OJGas  Vol.2 No.1 , February 2012
The effect of NAFLD (non-alcoholic fatty liver disease) on long-term outcome of chronic hepatitis B in Iranian patients
ABSTRACT
Background: The influence of Non-Alcoholic Fatty Liver Disease on the outcome of chronic hepatitis B disease, including viral, biochemical and histologic characteristics, in Iranian patients is not yet fully un- derstood. Aim: To evaluate the effect of Non-Alcoholic Fatty Liver Disease (NAFLD) on long-term histology- cal, biochemical and viral outcome of chronic he- pa-tictis B in Iranian patients. Methods: We retro- spec-tively evaluated 94 “e Ag” negative chronic hepatitis B patients (with NAFLD: 44, without NAFLD: 50). Non-Alcoholic Fatty Liver Disease was diagnosed based on liver biopsy according to Kleiner classifica-tion. Liver biopsy was done for all patients. Serologi-cal and biochemical variables were evaluated with repeated measure analysis. Results: Non-Alcoholic Fat- ty Liver Disease (NAFLD) was present in 47% of the patients (44 out of 94 patients). In the NAFLD group, increase in AST, ALT, stage (P = 0.002), grade, and total score of liver biopsy were independently related to non-alcoholic fatty liver disease, while HBV-DNA viral load did not correlate with the presence of a fatty liver. Conclusion: Abnormalities of liver enzymes and liver histopathology are more prevalent in concurrent chronic hepatitis B and Non-Alcoholic Fatty Liver Disease (NAFLD).

Cite this paper
Estakhri, A. , Sari, A. , Nedjat, S. , Rohban, M. , Rakhshani, N. , Tavangar, S. , Malekzadeh, R. and Montazeri, G. (2012) The effect of NAFLD (non-alcoholic fatty liver disease) on long-term outcome of chronic hepatitis B in Iranian patients. Open Journal of Gastroenterology, 2, 18-21. doi: 10.4236/ojgas.2012.21004.
References
[1]   Bondini, S. and Kallman, J. (2007) Impact of non-alco- holic fatty liver disease on chronic hepatitis B. Liver International, 27, 607-611. doi:10.1111/j.1478-3231.2007.01482.x

[2]   Ganem, D. and Prince, A.M. (2004) Hepatitis B virus in- fection-natural history and clinical consequences. The New England Journal of Medicine, 350, 1118-1129. doi:10.1056/NEJMra031087

[3]   Tran, T.T. and Martin, P. (2004) Hepatitis B: Epidemiol- ogy and natural history. Clinical Liver Disease, 8, 255- 266. doi:10.1016/j.cld.2004.02.008

[4]   Altiparmak, E. and Koklu, S. (2005) Viral and host causes of fatty liver in chronic hepatitis B. World Journal of Gastroenterology, 11, 3056-3059.

[5]   Stephen, A. and Harrison, M. (2002) Nonal-coholic steatohepatitis: What we know in the new Millennium. The American Journal of Gastroenterology, 97, 2714-2724.

[6]   Tsang, S.W.C. and Ng, W.F. (2006) Predic-tors of fibrosis in Asian patients with non-alcoholic steatohepa-titis. Jour- nal of Gastroenterology and Hepatology, 21, 116-121. doi:10.1111/j.1440-1746.2005.04146.x

[7]   Younossi, Z.M. and Deihl, A.M. (2000) Nonalcoholic fat- ty liver disease: An agenda for clinical research. Hepatol- ogy, 35, 746-752. doi:10.1053/jhep.2002.32483

[8]   Gordon, A. and McLean, C.A. (2005) Hepatic steatosis in chronic hepatitis B and C: Predictors, distribution and ef- fect on fibrosis. Journal of He-patology, 43, 38-44. doi:10.1016/j.jhep.2005.01.031

[9]   Lonardo, A. and Adinolfi, L.E. (2004) Steatosis and he- patitis C virus: Mechanismsm and significance for hepa- tic and extrahepatic disease. Gastroen-terology, 126, 586- 597. doi:10.1053/j.gastro.2003.11.020

[10]   Ong, J.P. and Younossi, Z.M. (2001) Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. Liver, 21, 266-271. doi:10.1034/j.1600-0676.2001.021004266.x

[11]   Adinolfi, L.E. and Gambardella, M. (2001) Steatosis ac- celerates the pro-gression of liver damage of chronic he- patitis C patients and correlated with specific HCV geno- type and visceral obesity. Hepatology, 33, 1358-1364. doi:10.1053/jhep.2001.24432

[12]   Chevaliez, S. and Bouvi-er-Alias, M. (2008) Performance of the cobas ampliprep/cobas taqman real-time PCR as- say for hepatitis B virus DNA quan-tification. Journal of clinical Microbiology, 46, 1716-1723. doi:10.1128/JCM.01248-07

[13]   Kleiner, D.E. and Brunt, E.M. (2005) Design and valida- tion of a histological scoring system for nonalcoholic fatty liver disease. Hepatology, 41, 1313-1321. doi:10.1002/hep.20701

[14]   Bahramali, G. and Sadeghizadeh, M. (2008) Clinical, vir- ological and phylogenetic features of hepatitis Binfection in Iranian patients. World Journal of Gas-troenterology, 14, 448-453

[15]   Westin, J. and Nordlinder, H. (2002) Steatosis accelerates fibrosis development over time in hepatitis c virus geno- type 3 infected patients. Journal of He-patology, 37, 837- 842. doi:10.1016/S0168-8278(02)00299-4

[16]   Wong, G.L.-H. and Wong, V.W.-S. (2009) Metabolic syn- drome increases the risk of liver cirrhosis in chronic he- patitis B. Gut, 58, 111-117. doi:10.1136/gut.2008.157735

[17]   Powell, E.E. and Jonsson, J.R. (2005) Steatosis: Co-factor in other liver diseases. Hepa-tology, 42, 5-13. doi:10.1002/hep.20750

[18]   Thomopoulos, K.C. and Arvaniti, V. (2006) Prevalence of liver steatosis in patients with chronic hepatitis B. Euro- pean Journal of Gastroenterology & Hepa-tology, 18, 233- 237. doi:10.1097/00042737-200603000-00002

[19]   Altlparmak, E. and Koklu, S. (2005) Viral and host causes of fatty liver in chronic hepatitis B. World Journal of Gastroenterology, 11, 3056-3059.

 
 
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