WJCD  Vol.2 No.1 , January 2012
Rapid reversibility of Takotsubo cardiomyopathy
Background: In Takotsubo cardiomyopathy (TCM), left ventricular dysfunction is usually reversible within a few weeks. Complete recovery can however be very rapid. We report the case of Mrs. TA, a 53 year old patient who had a history of hypertension treated with atenolol and captopril. She was admitted with the diagnosis of non ST segment elevation myo-cardial infarction. The electrocardiogram showed anterior sub and the troponinI level was 3.48 mg/l. Echo-cardiography revealed a left ventricular (LV) ballooning and LV ejection fraction was 36%. A recent emotional stress was mentioned. TCM was suspected and emergency angiography showed apical ballooning with a normal coronary angiogram. There was a complete recovery in 72 hours with a normalization of regional and global LV function at echocardiography and angiography. Conclusion: There is a large variability in TCM evolution aspects probably due to a variable physiopathological mechanism which remains to be clarified.

Cite this paper
Zghal, F. , Trabelsi, R. , Mbarki, S. , Mourali, M. and Mechmeche, R. (2012) Rapid reversibility of Takotsubo cardiomyopathy. World Journal of Cardiovascular Diseases, 2, 26-28. doi: 10.4236/wjcd.2012.21005.
[1]   Prasad, A., Lerman, A. and Rihal, C.S. (2008) Apical ballooning syndrome (Tako-Tsubo or stress cardiomio- pathy): A mimic of acute myocardial infarction. American Heart Journal, 155, 408-417. doi:10.1016/j.ahj.2007.11.008

[2]   Gianni, M., Dentali, F., Grandi, A.M., et al. (2006) Apical ballooning syndrome or Takotsubo cardiomyopathy: A systematic review. European Heart Journal, 27, 1523- 1529. doi:10.1093/eurheartj/ehl032

[3]   Donohue, D. and Movahed, M.R. (2005) Clinical characteristics, demographics, and prog-nosis of transient left ventricular apical ballooning syndrome. Heart Failure Reviews, 10, 311-316. doi:10.1007/s10741-005-8555-8

[4]   Wittstein, I.S., Thiemann, D.R., Lima, J.A., et al. (2005) Neurohumoral features of myo-cardial stunning due to su- dden emotional stress. New England Journal of Medicine, 352, 539-548. doi:10.1056/NEJMoa043046

[5]   Park, J.H., Kang, S.J., Song, J.K., et al. (2005) Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest, 128, 296- 302. doi:10.1378/chest.128.1.296

[6]   Desmet, W.J., Adriaenssens, B.F. and Dens, J.A. (2003) Apical ballooning of the left ventricle: first series in white patients. Heart, 89, 1027-1031. doi:10.1136/heart.89.9.1027

[7]   Kurisu, S., Inoue, I., Kawagoe, T., et al. (2006) Persistent left ventricular dysfunction in Takotsubo cardiomyopathy after pacemaker implantation. Circulation Journal, 70, 641- 644. doi:10.1253/circj.70.641

[8]   Kurisu, S., Innoue, I., Kawagoe, T., et al. (2007) Documentation of early improvement of left ventricular function in Takotsubo cardiomyopathy. International Journal of Cardiology, 114, e70-e72. doi:10.1016/j.ijcard.2006.07.203

[9]   Sharkey, S.W., Lesser, J.R., Zenovich, A.G., et al. (2005) Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation, 111, 472- 479. doi:10.1161/01.CIR.0000153801.51470.EB

[10]   Eitel, I., Lücke, C., Behrendt, F., et al. (2010) Full recovery of Takotsubo cardiomyopathy (apical ballooning) in two days. International Journal of Cardiology, 143, e51- e53. doi:10.1016/j.ijcard.2008.12.044