Statistical Methods of SNP Data Analysis and Applications

Alexander  Bulinski; Oleg  Butkovsky; Victor  Sadovnichy; Alexey  Shashkin; Pavel  Yaskov; Alexander  Balatskiy; Larisa  Samokhodskaya; Vsevolod  Tkachuk

doi:10.4236/ojs.2012.21008

OJS Vol.2 No.1 , January 2012

Statistical Methods of SNP Data Analysis and Applications

Alexander Bulinski, Oleg Butkovsky, Victor Sadovnichy, Alexey Shashkin, Pavel Yaskov, Alexander Balatskiy, Larisa Samokhodskaya, Vsevolod Tkachuk

Abstract: We develop various statistical methods important for multidimensional genetic data analysis. Theorems justifying application of these methods are established. We concentrate on the multifactor dimensionality reduction, logic regression, random forests, stochastic gradient boosting along with their new modifications. We use complementary approaches to study the risk of complex diseases such as cardiovascular ones. The roles of certain combinations of single nucleotide polymorphisms and non-genetic risk factors are examined. To perform the data analysis concerning the coronary heart disease and myocardial infarction the Lomonosov Moscow State University supercomputer “Chebyshev” was employed.

Keywords: Genetic Data Statistical Analysis; Multifactor Dimensionality Reduction; Ternary Logic Regression; Random Forests; Stochastic Gradient Boosting; Independent Rule; Single Nucleotide Polymorphisms; Coronary Heart Disease; Myocardial Infarction

Cite this paper: A. Bulinski, O. Butkovsky, V. Sadovnichy, A. Shashkin, P. Yaskov, A. Balatskiy, L. Samokhodskaya and V. Tkachuk, "Statistical Methods of SNP Data Analysis and Applications," Open Journal of Statistics, Vol. 2 No. 1, 2012, pp. 73-87. doi: 10.4236/ojs.2012.21008.

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