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 AJMB  Vol.11 No.3 , July 2021
Joint Effects of Mexidol and Nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues
Abstract: This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units; produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.
Cite this paper: Zhumabaeva, T. , Kuropteva, Z. , Moldaliev, Z. , Zhumabaeva, N. , Kadyrbaeva, A. , Bopoev, N. and Abdullaeva, Z. (2021) Joint Effects of Mexidol and Nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues. American Journal of Molecular Biology, 11, 73-82. doi: 10.4236/ajmb.2021.113007.
References

[1]   Deviatkina, T.A., Lutsenko, R.V. and Vazhnichaia, E.M. (2003) Pharmacological Activity of Mexidol in the Stress-Induced Liver Damage. Eksperimental’naia i klinicheskaia farmakologiia, 66, 56-58.

[2]   Katikova, O. (2002) Effect of Mexidol on the Homeostasis and Lipid Peroxidation in Paracetamol Poisoning. Eksperimental’naia i klinicheskaia farmakologiia, 65, 53-56.

[3]   Agvald, P., Adding, L.C., Artlich, A., Persson, M.G. and Gustafsson, L.E. (2002) Mechanisms of Nitric Oxide Generation from Nitroglycerin and Endogenous Sources during Hypoxia in Vivo. British Journal of Pharmacology, 135, 373-382.
https://doi.org/10.1038/sj.bjp.0704489

[4]   Furchgott, R. and Zawadzki, J. (1980) The Obligatory Role of Endothelial Cells in the Relaxation of Arterial Smooth Muscle by Acetylcholine. Nature, 288, 373-376.
https://doi.org/10.1038/288373a0

[5]   Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E. and Chaudhuri, G. (1987) Endothelium-Derived Relaxing Factor Produced and Released from Artery and Vein Is Nitric Oxide. Proceedings of the National Academy of Sciences of the United States of America, 84, 9265-9269.
https://doi.org/10.1073/pnas.84.24.9265

[6]   Ignarro, L.J. (1990) Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide. Annual Review of Pharmacology and Toxicology, 30, 535-560.
https://doi.org/10.1146/annurev.pa.30.040190.002535

[7]   Ignarro, L.J. (1990) Nitric Oxide. A Novel Signal Transduction Mechanism for Transcellular Communication. Hypertension, 16, 477-483.
https://doi.org/10.1161/01.HYP.16.5.477

[8]   Davies, S.A., Stewart, E.J., Huesmann, G.R., Skaer, N.J., Maddrell, S.H., Tublitz, N.J. and Dow, J.A. (1997) Neuropeptide Stimulation of the Nitric Oxide Signaling Pathway in Drosophila melanogaster Malpighian Tubules. The American Journal of Physiology, 273, R823-R827.
https://doi.org/10.1152/ajpregu.1997.273.2.R823

[9]   Nathan, C.F. (1983) Mechanisms of Macrophage Antimicrobial Activity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 77, 620-630.
https://doi.org/10.1016/0035-9203(83)90190-6

[10]   Palmieri, E.M., McGinity, C., Wink, D.A. and McVicar, D.W. (2020) Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight. Metabolites, 10, 429.
https://doi.org/10.3390/metabo10110429

[11]   Xue, Q., Yan, Y., Zhang, R. and Xiong, H. (2018) Regulation of iNOS on Immune Cells and Its Role in Diseases. International Journal of Molecular Sciences, 19, 3805.
https://doi.org/10.3390/ijms19123805

[12]   Mahmoud, M.F., Zakaria, S. and Fahmy, A. (2015) Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats? Advances in Pharmacological and Pharmaceutical Sciences, 2015, Article ID: 298792.
https://doi.org/10.1155/2015/298792

[13]   Belaya, O.L., Baider, L.M. and Kuropteva, Z.V. (2006) Effect of Mexidol and Nitroglycerine on Iron-Sulfur Centers, Cytochrome P-450, and Nitric Oxide Formation in Liver Tissue of Experimental Animals. Bulletin of Experimental Biology and Medicine, 142, 422-424.
https://doi.org/10.1007/s10517-006-0382-y

[14]   Lushchak, O.V., Piroddi, M., Galli, F. and Lushchak, V.I. (2014) Aconitase Post-Translational Modification as a Key in Linkage between Krebs Cycle, Iron Homeostasis, Redox Signaling, and Metabolism of Reactive Oxygen Species. Redox Report, 19, 8-15.
https://doi.org/10.1179/1351000213Y.0000000073

[15]   Kuropteva, Z.V. (1985) Changes in the Paramagnetic Complexes of Blood and Liver of Animals under the Influence of Nitroglycerin. Reports of the Academy of Sciences of the USSR, 281, 189-192.

[16]   Zhumabayeva, T.Z. and Kuropteva, V. (1986) Molecular Mechanisms of the Radiosensitizing Action of Nitro Compounds. Radiobiology, 26, 671-674.

[17]   Belaya, O.L., Fomina, I.G., Bider, L.M. and Kuropteva, Z.V. (2006) Iron Sulfur Centers, cit P-450 and the Formation of Nitric Oxide in Liver Tissues of Animals under the Action of Mexidol and Nitroglycerin. Bulletin of Experimental Biology and Medicine, 142, 403-406.
https://doi.org/10.1007/s10517-006-0382-y

[18]   Palmer, R.M., Ferrige, A.G. and Moncada, S. (1987) Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor. Nature, 327, 524-526.
https://doi.org/10.1038/327524a0

 
 
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