JBiSE  Vol.15 No.5 , May 2022
EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments
Abstract: In this paper, we follow up with our preliminary biological studies that showed that Repeated electromagnetic field stimulation (REMFS) decreased the toxic amyloid-beta (Aβ) levels, which is considered to be the cause of Alzheimer’s disease (AD). The REMFS parameters of these exposures were a frequency of 64 MHz and a Specific absorption rate (SAR) of 0.4 to 0.9 W/Kg in primary human neuronal cultures. In this work, an electromagnetic field (EMF) model was simulated using high-frequency simulation system (HFSS/EMPro) software. Our goal was to achieve the EM parameters (EMF Frequency and SAR) required to decrease the toxic Aβ levels in our biological studies in a simulated human head. The simulations performed here will potentially lead to the successful development of an exposure system to treat Alzheimer’s disease patients. A popular VFH (very high frequency) patch microstrip antenna system was considered in the study. The selection was based on simple and easy construction and appropriateness to the VHF applications. The evaluation of the SAR and temperature distribution on the various head layers, including skin, fat, dura, the cerebrospinal (CSF), and grey matter, brain tissues, were determined for efficacy SAR and safety temperature increase on a simulated human head. Based on a current pulse of 1 A peak current fed to the antenna feeder, a maximum SAR of 0.6 W/Kg was achieved. A range of 0.4 to 0.6 SAR was observed over the various layers of the simulated human head. The initial design of the antenna indicated an antenna size in the order of 1 m in length and width, suggesting a stationary practical model for AD therapy. Future direction is given for wearable antenna and exposure system, featuring high efficiency and patient comfort.
Cite this paper: Perez, F. , Rahmani, M. , Emberson, J. , Weber, M. , Morisaki, J. , Amran, F. , Bakri, S. , Halim, A. , Dsouza, A. , Yusuff, N. , Farhan, A. , Maulucci, J. and Rizkalla, M. (2022) EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments. Journal of Biomedical Science and Engineering, 15, 129-139. doi: 10.4236/jbise.2022.155013.

[1]   Grabher, B.J. (2018) Effects of Alzheimer Disease on Patients and Their Family. Journal of Nuclear Medicine Technology, 46, 335-340.

[2]   Sideman, A.B., Al-Rousan, T., Tsoy, E., Escudero, S.D.P., Pintado-Caipa, M., Kanjanapong, S., Mbakile-Mahlanza, L., de Oliveira, M.O., De la Cruz-Puebla, M. and Zygouris, S. (2022) Facilitators and Barriers to Dementia Assessment and Diagnosis: Perspectives from Dementia Experts within a Global Health Context. Frontiers in Neurology, 13, Article ID: 769360.

[3]   Mendiola-Precoma, J., Berumen, L., Padilla, K. and Garcia-Alcocer, G. (2016) Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research international, 2016, Article ID: 2589276.

[4]   Cummings, J. (2021) New Approaches to Symptomatic Treatments for Alzheimer’s Disease. Molecular Neurodegeneration, 16, 1-13.

[5]   Dement, A. (2016) Alzheimer’s Disease Facts and Figures, Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 12, 459-509.

[6]   Kim, T.D., Hong, G., Kim, J. and Yoon, S. (2019) Cognitive Enhancement in Neurological and Psychiatric Disorders Using Transcranial Magnetic Stimulation (TMS): A Review of Modalities, Potential Mechanisms and Future Implications. Experimental Neurobiology, 28, 1-16.

[7]   Pistollato, F., Ohayon, E.L., Lam, A., Langley, G.R., Novak, T.J., Pamies, D., Perry, G., Trushina, E., Williams, R.S. and Roher, A.E. (2016) Alzheimer Disease Research in the 21st Century: Past and Current Failures, New Perspectives and Funding Priorities. Oncotarget, 7, 38999-39016.

[8]   Weiler, M., Stieger, K.C., Long, J.M. and Rapp, P.R. (2020) Transcranial Magnetic Stimulation in Alzheimer’s Disease: Are We Ready? eNeuro, 7, 1-11.

[9]   Weiler, M., Moreno-Castilla, P., Starnes, H.M., Melendez, E.L., Stieger, K.C., Long, J.M. and Rapp, P.R. (2021) Effects of Repetitive Transcranial Magnetic Stimulation in Aged Rats Depend on Pre-Treatment Cognitive Status: Toward Individualized Intervention for Successful Cognitive Aging. Brain Stimulation, 14, 1219-1225.

[10]   Ibrahim, M.M. and Gabr, M.T. (2019) Multitarget Therapeutic Strategies for Alzheimer’s Disease. Neural Regeneration Research, 14, 437-440.

[11]   Perez, F.P., Rizkalla, J., Jeffers, M., Salama, P., Chumbiauca, C.N.P. and Rizkalla, M. (2019) The Effect of Repeated Electromagnetic Fields Stimulation in Biological Systems. In: Ionizing and Non-Ionizing Radiation, IntechOpen, London, 1-18.

[12]   Collins, C.M., Liu, W., Wang, J., Gruetter, R., Vaughan, J.T., Ugurbil, K. and Smith, M.B. (2004) Temperature and SAR Calculations for a Human Head within Volume and Surface Coils at 64 and 300 MHz. Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine, 19, 650-656.

[13]   Perez, F.P., Bandeira, J.P., Morisaki, J.J., Peddinti, S.V.K., Salama, P., Rizkalla, J. and Rizkalla, M.E. (2017) Antenna Design and SAR Analysis on Human Head Phantom Simulation for Future Clinical Applications. Journal of Biomedical Science and Engineering, 10, 421-430.

[14]   Perez, F., Millholland, G., Peddinti, S.V., Thella, A.K., Rizkalla, J., Salama, P., Rizkalla, M., Morisaki, J. and Rizkalla, M.E. (2016) Electromagnetic and Thermal Simulations of Human Neurons for SAR Applications. Journal of Biomedical Science and Engineering, 9, 437-444.

[15]   Perez, F.P., Maloney, B., Chopra, N., Morisaki, J.J. and Lahiri, D.K. (2021) Repeated Electromagnetic Field Stimulation Lowers Amyloid-β Peptide Levels in Primary Human Mixed Brain Tissue Cultures. Scientific Reports, 11, Article No. 621.

[16]   Nasica-Labouze, J., Nguyen, P.H., Sterpone, F., Berthoumieu, O., Buchete, N.-V., Cote, S., De Simone, A., Doig, A.J., Faller, P. and Garcia, A. (2015) Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies. Chemical Reviews, 115, 3518-3563.

[17]   Lak, A. and Oraizi, H. (2013) Evaluation of SAR Distribution in Six-Layer Human Head Model. International Journal of Antennas and Propagation, 2013, Article ID: 580872.

[18]   Darsono, M. and Wijaya, A. (2020) Design and Simulation of a Rectangular Patch Microstrip Antenna for the Frequency of 28 GHz in 5G Technology. Journal of Physics: Conference Series, 1469, Article ID: 012107.

[19]   Rahman, M.Z., Mynuddin, M. and Debnath, K.C. (2020) The Significance of Notch Width on the Performance Parameters of Inset Feed Rectangular Microstrip Patch Antenna. International Journal of Electromagnetics and Applications, 10, 7-18.

[20]   Ma, M.J. and Deng, K. (2010) The Study and Implementation of Meander-Line Antenna for an Integrated Transceiver Design.

[21]   Zubal, I.G., Harrell, C.R., Smith, E.O., Rattner, Z., Gindi, G. and Hoffer, P.B. (1994) Computerized Three-Dimensional Segmented Human Anatomy. Medical Physics, 21, 299-302.

[22]   Ali, M.F. and Ray, S. (2012) SAR Analysis Using DICOM Based Voxel Model. 2012 IEEE National Conference on Communications (NCC), Kharagpur, 3-5 February 2012, 1-5.