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 YM  Vol.6 No.2 , June 2022
Meta-Analysis of Aspirin for Primary Prevention of Stroke
Abstract: Objective: This paper aims to evaluate the safety and efficacy of aspirin in primary stroke prevention by meta-analysis. Methods: By searching PubMed, Cochrane Library, Embase, MEDLINE, Web of Science, CNKI, China Biomedical Literature Database, VIP Database and Wanfang Database, we collected randomized controlled trials on aspirin for primary prevention of stroke. The retrieval time limit is from the establishment of the database to December 2021. Two researchers independently conducted literature search, screening, data extraction and quality evaluation, and Meta-analysis was performed using RevMan 5.3. Results: A total of 19 articles were included, including 220,636 subjects. Meta-analysis results show that long-term preventive use of aspirin can reduce the incidence of stroke [RR = 0.91, 95% CI (0.85, 0.98), P = 0.009], and reduce the incidence of ischemic stroke [RR = 0.84, 95% CI] (0.77, 0.91), P < 0.0001], reduce the incidence of TIA [RR = 0.80, 95% CI (0.72, 0.88), P < 0.0001], reduce the incidence of myocardial infarction [RR = 0.85, 95% CI (0.75, 0.97), P < 0.01], but increased the incidence of hemorrhagic stroke [RR = 1.23, 95% CI (1.04, 1.46), P = 0.01] and gastrointestinal bleeding [RR = 1.62, 95% CI (1.35, 1.93), P < 0.01], no significant effect on mortality [RR = 0.97, 95% CI (0.93, 1.02), P = 0.20]. Conclusion: Long-term prophylactic use of aspirin can reduce the overall incidence of stroke, but there is also a risk of bleeding. The advantages and disadvantages of aspirin should be fully evaluated and strict screening should be carried out before medication, which can minimize adverse reactions and improve the safety and effectiveness of aspirin in the primary prevention of stroke.
Cite this paper: Zheng, P. , Mao, Y. , Yan, X. , Ding, J. and Ou, Y. (2022) Meta-Analysis of Aspirin for Primary Prevention of Stroke. Yangtze Medicine, 6, 41-55. doi: 10.4236/ym.2022.62004.
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