Corrosion and Biocompatibility Assessment of Magnesium Alloys
Affiliation(s)
Department of Mechanical and Materials Engineering, Florida International University, Florida, USA.
Department of Mechanical and Materials Engineering, Florida International University, Florida, USA.
ABSTRACT
Magnesium due to its good biocompatibility, mechanical properties, necessity in metabolic processes and lightness in weight, is an ideal candidate for biodegradable implants. The major concerns with magnesium and its alloys are that of rapid and non-uniform corrosion. In this investigation, magnesium based binary, ternary and quaternary alloys were studied for their corrosion resistance and biocompatibility. In vitro corrosion resistance of the alloys was studied in accordance with ASTM G 102-89in phosphate buffered saline (PBS) at 37°C. The surface morphology of the alloys was studied using scanning electron microscopy (SEM) and the wettability of the alloys was determined by contact angle measurements. Additionally, the cytotoxicity of the leached metal ions on the viability of osteoblast was evaluated bysulforhodamine B (SRB) assay.
Magnesium due to its good biocompatibility, mechanical properties, necessity in metabolic processes and lightness in weight, is an ideal candidate for biodegradable implants. The major concerns with magnesium and its alloys are that of rapid and non-uniform corrosion. In this investigation, magnesium based binary, ternary and quaternary alloys were studied for their corrosion resistance and biocompatibility. In vitro corrosion resistance of the alloys was studied in accordance with ASTM G 102-89in phosphate buffered saline (PBS) at 37°C. The surface morphology of the alloys was studied using scanning electron microscopy (SEM) and the wettability of the alloys was determined by contact angle measurements. Additionally, the cytotoxicity of the leached metal ions on the viability of osteoblast was evaluated bysulforhodamine B (SRB) assay.
Cite this paper
P. Gill, N. Munroe, R. Dua and S. Ramaswamy, "Corrosion and Biocompatibility Assessment of Magnesium Alloys," Journal of Biomaterials and Nanobiotechnology, Vol. 3 No. 1, 2012, pp. 10-13. doi: 10.4236/jbnb.2012.31002.
P. Gill, N. Munroe, R. Dua and S. Ramaswamy, "Corrosion and Biocompatibility Assessment of Magnesium Alloys," Journal of Biomaterials and Nanobiotechnology, Vol. 3 No. 1, 2012, pp. 10-13. doi: 10.4236/jbnb.2012.31002.
References
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[1] Y. Wang, C. S. Lim, C. V. Lim, M. S. Yong, E. K. Teo and L. N. Moh, “In Vitro Degradation Behavior of M1A Magnesium Alloy in Protein-Containing Simulated Body Fluid,” Materials Science and Engineering C, Vol. 31, No. 8, 2011, pp. 579-587. doi:10.1016/j.msec.2010.11.017 [2] F. Witte, N. Hort, C. Vogt, S. Cohen, K. Ulrich Kainer, R. Willumeit and F. Feyerabend, “Degradable Biomaterials Based on Magnesium Corrosion,” Current Options in Solid State and Materials Science, Vol. 12, No. 5-6, 2008, pp. 63-72. [3] G. L. Song and A. Atrens, “Corrosion Mechanisms of Magnesium Alloys,” Advanced Engineering Materials, Vol. 1, No. 1, 1999, pp. 11-33. doi:10.1002/(SICI)1527-2648(199909)1:1<11::AID-ADEM11>3.0.CO;2-N [4] S. Whang, “Article 21—How does our Body Maintain Health,” Science and Health Series, Alkalife, 2011. [5] American Society for Testing and Materials, “Standard Practice for Calculation of Corrosion Rates and Related Information from Electrochemical Measurements,” ASTM, West Conshohocken, G102-89, 1999. [6] Q. Peng, X. Hou, L. Wang, Y. Wu, Z. Cao and L. Wang, “Microstructure and Mechanical Properties of High Performance Mg-Gd Based Alloys,” Materials & Design, Vol. 30, No. 2, 2009, pp. 292-296