OJBIPHY  Vol.2 No.1 , January 2012
Some No Longer Unknowns in Science
Abstract: Three out of 125 “big questions of science”, can now be claimed to have been answered. All of these questions involve water; its structure, its role in protein folding and its role in protein-protein association.
Cite this paper: A. Ben-Naim, "Some No Longer Unknowns in Science," Open Journal of Biophysics, Vol. 2 No. 1, 2012, pp. 1-3. doi: 10.4236/ojbiphy.2012.21001.

[1]   D. Kennedy and C. Norman, “What Don’t We Know?” Science, Vol. 309, No. 5731, 2005, p. 75. doi:10.1126/science.309.5731.75

[2]   A. Ben-Naim, “Molecular Theory of Water and Aqueous Solutions, Part I: Understanding Water,” World Scientific, Singapore, 2009. doi:10.1142/9789812837615

[3]   A. Ben-Naim, “Molecular Theory of Water and Aqueous Solutions: Part II The Role of Water in Protein Folding Self Assembly and Molecular Recognition,” World Scientific, Singapore, 2011.

[4]   C. Levinthal, “Are There Pathways for Protein Folding,” Journal de Chimie Physique, Vol. 65, No. 1, 1968, pp. 44-45.

[5]   C. Levinthal, “Mossbauer Spectroscopy in Biological Systems,” J. T. P. De Brunner and E. Munck, Eds., University of Illinois Press, 1969, pp. 22-24.

[6]   C. B. Anfinsen, “Principles that Govern the Folding of Protein Chains,” Science, Vol. 181, No. 4096, 1973, pp. 223-230. doi:10.1126/science.181.4096.223

[7]   A. Ben-Naim, “Pitfalls in Anfinsen’s Thermodynamic Hypothesis,” Chemical Physics Letters, Vol. 511, No. 1-3, 2011, pp. 126-128. doi:10.1016/j.cplett.2011.05.049

[8]   R. Zwanzig, A. Szabo and B. Bagchi, “Levinthal’s Paradox,” Proceedings of the National Academy of Science, Vol. 89, No. 1, 1992, pp. 20-22. doi:10.1073/pnas.89.1.20

[9]   W. Kauzmann, “Some Factors in the Interpretation of Protein Denaturation,” Advances in Protein Chemistry, Vol. 14, 1959, pp. 1-63. doi:10.1016/S0065-3233(08)60608-7

[10]   A. Ben-Naim, “Strong Forces between Hydrophilic Macromolecules; Implications in Biological Systems,” Journal of Chemical Physics, Vol. 93, No, 25, 1991, pp. 8196- 8210.

[11]   A. Ben-Naim, “Solvent Effects on Protein Association and Protein Folding,” Biopolymers, Vol. 29, No. 3, 1990, pp. 567-596. doi:10.1002/bip.360290312

[12]   A. Ben-Naim, “Molecular Recognition-Viewed Through the Eyes of the Solvent,” Biophysical Chemistry, Vol. 101-102, No. 10, 2002, pp. 309-319. doi:10.1016/S0301-4622(02)00165-5

[13]   A. Ben-Naim, “On the Driving Forces for Protein-Protein Association,” Journal of Chemical Physics, Vol. 125, No, 2, 2006, pp. 1-10.

[14]   H. Wang and A. Ben-Naim, “Solvation and Solubility of Globular Proteins,” Journal of Physical Chemistry B, Vol. 101, No, 6, 1997, pp. 1077-1086. doi:10.1021/jp961591b