Hyperhidrosis can be defined as a pathologic condition characterized by excessive sweating beyond the organism’s physiological needs to maintain the body temperature within an adequate range. Hyperhidrosis is divided into primary or secondary. Primary hyperhidrosis is the pathology itself, characterized by the excessive sweating. The etiology of primary hyperhidrosis remains unknown despite multiple literature reviews  . Genetic factors may play a role in excessive neural stimulation, although this is not well understood. It occurs in about 2% of the world population, affecting equally men and women. The primary hyperhidrosis is usually localized and mostly in palmar, axilla, and/or sole. Craniofacial hyperhidrosis can occur, alone or with facial blushing. Secondary causes are usually easier to identify because they are associated with medications such as dopamine agonists, selective serotonin release inhibitors (SSRIs), antipsychotics, alcohol, and insulin, systemic disorders such as diabetes mellitus, hyperthyroidism, Parkinson disease, and other neurologic disorder, and tumors such as pheochromocytoma and lymphoma  . A variety of clinical treatments can be tried to use in primary hyperhidrosis. These treatments are indeed less invasive than a surgical intervention, but all of them have only a palliative potential and, once stopping the therapy, the symptoms will relapse in virtually all patients. Sweat glands ablation by energy-based devices is a promising nonsurgical alternative to treat hyperhidrosis, especially for axillary cases. The approved devices use microwave energy, high-intensity focused ultrasound or laser therapy  . From a practical point of view, it means that the majority of patients will eventually end up seeking a surgical consultation. There are several ways to treat excessive sweating: antiperspirants (e.g. Aluminium Zirconium, Tetrachlorohydrex Glycine), iontophoresis, anticholinergic medication, psychotherapy, botulinum toxin injections and surgery. Recently, there is increased awareness of the use of botulinum toxin injections as a non-surgical treatment of hyperhidrosis  . Surgical treatment by open method is replaced by minimally invasive vidio assisted thoracoscopic sympathectomy. In present days, thoracoscopic sympathectomy is performed by minimally invasive video-thoracoscopy; there are no arguments to justify any open surgery to address the thoracic sympathetic trunk. The sympathetic chain runs under the parietal pleura along each side of the spine, at the level of the necks of the ribs, near the articulation between ribs and vertebrae. The chain is a whitish cord, visible and palpable in the majority of individuals. Even though excessive local fat can preclude a clear identification of the chain, the ribs are usually easy to visualize. Bilateral thoracoscopic sympathectomy is a suitable method of treatment for severe palmar hyperhidrosis but emphasizes the need to offer the patient more information, especially regarding compensatory sweating which seems inescapable  . Bilateral thoracoscopic sympathectomy and its variations have been performed in thoracic surgery for more than 100 years. However, its indications have undergone profound modifications in this period. Likewise, since then the surgical technique has also evolved dramatically up to the minimally invasive techniques worldwide accessible in present days. The main indication for thoracoscopic sympathectomy is primary hyperhidrosis. This operation has a good result and helps patients to improve their quality of life.
A prospective cohort study was made for patients who underwent bilateral thoracoscopic sympathectomy and 36 patients were admitted to the general surgical department, in Al-Kuwait University Teaching Hospital and Al-Thowra Modern University Hospital in Sana’a Capital of YEMEN. Patients underwent thoracoscopic sympathectomy during the study period, which was from January 2017 to May 2020. A chest X-ray was performed the first day after surgery by 6 hours to exclude the possibility of pneumothorax, hemothorax or pulmonary atelectasis. The patient can discharge after 24 - 48 hours post operation.
2.1. Surgical Methods
The double-lumen endotracheal intubation was used for general anesthesia, and patients’ heart rate, blood pressure, and oxygen saturation were monitored during surgery. The position of patients was 30˚ - 45˚ half sitting, with arm overstretch. Two small incisions of about 0.5 cm were made, one in the 3rd intercostal space of the anterior axillary line and the other in the 5th intercostal space of the mid-clavicular line  . The thoracoscope is introduced through a port placed in the mid-clavicular line in the fifth intercostal space, the introduced the camera with zero degree angle lens. CO2 is insufflated to 8 - 10 cmH2O of pressure to collapse the dome of the lung. The thoracic chain is readily identified covered by the thin layer of the parietal pleura. A diathermy hook is inserted through the operating channel of the thoracoscope. The sympathetic chain is visualized behind the parietal pleura, which is then scored on either side using the cautery to delineate the position of the chain and the extent of the planned cauterization which corresponds to the extent of the chain destroyed. Using the ribs for reference, the sympathetic chain is then cauterized and divided from T2 to T3 for patients with predominantly palmar hyperhidrosis and from T2 to T4 for patients with predominantly axillary hyperhidrosis (can be extended to T5 to treat hyperhidrosis of the sole). Electrocautery ablation of the accessory branches and Kuntz nerve, when present, was performed in all cases to prevent relapse of the health status immediately before and six months after surgery  . The thoracoscope is then removed and replaced with a small red rubber catheter. With positive pressure ventilation, the catheter is then removed under suction to allow expansion of the lung  . The catheter was inserted and then pulled out after complete re-expansion of the lung, followed by a suturing of the incisions. The same procedure was performed on the other side. A chest X-ray was performed the first day after surgery by 6 hours to exclude the possibility of pneumothorax, hemothorax or pulmonary atelectasis  . The patient can discharge after 24 - 48 hours post operation.
Patient sweating was caused by metabolic diseases such as hyperthyroidism, hyper metabolism, tuberculosis, and other systematic diseases. Any case does other level of laparoscopic sympathectomy like lumber sympathectomy. Also any patient who hadn’t done previous thoracotomy.
Data collection: Patient’s data were collected by filling out a questionnaire from the patient’s file, and each patient was sent a questionnaire regarding success of the procedure, and compensatory sweating through their phone number by what App.
Data analysis: The success rate of bilateral thoracoscopic sympathectomy on hyperhidrosis patients, complicated cases and non-complicated cases.
The statistical data analysis will be done by computer using SPSS software program.
Ethical considerations: Approval of study and took a consent from patient about using their medical information.
Bilateral thoracoscopic sympathectomy was performed in 36 patients. The patients included 75% males, 25% females. In addition, the age range was 14 to 32 years old at the time of surgery, most of our patients were between 20 to 29 years old at time of surgery, as shown in Figure 1.
According to our study, we found 100% of sample complaining of palm hyperhidrosis, some of them associated with sole hyperhidrosis (58.3%), axilla and sole hyperhydrosis (41.7%). While 25% of patients had craniofacial symptoms like facial blushing, as shown in Figure 2.
All patients suffer from primary hyperhidrosis for a long time as childhood (94.5%), adolescent (5.5%), and have poor response to drug therapy, so they were advised to surgery.
Figure 1. Distribution of patients by age groups.
Figure 2. Distribution of patients by sit of excessive sweating.
In this study, we found the surgical technique and level of sympathectomy different according to the site of excessive sweating. Some patients underwent sympathectomy for T2 and T3 only especially in-patient who complains of palm hyperhidrosis without axilla hyperhidrosis, but if there was axillary hyperhidrosis the surgeon preferred to extend to T4 and T5. We found most of the patients had been done sympathectomy at T2, T3 and T4 (66.7%), but (25%) at T2, T3, T4 and T5, and (8.3%) only cauterized T2 and T3 as shown in Figure 3.
The success rate post-bilateral thoracoscopic sympathectomy was good; all patients (100%) improved from hyperhidrosis in palm, (94.4%) improved from excessive seating in sole and (100%) improved from axillary hyperhidrosis or facial blushing as shown in Table 1.
Hyperhidrosis is defined as sweating that disrupts normal activities. Episodes of excessive sweating occur at least once a week for no clear reason and have an effect on social life or daily activities. According to the International Hyperhidrosis Association, approximately 2.8 percent of Americans are affected by hyperhidrosis; that’s around 7.8 million peoples  . For some, hyperhidrosis symptoms are so severe that it becomes embarrassing, causing discomfort and anxiety. The patient’s career choices, free time activities, personal relationships, self-image, and emotional well-being may be affected  . In our study 22 - 29 years old (69.4%) period of age group, the patients whose more suffering from this problem (male > female), due to it is necessary to interact with society, and This age group is the beginning of public relations, so hyperhidrosis affected their social life and daily activities as shown in Figure 1.
Although its pathophysiology is unclear, it is believed to be caused by hyper-stimulation or over-activity of the sympathetic nervous system that passes through the upper thoracic ganglia. The diagnosis of primary hyperhidrosis is based on symptoms, and supported by a specific clinical history. Help is needed to distinguish focal from generalized hyperhidrosis. The Multi-Specialty Working Group on Hyperhydrosis in the United States has proposed some criteria for the diagnosis of focal hyperhidrosis   . We found significant improvement in symptoms of hyperhidrosis in the pre-operatively affected areas, all patients were complaining of palm or axillary hyperhidrosis, they improved immediately post operation, whereas patients complaining of sole hyperhidrosis most of them improved (94.4%), while (5.4%) not improved. Also patients those complaining of facial blushing pre-operatively improved after the operation (100%) as shown in Figure 3, Table 1. We think bilateral thoracoscopic sympathectomy for management of hyperhidrosis has a good result. In addition, it demonstrates that compensatory sweating is an almost unavoidable phenomenon post-operative and has related to level of sympathectomy, but this squeal infrequently improves with time.
Other study by Drott et al., reported the success rate was 98.6% on 850 patients treated by thoracoscopic sympathectomy. While in other study by T. S. Lin et al. published the results of sympathectomy performed on 2200 patients, reporting a successful treatment was 99%  . In additional study for 335 patients with severe primary hyperhidrosis by Murat Öncel et al., most of the patients presented with an improvement in primary hyperhidrosis. The initial cure rate was 95%, the axillary region in 42 (12.53%), and in the palmar and pedal regions in 22 (6.56%) patients  .
Figure 3. Distribution of patients by the level of sympathectomy.
Table 1. Distribution of site of sweating and their improvement post-operative.
Neelan Doolabh et al. study, they found the success rates were palmar 100% (109/109), axillary 98% (48/49), and face/scalp 93% (26/28). Plantar hyperhidrosis responded with improvement in 82% (72/88) of all patients  . So according to all mentioned above studies and to our study, bilateral thoracoscopic sympathectomy has a good result and high success rate.
In our study, we observed all patients improved from hyperhidrosis in palm, and some of patients improved in other site especially if sympathectomy level was at T4 and T5, like in axilla the improvement was 33.3%, and in sole the improvement was 94.4% when the sympathectomy level reach to T4 and T5. Only two cases were not improved from sole hyperhidrosis where the sympathectomy was T2 and T3 only as shown in Figure 3 & Table 1.
In Murat Öncel study, T2 resection was performed in 281 patients with craniofacial hyperhidrosis, T3 resection was performed in 94 patients with only palmar and only axillary hyperhidrosis, T3-T4 resection was performed in 175 patients with palmar and axillary hyperhyidrosis, and T3-T5 resection was performed in 22 patients with palmar and pedal hyperhidrosis, the initial cure rate was 95%  .
According to our data after operation, only two cases (5.6%) developed pneumothorax and they need chest drainage for 24 hours then discharge, and 6 cases (16.7%) complained of severe pain at site of operation and upper limb, this pain improved with time. No other early post operation complication or wound complication. No cases of persistent hyperhidrosis were observed after discharge as shown in Table 2.
In previous study by Pedro M. Rodríguez et al., there were complications in 23 patients (5.6%) consisting of: 16 cases of pneumothorax (3.9%) in which 11 were less than 20% and did not require pleural drainage, 2 cases of unilateral and transitory Horner syndrome (0.5%), 2 cases of hemothorax requiring pleural drainage (2.5%), 1 case of quilothorax (0.25%) treated with video-assisted thoracic surgery, 1 case of cubital nerve neuropraxia (0.25%) from which the patient recovered in 21 days, and 1 case of subcutaneous cervico-thoracic emphysema (0.25%)  .
Compensatory hyperhidrosis one of the main late post-operative complication occurred in half of patients (50%) in our study, 33% in back and chest and 17% in back and abdomen. The post-operative complication can be divided into early and
Table 2. Post-operative complications, CH: compensatory hyperhidrosis.
late. Early post-operative complications were two cases complicated by pneumothorax (5.6%), and six cases suffering from severe pain at site of operation (16.7%). Late post-operative complications were 18 cases whose represented 50% of patients, they complicated by compensatory hyperhidrosis in the trunk, as shown in Table 2. Other study by Z. Steiner et al has indicated a more variable response. Steiner et al. report immediate development of compensatory hyperhidrosis in half of respondents  . There is a relationship between level of sympathectomy and rate of compensatory hyperhidrosis. If we got level of sympathectomy low, the rate of sympathectomy increased. However, the highest rate (40.5%) of compensatory hyperhidrosis was found in cauterization 2nd, 3rd and 4th ganglions, because most of the cases were at this level. More extensive sympathectomy to the level of T4 or T5 is associated with increased compensatory hyperhidrosis rate, because during operation, there are more manipulation and more injury for sympathetic nerves as shown in Table 3 and Figure 4.
In Peter B. Licht et al. study, they found compensatory sweating occurred in 131 patients (89%), and was located on the abdomen in 83 patients (63%), the back in 90 patients (69%), the lower extremities in 56 patients (43%), and the chest in 26 patients (20%)  .
Table 3. Distribution of the post-operative complication.
Figure 4. Relationship between level of sympathectomy and rate of compensatory hyperhidrosis.
In C S Cinà et al. study, of the 22 patients who underwent surgery, one patient (5%) developed a postoperative pneumothorax requiring placement of a Heimlich valve. There were no other local or wound complications. No patient developed Horner’s syndrome or any other neurologic complication  . In study by M. Riet, et al., 28-thoracoscopic sympathectomy is for palmar and/or axillary hyperhidrosis. In all patients, the sympathetic chain was transected cranially and caudally to the third ganglion. The surgery was effective in all patients. After a median follow-up of 3.5 years, compensatory hyperhidrosis was not recorded in any of the patients  . We suggest that a more extensive sympathectomy to the level of T4 or T5 is associated with increased compensatory hyperhidrosis rate, because during operation, there more manipulation and injury more for sympathetic nerves. Mortality rate post-bilateral thoracoscopic sympathectomy is almost zero, so thoracoscopic sympathectomy is less invasive and safe.
・ Thoracic sympathectomy and its variations are the most valuable tools in the curative treatment for hyperhidrosis.
・ Those presenting with palmar hyperhidrosis are the most suitable for surgery as first-line treatment.
・ For patients with axilla, sole and/or facial complain, sympathectomy gives good results.
・ The surgery is performed by means of minimally invasive approaches and the complication’s rates are very low.
・ Nevertheless, the occurrence of compensatory hyperhidrosis should never be ignored and all maneuvers to prevent its occurrence.
・ Thoracoscopic sympathectomy is the best option for treated hyperhidrosis after failed medical management, to improve quality of patient life.
・ Thoracoscopic sympathectomy is low invasive operation, nearly no mortality rate and has good outcomes for patients.
・ Should inform the patient about post-operative complications especially compensatory hyperhidrosis.
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