Back
 IJCM  Vol.12 No.2 , February 2021
Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery
Wei Chen1,2,3*, Junwen Ye1,2,3*, Xiaoping Tan4*, Yan Zhang2,3,5, Jinglin Liang1,2,3#, Meijin Huang1,2,3#
Abstract: Objective: The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. Methods: 154 T4 colorectal cancer patients who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University were included in the study between August, 1994 and December, 2005. Some clinical variables were selected and statistically correlated with prognosis. Results: The overall survival time was 91.7 months at the end of December of 2010 or death. The complete cytoreduction had significant survival benefit than the palliative surgery group. The age, location, histological grade, complete cytoreduction and liver metastasis were associated with overall survival time (OS) according to the univariate analysis (P < 0.05). In addition, Cox multivariate analysis showed that the complete cytoreduction (CCR) and liver metastasis were independent factor influencing survival. Conclusion: Compared with palliative surgery, the incomplete cytoreduction fails to improve patient prognosis. Patients performed completed cytoreduction have a relative good prognosis.
Cite this paper: Chen, W. , Ye, J. , Tan, X. , Zhang, Y. , Liang, J. and Huang, M. (2021) Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery. International Journal of Clinical Medicine, 12, 61-70. doi: 10.4236/ijcm.2021.122008.
References

[1]   Brenner, H., Kloor, M. and Pox, C.P. (2014) Colorectal Cancer. Lancet, 383, 1490-1502.
https://doi.org/10.1016/S0140-6736(13)61649-9

[2]   Gebhardt, C., Meyer, W., Ruckriegel, S. and Meier, U. (1999) Multivisceral Resection of Advanced Colorectal Carcinoma. Langenbeck’s Archives of Surgery, 384, 194-199.
https://doi.org/10.1007/s004230050191

[3]   Jayne, D.G., Fook, S., Loi, C. and Seow-Choen, F. (2002) Peritoneal Carcinomatosis from Colorectal Cancer. British Journal of Surgery, 89, 1545-1550.
https://doi.org/10.1046/j.1365-2168.2002.02274.x

[4]   Santvoort, H.C.V., Braam, H.J., Spekreijse, K.R., Koning, N.R., de Bruin, P.C., de Vries Reilingh, T.S., et al. (2014) Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors. Annals of Surgical Oncology, 21, 1686-1691.
https://doi.org/10.1245/s10434-013-3461-0

[5]   Koppe, M.J., Boerman, O.C., Oyen, W.J. and Bleichrodt, R.P. (2006) Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies. Annals of Surgery, 243, 212-222.
https://doi.org/10.1097/01.sla.0000197702.46394.16

[6]   Takeshita, K., Liu, Y., Ishibashi, H. and Yonemura, Y. (2017) Laparoscopic Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Gastric Cancer: Its Beneficial Effects on Reduction and Exact Evaluation of the Peritoneal Cancer Index. American Surgeon, 83, 1315-1320.
https://doi.org/10.1177/000313481708301138

[7]   Lukas, R.V., Mata-Machado, N.A., Nicholas, M.K., Salgia, R., Antic, T. and Villaflor, V.M. (2016) Leptomeningeal Carcinomatosis in Esophageal Cancer: A Case Series and Systematic Review of the Literature. Diseases of the Esophagus, 28, 772-781.
https://doi.org/10.1111/dote.12276

[8]   Delhorme, J.B., Dupontkazma, L., Addeo, P., Lefebvre, F., Triki, E., Romain, B., et al. (2016) Peritoneal Carcinomatosis with Synchronous Liver Metastases from Colorectal Cancer: Who Will Benefit from Complete Cytoreductive Surgery? International Journal of Surgery, 25, 98-105.
https://doi.org/10.1016/j.ijsu.2015.11.025

[9]   Gu, F.M., Chi, F.L., Dai, C.F., Chen, B. and Li, H.W. (2013) Surgical Outcomes of 43 Cases with Adenoid Cystic Carcinoma of the External Auditory Canal. American Journal of Otolaryngology, 34, 394-398.
https://doi.org/10.1016/j.amjoto.2013.01.018

[10]   Kelder, W., Inberg, B., Schaapveld, M., Karrenbeld, A., Grond, J., Wiggers, T. and Plukker, J.T. (2009) Impact of the Number of Histologically Examined Lymph Nodes on Prognosis in Colon Cancer: A Population-Based Study in the Netherlands. Diseases of the Colon & Rectum, 52, 260-267.
https://doi.org/10.1007/DCR.0b013e3181979164

[11]   Maggiori, L., Goéré, D., Viana, B., Tzanis, D., Dumont, F., Honoré, C., et al. (2013) Should Patients with Peritoneal Carcinomatosis of Colorectal Origin with Synchronous Liver Metastases Be Treated with a Curative Intent? A Case-Control Study. Annals of Surgery, 258, 116-121.
https://doi.org/10.1097/SLA.0b013e3182778089

[12]   Verwaal, V.J., Ruth, S.V., de Bree, E., van Slooten, G.W., van Tinteren, H., et al. (2003) Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer. Journal of Clinical Oncology, 21, 3737-3743.
https://doi.org/10.1200/JCO.2003.04.187

[13]   Gulack, B.C., Nussbaum, D.P., Keenan, J.E., Ganapathi, A.M., Sun, Z.F., Worni, M., et al. (2016) Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer without Metastasectomy is Associated with Improved Overall Survival Compared to Chemotherapy/Radiation Therapy Alone. Diseases of the Colon & Rectum, 59, 299-305.
https://doi.org/10.1097/DCR.0000000000000546

[14]   Yun, J.A., Huh, J.W., Park, Y.A., Cho, Y.B., Yun, S.H., Kim, H.C., et al. (2014) The Role of Palliative Resection for Asymptomatic Primary Tumor in Patients with Unresectable Stage IV Colorectal Cancer. Diseases of the Colon & Rectum, 57, 1049-1058.
https://doi.org/10.1097/DCR.0000000000000193

[15]   Bajwa, A., Blunt, N., Vyas, S., Suliman, I., Bridgewater, J., Hochhauser, D., et al. (2009) Primary Tumour Resection and Survival in the Palliative Management of Metastatic Colorectal Cancer. European Journal of Surgical Oncology, 35, 164-167.
https://doi.org/10.1016/j.ejso.2008.06.005

 
 
Top