ABSTRACT The hypothesis is that induced pluripotent stem cells (iPSC) derived Schwann cells and/or macrophages can be transplanted into acellular nerve graft in repairing injured nervous system. The efficiency of iPSC seeded acellular nerve graft may mimic the autologous peripheral nerve graft.
Cite this paper
nullLi, J. , Gao, G. and Yuan, T. (2010) Induced-pluripotent stem cells seeded acellular peripheral nerve graft as “autologous nerve graft”. Journal of Biomedical Science and Engineering, 3, 83-84. doi: 10.4236/jbise.2010.31012.
 Schmidt, C.E. and Leach, J.B. (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng., 5, 293-347.
Gulati, A.K. and Cole, G.P. (1994) Immunogenicity and regenerative potential of acellular nerve allografts to repair peripheral nerve in rats and rabbits. Acta Neurochir (Wien), 126(2–4), 158-64.
Yu, J. and Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917-20.
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-72.
Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-76.