Hepatic tuberculosis is rare and constitutes less than 1% of all tuberculosis sites. It can take different aspects. It currently benefits from the contribution of diagnostic techniques of molecular biology that allow a diagnosis fast on liver biopsy slides. The positive diagnosis is confirmed by the detection of Koch’s bacillus on direct examination, culture and amplification by PCR techniques of granulomas associated with caseous necrosis in the biopsy fragments.
Treatment of primary hepatic tuberculosis is 6 months including 2 months of triple therapy and 4 months of dual therapy .
2. Case Report
A 30 years old female was admitted to our hospital; without medical or surgical history or associated defects, she had an average socio-economic level. She had no history of tuberculosis or contact with a patient with tuberculosis. The beginning of the history of his illness dates back to 01 months before his hospitalization by the appearance of parietal swelling basi-thoracic right; associated with gravitational pain in the right hypochondrium. Without digestive or respiratory symptoms (no cough, hemoptysis) nor night sweats, all evolving in a context of apyrexia and conservation of the general state.
The clinical examination found a patient in good general condition, apyretic, normotensive, with normal colored conjunctives.
The inspection objectified a swelling next to the 10th and 12th right ribs. Palpation revealed a sensitive hepatomegaly. The ganglionic areas were free. The rest of the somatic examination was peculiar.
The biological assessment was normal. The serological test was negative.
The chest x-ray did not show any obvious lesion. Abdominal computed tomography (Figure 1) showed a cystic lesion of the liver coming into contact with the right lateral thoracic wall,
The decision of a surgical procedure was made: the radiological aspect which was in favor of a hydatid cyst of the liver. A subcostal costal was performed with firstly protection of the operative field by fields soaked with a scolicide solution. Then the puncture of the cyst and aspiration of about 2 liters of purulent fluid, then injection of oxygenated water with cleaning and total aspiration of the liquid, then we performed a resection in dome protruding from the cyst with drainage of the residual cavity after careful inspection of the cavity for any biliary leaks. The liquid is sent for bacteriological examination and histological study of the cystic wall. The bacteriological examination was negative. Histological study of the cyst wall revealed tuberculoid granulomatous inflammations with caseous necrosis.
So the diagnosis of hepatic tuberculosis was retained and anti-bacillary treatment was started for 9 months.
The patient has evolved favorably under medical treatment and Control ultrasound showed complete resolution of liver abscess and swelling (Figure 2).
Clinical, biological and radiological control for one year after the end of treatement and disappearance of the radiological images was normal.
Figure 1. A computed tomography scan (CT) revealed a large cystic liver lesion interesting the right liver extending to involve right lateral chest wall forming a collection in an intermuscular.
Figure 2. Ultrasound showed complete resolution of liver abscess.
The average age of patients with hepatic tuberculosis was 30 years with extremes ranging from 17 - 50 years . No difference in frequency in both sexes   , although in a series of cases (14 cases of hepatic tuberculosis collected in the gastroenterology department of Ibn Rochd Hospital, Casablanca between January 1990 and January 2001) they noted a clear female predominance with 12 women for 2 men, a sex ratio of 0.16 . There is a higher incidence of hepatic tuberculosis in the black race   .
A digestive localization is present in 5% to 30% of the cases of tuberculosis occurring in the subjects infected with the HIV . These are hepatic forms in more than 50% of cases compared to 15% in the uninfected population. Digestive localizations are very rare when the number of lymphocytes is greater than 250/mm3. However, when this rate is less than 100/mm3, liver damage is more common in the form of a miliary.
Localized involvement is extremely rare in HIV-infected individuals: 9 cases of hepatic abscess have been reported in the literature .
Unlike secondary involvement, primary hepatic tuberculosis is rare. Its frequency with regard to tuberculosis digestive sites is 0.5% and 1.2%  .
The clinical approach to hepatic tuberculosis is always very delicate because hepatic tuberculosis is considered a clinically silent disease or in symptomatic forms the picture is non-specific or even misleading .
TLA is usually confused with hepatoma, pyogenic or amoebic liver abscess and is often diagnosed at autopsy or after laprotomy because of its non specific presentation .
The fever can take different aspects: moderate or very high; it is frequent but not constant, and persists  in the absence of a specific treatment. Fever was reported in 65% of cases by Alvarez , and 66%, 90% and 63% respectively by Essop, Hersh and Maharaj according to the Alvarez metanalysis. Abdominal pain was the most common reason for consulting; it was reported by Alvarez (45%) , Essop (66%), Hersh (50%) and Maharaj (46%). In our case the pain was found; it was localized at the level of the right hypochondrium. Asthma, anorexia, weight loss and night sweats  are signs often found in patients with hepatic tuberculosis, Hepatomegaly can be painful or painless. The pain is awakened by palpation, sometimes even spontaneously, firm , Hepatomegaly was present in 96% of cases in the series of Alvarez : nodular simulating liver cancer in 55% of cases and closes in 36%.
Portal hypertension and jaundice are rare or even exceptional, the jaundice is often related to compression of the extrahepatic biliary tract  (Table 1).
The contribution of biological examinations in the positive diagnosis of hepatic tuberculosis is very limited. Sedimentation velocity is almost constantly accelerated, but variably . C-reactive protein and fibrinogen can also be elevated . Moderate normocytic anemia can be seen. Pancytopenia can be found in the context of hypersplenism or associated medullary involvement. Apart from the elevation of alkaline phosphatase, liver function remains normal. Serum alkaline phosphatase activity is increased to 1.5 to 5 times the upper limit of normal in 50% to 75% . Tuberculin reactions are often positive or phlyctenular ; but their negativity can in no way constitute an argument against the diagnosis of this affection.
Abdominal ultrasonography scan usually reaveled hypoechoic lesions in most cases of TB liver abscess . However, a hyperechoic lesion was reported in
Table 1. Clinical signs in different studies.
one case . CT scan usually demonstrates a low-attenuation lesion with or without ring enhancement .
Thus, the specificity of ultrasonography and CT is low in detecting TLA but in defining the site, size and the nature of the abscess, their value is indispensable .
It is difficult to make the diagnosis of hepatic tuberculosis clinical, biological and radiological data, hence the need for histological confirmation, although in a number of cases, histological lesions may be found in other pathologies that raise the problem of the etiological diagnosis of hepatic granulomatosis.
The hepatic fragment can be obtained either by a biopsy puncture Transvarietal liver, either by laparoscopic biopsy or during exploratory laparotomy.
The detection of tubercle bacilli by culture is positive in only 10% and 35% of cases .
Molecular biology techniques by DNA amplification of BK are not part of routine examinations. They allow to obtain in 48 hours the diagnosis  . Recently, Alcantra et al.  have developed the use of PCR for the identification of BK in the biopsy fragment. He reported 100% success in cases where there is caseous necrosis against 78% in front of a granuloma or other suspicious lesion of tuberculosis.
Caseous necrosis test is positive in 67% of cases for Alvarez et al., in 83% for Essop et al., in 51% for Maharaj et al.  . Even caseous necrosis does not represent tuberculosis exclusively , the treatment outcome of anti-tuberculous regimen confirms the diagnosis indirectly. The lack of a positive tuberculosiss culture and PCR results did not influence the final diagnosis, especially in a country with high burden of tuberculosis .
Management of TLA includes anti tubercular therapy for one year alone or in combination with percutaneous drainage . Surgical management is usually reserved for cases of multiple unsuccessful attempts of percutaneous aspiration, inaccessible site, and multiseptate nature of the abscess .
Hepatic tuberculosis represents −1% of all cases of tuberculosis. Most of these cases are immunocompromised individuals infected with HIV. It is most often a form secondary to another tuberculous focus, more rarely a primitive form. This location raises a number of difficult diagnostic problems because of its clinical expression; biological; radiological, and histological polymorphous and evocative, hence the importance of always thinking about this diagnosis in front of any granulomatous or pseudo-tumoral liver disease especially in a country of endemic tuberculosis and on an immunocompromised field.
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