OJEpi  Vol.11 No.1 , February 2021
An Interrupted Time Series Analysis of COVID-19 Positivity before, during and after Lockdown in Four States of India
Abstract: Objectives: The objective of this study was to examine the impact of large scale non-pharmaceutical interventions on COVID-19 pandemic. Methods: We used interrupted time series analysis (ITS), a quasi-experimental model to evaluate the effect of interventions in four states of India by comparing the COVID-19 positivity before lockdown, during lockdown and opening-up period. Results: The positivity in all the four states declined during lockdown and the trends reversed soon after the lockdown measures were relaxed as the states opened-up. The rate of reduction of positivity was significantly different between states. Between the lockdown and opening-up period, an increase in positivity was recorded in all the states with significant variation between states. Conclusion: The analysis provides conclusive evidence that the lockdown measures had a positive effect in reducing the burden of COVID-19 and establishes a causal relationship.

1. Introduction

India’s first few cases of COVID-19 were detected in Kerala by the end of January 2020. The country’s strategy till March, was to screen people with a history of international travel or contact with a known case of COVID-19, quarantine/isolate and treat. With a steady increase in the number of Influenza-Like Illness (ILIs) and Severe Acute Respiratory Infection (SARI) turning positive for COVID-19, the Government of India advised the States to invoke the provisions of Section 2 of the Epidemic Diseases Act 1897, to enable imposing restrictions like school and theatre closures, and banning large gatherings [1] [2]. The first large-scale containment measure in the form of a nationwide lockdown was introduced on March 25, till May 30, 2020 and later on, a phased unlock was introduced [3].

Mathematical models have widely been used to inform policy, programme planning, and service delivery related to COVID-19 [4]. Several models predicted the spread of COVID-19 with varying levels of accuracy [5] [6] [7]. These models forecasted the number and progression of infections and predicted the health system resource requirements, with different levels of assumptions about the effect of non-pharmaceutical interventions on the epidemic. Falxman et al., 2020, assumed an immediate effect on infectious people becoming less infective; Davies et al., 2020, assumed a differential contact because of preferential self-isolation among people with clinical features; while Mandal et al., 2020, assumed the transmission dynamics in India to be similar to Japan and South Korea, considering half of the symptomatic cases to be quarantined within three days of developing symptoms [8] [9] [10]. These assumptions provided much-needed possible scenarios of epidemic forecasting, however, they did not offer conclusive evidence regarding non pharmaceutical interventions. Applying the principle of causality in measuring the effect of a policy intervention is crucial [11] [12] [13]. Our analysis examines the impact of lockdown as a policy intervention on COVID 19 positivity in four states of India.

2. Methods

2.1. Data

We obtained data on the number of tests and positive results for four states in India—Kerala, Tamil Nadu, Karnataka, and Odisha, from respective state governments’ official COVID-19 dashboard or bulletin [14] [15] [16] [17]. These four states were selected as data was available consistently since the beginning of the epidemic.

Data was collected from March 15th to the 3rd week of July 2020 for all four states. This included the pre-lockdown period, lockdown period, and post-lockdown (opening up) period. The outcome of interest was daily test “positivity” (Test Positivity Rate-TPR) which is the number of reported positive tests of the total samples tested [18] [19]. We included three phases of time periods in the analysis:

Time series 1, Pre-lockdown period: 15th March to 3rd April was included in the analysis primarily to capture the early stage situation of the epidemic before lockdown. As we relied on positive test results published in the state bulletins, it was essential to capture those who got infected during pre-lockdown but were detected afterwards. To account for time-lags between infection during pre lockdown and obtaining test results, we added 10 days, considering an incubation period of 6 days and maximum delay to obtain test results as 4 days [20] [21].

Time series 2, Lockdown period 1 and 2: 4th April to 9th May reflects the lockdown period. Though the lockdown was lifted on 3rd May, we considered 6 additional days to account for the spillover of the effect which is the difference between infection and reported test results. Six days was considered here, instead of 10 days, assuming increased efficiency of testing and reporting [22].

Time series 3, Relaxed lockdown to the Opening up period: 10th May to 19th July consisted of gradual opening up phase.

Data pertaining to 22nd March 2020 in Karnataka showed very high positivity (60%), it was considered an outlier and excluded from analysis.

2.2. Model

We examined the impact of lockdown on the Test Positivity Rate (TPR). Though Randomised control trials (RCT) are considered the “Gold Standard” for impact evaluation, the pandemic nature of COVID-19 and population-level non-pharmaceutical interventions restrict the use of RCT in the current situation. We used interrupted time series analysis (ITS), a quasi-experimental model, which has been implemented elsewhere for other diseases including COVID-19 for evaluating the effect of population-level interventions over a period of time [23] [24] [25].

2.3. Data Analysis

A preliminary analysis was done using ordinary least squares (OLS) method. Autocorrelation function (ACF) and partial autocorrelation (PACF) function were used to examine the correlation of residuals of OLS in terms of moving average and autoregressive lags through the ACF and PACF plots. The final analysis was done using generalised least square model (GLS) to fit the data and appropriate lags indicated by the ACF and PACF plots for the respective states. The trend line for each time series was extended linearly to demonstrate the counterfactuals for the next time period i.e. for time series 2 and 3. The counterfactuals were used to examine the effect of time-varying policy interventions on the causality criteria of strength, consistency, specificity, temporality, plausibility, biological gradient, coherence, analogy, experimentation, and reversibility, with respect to Covid-19 positivity. Open-source software R was used for analysis [26].

3. Results

The TPR for all the states decreased in phase 2 (lockdown) and increased in phase 3 (Opening-up), even in states which had an initially high TPR, e.g.; Tamil Nadu’s TPR was 13.1%, 4.0% and 9.6% during pre-lockdown, lockdown and opening up phase, while Karnataka’s TPR was 3.4%, 0.8% and 11.5% respectively.

Karnataka and Odisha had increasing trends in the TPR (solid blue line) during the pre-lockdown phase and predicted to increase (predicted direction is shown as broken blue line), if the lockdown had not been imposed (Figure 1 and Figure 4). The TPR decreased during phase 1 and 2 (solid red line) and would have presumably continued to decline (dashed red line, counterfactual). However, it rapidly increased during opening/post lockdown phase (solid light blue line). In contrast, the post lockdown TPR in Kerala and Tamil Nadu (Figure 2, Figure 3) increased slowly, as compared to the rapid increase in Karnataka and Odisha. During the opening up phase, the TPR showed a relatively slower increase in Tamil Nadu and Kerala and a steep increase in Odisha and Karnataka.

Other difference between the states included a steady increase in TPR in Odisha during opening up phase. Tamil Nadu’s TPR increased till the end of March followed by a decline and continued to increase from early June. Karnataka showed a steep increase of around 3% at the end of June, to 14% by the end of July. Kerala’s TPR increased to almost 12% around the last week of March and reduced thereafter (Figures 1-4).

Figure 1. COVID-19 positivity in Karnataka.

Figure 2. COVID-19 positivity in Kerala.

Figure 3. COVID-19 positivity in Tamil Nadu.

Figure 4. COVID-19 positivity in Odisha.

From pre-lockdown to lockdown period, there was a drop in TPR in all the states and the effect reversed during the unlock period except in Karnataka where the levels were lower during the relaxation of lockdown period. The lockdown resulted in statistically significant declining trends of TPR in all the states except Odisha. The declining trends reversed during opening up period, which were also statistically significant in all the states, except Kerala.

4. Discussion

Multiple non-pharmaceutical public health measures such as promotion of handwashing, usage of face masks, travel restrictions, contact tracing, isolation and treatment of cases were implemented concurrently, besides the national level lockdown. Our analysis indicated that the lockdown imposed in the country had a positive effect on the TPR of COVID-19 in all the four states. The counterfactual trends indicate that the TPR would have increased dramatically and substantiates the causal effect of a declining TPR brought by the lockdown. While the TPR increased during post lockdown and unlock period, it is evident that the lockdown had actually provided adequate time to prepare and strengthen the health systems by delaying the peak of infections, which could be the overall intent of policy makers and program planners.

The central question is the causal effect of lockdown on the pandemic and its direction. As demonstrated in Table 1, the reduction in the TPR during lockdown was statistically significant in all the states, except Odisha. During the unlock (opening up) period, the TPR increased significantly in all the states. It is essential to understand that test positivity depends on testing strategy, availability of test kits, sensitivity and specificity of test kits. As Indian Council of Medical Research (ICMR) suggested a uniform testing strategy for all states since the beginning of the epidemic, we assume the testing strategy to be consistent in the selected four states.

Before lockdown, large scale measures like international travel ban was implemented which did not fully prevent the spread of COVID-19 [27] and demonstrated the temporal relationship between lockdown and COVID-19 positivity. A few peaks in the epidemic had some reasons: For example, initial peaks in TPR in Kerala could be due to international returnees, and in Tamil Nadu, due to specific super spreader events causing isolated clusters early in the epidemic.

Table 1. Generalised least square regression results.

Essentially, the effect of lockdown is consistent with the general understanding that social distancing reduces the risk and spread of disease, as demonstrated in other disease models [28] [29].

5. Conclusion

The country-wide lockdown measures had a positive impact on COVID-19 response, indicated by reductions in daily positivity in four selected states in India. However, COVID-19 is a fluctuating and dynamic pandemic with too many varying operational and epidemiological factors that need to be considered while making interpretations. Further analysis at the district or regional level would be useful to inform local actions and undertake specific corrective measures.


This analytical work was not supported by any individual or organization and the authors did not receive any funding support for this work. The authors acknowledge the work of Prof Michael Law for sharing his codes in public domain and providing critical input.

Author Contributions

Conceptualization: ST, GRJ, AEM, BRK, LPC, Data curation: ST, AEM, BRK, LPC. Formal analysis: GRJ, AEM, LPC. Methodology: ST, GRJ, AEM, BRK, LPC. Project administration: SKP. Visualization: LPC. Writing: ST, GRJ, AEM, LPC, Writing-review & editing: ST, GRJ, AEM, BRK, LPC.

Cite this paper: Tetali, S. , Jammy, G. , Asirvatham, E. , Kumar, B. and Choudhury, L. (2021) An Interrupted Time Series Analysis of COVID-19 Positivity before, during and after Lockdown in Four States of India. Open Journal of Epidemiology, 11, 47-55. doi: 10.4236/ojepi.2021.111005.

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