Appendicular peritonitis is complications of acute appendicitis characterized by the spread of the infectious process to the peritoneal cavity, thus producing generalized or localized purulent peritonitis. It can appear immediately or follow the stage of appendicular abscess .
Perforation is the rupture of the wall of the appendix putting its septic contents in communication with the peritoneal cavity .
Peritonitis is a medical-surgical emergency because the prognosis can be serious (depends on the patient’s age, his general condition and associated defects, the etiology and the delay in surgical management).
Despite effective health coverage in the West, the incidence of appendicular peritonitis does not decrease (20/100,000/year) .
Numerous studies carried out on peritonitis caused by digestive perforations     have shown the predominance of appendicular perforations.
Flum D.R. et al.  in the USA in 2001 in a retrospective study on 63,707 appendectomies, found 25.85% of peritonitis by appendicular perforation.
In Europe: Kraemer, M.  in 2003 in a prospective multicenter study in 11 surgical departments in Germany and Austria on 519 cases of appendicitis, found 17.7% of peritonitis by appendicular perforations.
In Africa: Chavda S.K.  in Kenya in 2005 in a retrospective and descriptive study of 289 patients managed for suspected appendicitis found 29.7% of cases of appendicular perforation with morbidity of 19.4% and zero mortality.
In Mali: Numerous studies have shown the predominance of appendicular perforations in digestive perforations.
Camara B.  in 2008 in a retrospective study at the CHU Gabriel Touré found 137 cases of appendicular peritonitis constituting 33.25% of acute generalized peritonitis with 15.3% of complications and a mortality rate of 0.7%.
Describe the epidemiological, therapeutic and evolutionary aspects, identify the main germs and their sensitivity to antibiotics.
This was a 12-month prospective and descriptive study from January 1, 2016 to December 31, 2016, in the general surgery department of Gabriel TOURE CHU.
All patients operated on for peritonitis whose etiology was appendicular intraoperatively.
All non-appendicular peritonitis and all patients operated outside the ward were not included in the study.
During the study period we collected 31 files of appendicular peritonitis which represented 4.36% of surgical interventions, 2.99% of hospitalizations, 19.25% of emergency surgical interventions, 52.54% of acute peritonitis generalized. The mean age of the patients was 20.42 years with extremes of 4 years and 58 years and a standard deviation of 12.99. The sex ratio was 2.44. Abdominal pain was the main reason for consultation in all of our patients. The average consultation time is 5.7 days, with extremes of 1 and 12 days. Treatment (traditional + medical) was carried out by 17 patients (54.8%). The most common physical signs are summarized in Table 1.
We performed 28 ultrasounds which demonstrated 16 times a cloudy effusion (51.6%), 5 times a thickening of the appendix (16.1%), a cloudy effusion plus a lesion of the appendix in 6 cases, i.e. 19, 4% and in one case the appendix was normal (3.2%). Of the 16 unprepared abdomen images taken, we had 6 times hydro-aeric levels (19.4%) and 10 times diffuse grayness (34.2%). Preoperatively, the diagnosis of appendicular peritonitis was made 23 times (74.2%), appendicular abscess 7 times (22.6%) and the diagnosis of occlusion once. The midline supra and subumbilical laparotomy was the most common route in 24 cases (77.4%). In 7 cases the incision at Mac Burney’s point was subsequently widened. An appendectomy plus washing and drainage were performed.
The pus collected and the operative parts were sent for anatomy pathology. The germs encountered were: Escherichiacoli5 cases (33.3%), Serratiae 1 case (6.7%) and Staphylococcus aureus 1 case (6.7%) In 8 cases (53.3%) the culture was sterile. The antibiograms performed showed 100% sensitivity of Escherichia coli, Seratiae and Staphylococcus aureus to cephalosporins and macrolides, 100% resistance to amoxicillin and to ampicillin at what percentage.
The consequences were simple in 23 cases or 74.2%, 5 cases of morbidity or 16.1% (4 superficial wall suppurations, and one digestive fistula), and 3 cases of death or 9.7%.
The frequency of appendicular peritonitis was 19.25% in our study. It does not differ statistically from that found in the African series by Chavda  in Kenya, Koumaré  in Mali and Flum  in the USA, Marudanayaagam , despite the delay in consultation and insufficient health coverage (Table 2). Our consultation time of 5.7 days does not differ from that observed in the African series
Table 1. The most common physical signs.
Table 2. The rate of peritonitis according to the authors (authors too old).
Table 3. Germs according to the authors.
of Harouna in Niger  and Dembélé of Mali  which was on average between 4.5 and 7 days against one day in the series. Faniez French  with a p = 0.038. This statistically significant difference could be explained by the practice of self-medication and the traditional treatments received before admission. We found germs at different rates depending on the study. These are the germs known in surgery (Table 3). The two cases of sterile pus could correspond to perforations following a parasitic appendicitis, since we did not look for these germs. Although rare, some authors have described bilharzian appendicitis in South Saharan Africa .
The therapeutic management was resuscitation for 1 to 2 hours before the operation and continued postoperatively. It was based on electrolyte rebalancing plus a triple antibiotic therapy combining a betalactamine, an aminoglycoside and an imidazole. We had to modify this treatment depending on the results of the antibiogram and the clinical course. Most of the germs isolated in our department were sensitive to these molecules. Median laparotomy was the most common route performed in 91.3% of cases as in other studies  .
The mesocoeliac position, which is not reported by many authors, was found in 7.4% of cases. This position was responsible for the occlusive forms in our study. This is confirmed in the literature . The preferred area for perforation was the top (distal part) of the appendix in 125 cases, i.e. 91.24% against 4 times (2.92%) the middle part and twice (1.46%) at the level from the base. We observed 6 cases of appendicular necrosis, i.e. 4.38%. Harouna in Niger  reported 4%. So the question arises, if the perforation has no other causes than the vascularization.
All the authors are unanimous on the eradication of the infectious focus, the fight against infection and the assurance of fluid and electrolyte balance  .
The operative technique was based on appendectomy, toilet and peritoneal drainage. This drainage is questionable for certain European authors  . The consequences were simple in the majority of cases, but we had 15.3% of morbidity which does not differ statistically from those of other African and European authors   . The mortality from acute peritonitis varies according to the aetiology. In the African series it varied between 0.7% and 17.9%, against 0% in Belgium . This could be explained by the elevation of the Mannheim peritonitis index score in African studies   and the low use of laparoscopic surgery.
Appendicular peritonitis is a complication of acute appendicitis. It is frequent and morbid. Mortality remains high despite advances in medicine. The introduction of laparoscopic surgery would improve morbidity in African countries.
 Flum, D.R., Morris, A., Koepsell, T. and Dellinger, E.P. (2001) Has Misdiagnosis of Appendicitis Decreased over Time? A Population-Based Analysis. JAMA, 286, 1748-1753.
 Kraemer, M., Kraemer, K., Leppert, R. and Acute Abdominal Pain Study Group. (1999) Perforating Appendicitis: Is It a Separate Disease? European Journal of Surgery, 165, 481-482.
 Dembelé, B. (2005) Acute Generalized Peritonitis in the General and Pediatric Surgery, Departments of the Gabriel Touré University Hospital in Bamako, Concerning 200 Cases. [Thesis] Medicine, No. 215, Bamako.
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