Congenital gangrene of the extremities of the newborn is a rare phenomenon in neonatology in many cases; no etiological factors are demonstrated  . The cases described focus on the mother-fetal pathologies involved and emphasize urgent surgical treatment in case of proven ischemia of a limb . Nevertheless, any neonatal gangrene suggests intrauterine etiopathogenesis; several risk factors may be related to congenital gangrene. They are mentioned: prematurity, systemic infection, maternal diabetes, dystocic presentations, hypothermia, and congenital heart disease  . Management is not codified and treatment is based on antibiotic therapy, heparinotherapy and surgical amputation     . We report a case of congenital gangrene of the collected hand in the pediatric department of the Sikasso Hospital.
2. Patient and Observation
This is a premature female newborn of (29 weeks) from a twin pregnancy poorly followed by no blood or radiological assessment performed in a 25-year-old mother with no known pathological history G4P4V3A0. The delivery took place vaginally in a community health center with G1 female weighing 1030 g Apgar unspecified and G2 male weighing 1010 g stillborn. Addressed to our service for respiratory distress and cyanosis of the left hand. From birth, the newborn presented a phlyctene that was aggravated 48 hours later by a total cyanosis of the left hand, hence the decision to transfer it to our training for further management. Clinical examination at admission found a newborn that was unstable on planes: hemodynamic, neurological and respiratory, weighing 980 g, Size = 34 cm, PC = 24 cm, Temperature 35.1˚C with saturation at 95%. Presence of necrosis of the hand and left forearm well limited, with absent humeral pulse and absence of movement of the hand (Figure 1). The biological assessment showed an infectious syndrome, anemia at 7 g/dl with a prothrombin level (TP) at 60% and a normal activated cephalin time (TCA). The newborn was put on triple antibiotic therapy, blood transfusion, caffeine citrate, hydroelectrolytic infusion with local care. Surgical treatment was scheduled for amputation of the limb after the agreement of the parents whose postoperative follow-ups were simple (Figure 2). The newborn was discharged to a hospitalized J20 with a weight at 1045 g and a weight gain at 15 g/kg/day and scarring (Figure 3). The infant was followed in the kangaroo mother program and had a good prognosis. The newborn was referred to the orthoprosthetist center for equipment.
Figure 1. Necrosis of the left hand.
Figure 2. Amputated hand.
Figure 3. Wound healing.
Gangrene of the extremities in newborns is extremely rare   . The first description is attributed to Martini (1828) quoted by Blank et al.  . Acute ischemia of the limbs is most often caused by thromboembolic phenomena     . Several risk factors such as gestational diabetes, prematurity, congenital heart disease, obstetric trauma, polycythemia, sepsis etc. have been cited in the literature as predisposition factors for congenital gangrene of the extremities     . According to some authors, its cause is not identified in most cases.    . However, other authors find that arterial insufficiency can lead to limb ischemia either by intrauterine compression or by arterial thrombosis  . The management of these newborns has two components: the first is medical treatment based on antibiotic therapy, whether or not combined with heparinotherapy. The second is surgical but given the major psychosocial impact for the patient and his family as well as the tissue regeneration power of the newborn   . There is a trend towards procrastination by not proceeding to amputation from the outset pending a definitive demarcation of the gangrene part but in the case of established gangrene, amputation is the treatment of choice. Nevertheless, by reviewing the literature, it was found that almost all reported cases proceeded to urgent amputation   . On the other hand, timothy and cervix reported a case of thrombectomy performed at H10 of life in a newborn with necrosis of the hand . Thus Ufuk Aydin and cervix successfully treated a case of congenital gangrene of the upper limb through negative pressure therapy . Our attitude was in accordance with the algorithm for the management of acute limb ischemia lesions of children under three years of age proposed by Geordiadis et al.  which states that in case of irreversible gangrene it is necessary to amputate.
Congenital gangrene remains a rare entity in neonatology; only a dozen cases have been reported by the literature. The pathophysiology of these cases of congenital gangrene remains poorly established, as does the etiology. Therapeutic management is the subject of controversy between those who advocate amputation from the outset and those who lean more towards conservative treatment at first.
Informed consent from the parents was obtained for the publication.
Contributions by Authors
All the authors contributed to the realization of this work. All of them read and approved the final version of the manuscript.
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