In search of synthetic chemotherapeutic
substances capable of inhibiting, retarding, or reversing the process of
multi-stage carcinogenesis, we synthesized a series of novel 5-amino pyrazole
derivatives 11(a-h) by a nucleophilic substitution reaction and characterized
by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry
(LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. These novel
compounds were evaluated for their efficacy in inhibiting Ehrlich ascites tumor
[EAT] cells in-vivo. In the present study we designed, synthesized,characterized and
investigate the anti-angiogenic effects of these compounds, on Ehrlich ascites
tumor [EAT] cells in-vivo. The compounds were subsequently tested for their
ability to inhibit neovascularisation in chorio allantoin membrane (CAM) model.
From the Structure Activity Relationship (SAR) studies, it reveals that, the
substitution at N-terminal in pyrazole ring plays key role in the antitumor and
Cite this paper
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