ABSTRACT Escin is a natural mixture of triterpenoid as- ponin isolated from the seed of the horse chestnut and demonstrates anti-oedematous and anti-inflammatory effects. As yet, the pre-cise mechanisms by which escin exerts its anti- inflammatory effects remain unclear. The data from current studies indicate that the anti-in-flammatory properties of escin were attributed to its ability to reduce the adhesiveness of neu-trophils and the associated release of inflam-matory mediators; its ability to decrease hista-minic and serotoninergic activities; its ability to inhibit phospholipase A2; its ability to decrease nuclear factor-κ B activation and down-regulate the expression of tumor necrosis factor-α. All these effects are similar to glucocorticoids. Mo- reover, escin depends on adrenal glands to ex-ert its anti-inflammatory effects. Also, our recent research showed that the serum corticosterone level in mice did not increase after a 7-day in-travenous injection of escin. The results sup-port the hypothesis that escin may exert a syn-ergistic anti-inflammatory effect with glucocor-ticoids. Confirming this hypothesis will play a role in elucidating the anti-inflammatory mech- anisms of escin.
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nullZhang, L. , Wang, T. , Fan, H. , Yu, X. , Han, B. , Zhu, M. and Fu, F. (2010) Escin may exert a synergistic anti-inflammatory effect with glucocorticoids. Health, 2, 79-81. doi: 10.4236/health.2010.22013.
 Sirtori, C.R. (2001) Aescin: pharmacology, pharmacoki-netics and therapeutic profile. Pharmacol Res, 44(3), 183-93.
Guillaume, M., Padioleau, F. (1994) Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittelforschung, 44(1), 25-35.
Fu, F., Hou, Y., Jiang, W., Wang, R., Liu, K. (2005) Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World J Surg, 29(12), 1614-20.
Hu, X.M., Zhang, Y., Zeng, F.D. (2004) Effects of so-dium-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery oc-clusion in rats. Acta Pharmacol Sin, 25(7), 869-75.
Matsuda, H., Li, Y., Murakami, T., Ninomiya, K., Yama-hara, J., Yoshikawa, M. (1997) Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hip-pocastanum L., on acute inflammation in animals. Biol Pharm Bull, 20(10), 1092-5.
Arnould, T., Janssens, D., Michiels, C., Remacle, J. (1996) Effect of aescine on hypoxia-induced activation of human endothelial cells. Eur J Pharmacol, 315(2), 227-33.
Longiave, D., Omini, C., Nicosia, S., Berti, F. (1978) The mode of action of aescin on isolated veins: relationship with PGF2 alpha. Pharmacol Res Commun, 10(2), 145-52.
Xiao, G.M., Wei, J. (2005) Effects of β-Aescin on the expression of nuclear factor-kappa B and tumor necrosis factor-alpha after traumatic brain injury in rats. J Zheji-ang Univ SCI B, 6(1), 28-32.
Auphan, N., Di-Donato J.A., Rosette, C., Helmberg, A., Karin, M. (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science, 270(5234), 232-3.
Hoeck, W.G., Ramesha, C.S., Chang, D.J., Fan, N., Heller, R.A. (1993) Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. Proc Natl Acad Sci USA, 90(10), 4475-9.
Cronstein, B.N., Kimmel, S.C., Levin, R.I., Martiniuk, F., Weissmann, G. (1992) A mechanism for the antiinflam-matory effects of corticosteroids: the glucocorticoid re-ceptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion mole-cule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA, 89(21), 9991-5.
Hiai, S., Yokoyama, H., Oura, H. (1981) Effect of escin on adrenocorticotropin and corticosterone levels in rat plasma. Chem Pharm Bull, 29(2), 490-4.
 Zhang, L., Fu, F., Wang, T., Zhu, M. (2009) No up-regu-lation effects of escin on corticosterone in mice were ob-served. Basic Clin Pharmacol Toxicol, 105(Suppl. 1), 143-3.
 Wang, T., Fu, F., Zhang, L., Han, B., Zhu, M., Zhang, X. (2009) Effects of escin on acute inflammation and the immune system in mice. Pharmacol Rep, 61(4), 487-494.
 Rhen, T., Cidlowski, J.A. (2005) Antiinflammatory ac-tion of glucocorticoids—new mechanisms for old drugs. N Engl J Med, 353(16), 1711-23.
 Matsuda, H., Li, Y., Yoshikawa, M. (1999) Gastroprotec-tions of escins Ia, Ib, IIa, and IIb on ethanol-induced gas-tric mucosal lesions in rats. Eur J Pharmacol, 373(1), 63-70.