2, 1997, pp. 257-259.

[15]   C. Schreiber, K. Radon K, A. Pethran, R. Schierl, K. Hauff, C. H. Grimm, et al., “Uptake of Antineoplastic Agents in Pharmacy Personnel, Part II: Study of Work Related Risk Factors,” International Archives of Occupational and Environmental Health, Vol. 76, No. 1, 2002, p. 11.

[16]   G. Micoli, R. Turci, M. Arpellini and C. Monia, “Determination of 5-Fluorouracil in Environmental Samples by Solid-phase Extraction and High-Performance Liquid Chromatography with Ultraviolet Detection,” Journal of Chromatography, Vol. 50, No. 1, 2001, pp. 25-32.

[17]   P. J. Sessink, K. A. Boer, A. P. Scheefhals, R. B. Anzion and R. P. Bos, “Occupational Exposure to Antineoplastic Agents at Several Departments in a Hospital. Environmental Contamination and Excretion of Cyclophosphamide and Ifosfamide in Urine of Exposed Workers,” International Archives of Occupational and Environmental Health, Vol. 64, No. 2, 1992, pp. 105-112. doi:10.1007/BF00381477

[18]   P. J. Sessink, M. C. Van de Kerkhof and R. B. Anzion, “Environmental Contamination and Assessment of Exposure to Antineoplastic Agents by Determination of Cyclophosphamide in Urine of Exposed Pharmacy Technicians: Is Skin Absorption an Important Exposure Route?” Archives of Environmental Health, Vol. 49, No. 3, 1994, pp. 165-169. doi:10.1080/00039896.1994.9940377

[19]   P. J. Sessink, A. J. Verplanke, R. F. Herber and R. P. Bos, “Occupational Exposure to Antineoplastic Agents and Parameters for Renal Dysfunction,” International Archives of Occupational and Environmental Health, Vol. 69, No. 3, 1997, pp. 215-218. doi:10.1007/s004200050139

 
 
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