Back
 CC  Vol.8 No.3 , July 2020
In Situ Characterization of Lopinavir by ATR-FTIR Biospectroscopy
Abstract: Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared.
Cite this paper: Heidari, A. (2020) In Situ Characterization of Lopinavir by ATR-FTIR Biospectroscopy. Computational Chemistry, 8, 27-42. doi: 10.4236/cc.2020.83004.
References

[1]   Stoll, V., Qin, W.Y., Stewart, K.D., Jakob, C., Park, C., Walter, K., Simmer, R.L., Helfrich, R., Bussiere, D., Kao, J., Kempf, D., Sham, H.L. and Norbeck, D.W. (2002) X-Ray Crystallographic Structure of ABT-378 (Lopinavir) Bound to HIV-1 Protease. Bioorganic & Medicinal Chemistry, 10, 2803-2806.
https://doi.org/10.1016/S0968-0896(02)00051-2

[2]   Heidari, A. and Brown, C. (2015) Study of Composition and Morphology of Cadmium Oxide (CdO) Nanoparticles for Eliminating Cancer Cells. Journal of Nanomedicine Research, 2, 20. https://doi.org/10.15406/jnmr.2015.02.00042

[3]   Heidari, A. and Brown, C. (2015) Study of Surface Morphological, Phytochemical and Structural Characteristics of Rhodium (III) Oxide (Rh2O3) Nanoparticles. International Journal of Pharmacology, Phytochemistry and Ethnomedicine, 1, 15-19.
https://doi.org/10.18052/www.scipress.com/IJPPE.1.15

[4]   Heidari, A. (2016) An Experimental Biospectroscopic Study on Seminal Plasma in Determination of Semen Quality for Evaluation of Male Infertility. International Journal of Advancements in Technology, 7, e007.
https://doi.org/10.4172/0976-4860.1000e007

[5]   Heidari, A. (2016) Extraction and Preconcentration of N-Tolyl-Sulfonyl-Phosph-oramid-Saeure-Dichlorid as an Anti-Cancer Drug from Plants: A Pharmacognosy Study. Journal of Pharmacognosy and Natural Products, 2, e103.
https://doi.org/10.4172/2472-0992.1000e103

[6]   Heidari, A. (2016) A Thermodynamic Study on Hydration and Dehydration of DNA and RNA-Amphiphile Complexes. Journal of Bioengineering and Biomedical Science, S, 006.
https://doi.org/10.4172/2155-9538.S3-006

[7]   Heidari, A. (2016) Computational Studies on Molecular Structures and Carbonyl and Ketene Groups’ Effects of Singlet and Triplet Energies of Azidoketene O=C=CH-NNN and Isocyanatoketene O=C=CH-N=C=O. Journal of Applied and Computational Mathematics, 5, e142. https://doi.org/10.4172/2168-9679.1000e142

[8]   Heidari, A. (2016) Study of Irradiations to Enhance the Induces the Dissociation of Hydrogen Bonds between Peptide Chains and Transition from Helix Structure to Random Coil Structure Using ATR-FTIR, Raman and 1HNMR Spectroscopies. Journal of Biomolecular Research and Therapeutics, 5, e146.
https://doi.org/10.4172/2167-7956.1000e146

[9]   Heidari, A. (2016) Future Prospects of Point Fluorescence Spectroscopy, Fluorescence Imaging and Fluorescence Endoscopy in Photodynamic Therapy (PDT) for Cancer Cells. Journal of Bioanalysis & Biomedicine, 8, e135.
https://doi.org/10.4172/1948-593X.1000e135

[10]   Heidari, A. (2016) A Bio-Spectroscopic Study of DNA Density and Color Role as Determining Factor for Absorbed Irradiation in Cancer Cells. Advance in Cancer Prevention, 1, e102. https://doi.org/10.4172/2472-0429.1000e102

[11]   Heidari, A. (2016) Manufacturing Process of Solar Cells Using Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) Nanoparticles. Journal of Biotechnology and Biomaterials, 6, e125. https://doi.org/10.4172/2155-952X.1000e125

[12]   Heidari, A. (2016) A Novel Experimental and Computational Approach to Photobiosimulation of Telomeric DNA/RNA: A Biospectroscopic and Photobiological Study. Journal of Research & Development, 4, 144.
https://doi.org/10.21767/2254-6081.100086

[13]   Heidari, A. (2016) Biochemical and Pharmacodynamical Study of Microporous Molecularly Imprinted Polymer Selective for Vancomycin, Teicoplanin, Oritavancin, Telavancin and Dalbavancin Binding. Biochemistry and Physiology, 5, e146.
https://doi.org/10.4172/2168-9652.1000e146

[14]   Heidari, A. (2016) Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study. Archives in Cancer Research, 4, 1.
https://doi.org/10.21767/2254-6081.100061

[15]   Heidari, A. (2016) Biospectroscopic Study on Multi-Component Reactions (MCRs) in Two A-Type and B-Type Conformations of Nucleic Acids to Determine Ligand Binding Modes, Binding Constant and Stability of Nucleic Acids in Cadmium Oxide (CdO) Nanoparticles-Nucleic Acids Complexes as Anti-Cancer Drugs. Archives in Cancer Research, 4, 2.
https://doi.org/10.21767/2254-6081.100065

[16]   Heidari, A. (2016) Simulation of Temperature Distribution of DNA/RNA of Human Cancer Cells Using Time-Dependent Bio-Heat Equation and Nd:YAG Lasers. Archives in Cancer Research, 4, 2. https://doi.org/10.21767/2254-6081.100069

[17]   Heidari, A. (2016) Quantitative Structure-Activity Relationship (QSAR) Approximation for Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) Nanoparticles as Anti-Cancer Drugs for the Catalytic Formation of Proviral DNA from Viral RNA Using Multiple Linear and Non-Linear Correlation Approach. Annals of Clinical and Laboratory Research, 4, 1.
https://doi.org/10.21767/2386-5180.100076

[18]   Heidari, A. (2016) Biomedical Study of Cancer Cells DNA Therapy Using Laser Irradiations at Presence of Intelligent Nanoparticles. Journal of Biomedical Science, 5, 2.
https://doi.org/10.4172/2254-609X.100023

[19]   Heidari, A. (2016) Measurement the Amount of Vitamin D2 (Ergocalciferol), Vitamin D3 (Cholecalciferol) and Absorbable Calcium (Ca2+), Iron (II) (Fe2+), Magnesium (Mg2+), Phosphate (PO¯4) and Zinc (Zn2+) in Apricot Using High-Performance Liquid Chromatography (HPLC) and Spectroscopic Techniques. Journal of Biometrics and Biostatistics, 7, 292.
https://doi.org/10.4172/2155-6180.1000292

[20]   Heidari, A. (2016) Spectroscopy and Quantum Mechanics of the Helium Dimer (He2+), Neon Dimer (Ne2+), Argon Dimer (Ar2+), Krypton Dimer (Kr2+), Xenon Dimer (Xe2+), Radon Dimer (Rn2+) and Ununoctium Dimer (Uuo2+) Molecular Cations. Chemical Sciences Journal, 7, e112.
https://doi.org/10.4172/2150-3494.1000e112

[21]   Heidari, A. (2016) Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio-Spectroscopic Techniques. Journal of Drug Metabolism and Toxicology, 7, e129. https://doi.org/10.4172/2157-7609.1000e129

[22]   Heidari, A. (2016) Novel and Stable Modifications of Intelligent Cadmium Oxide (CdO) Nanoparticles as Anti-Cancer Drug in Formation of Nucleic Acids Complexes for Human Cancer Cells’ Treatment. Biochemical Pharmacology (Los Angel), 5, 207. https://doi.org/10.4172/2167-0501.1000207

[23]   Heidari, A. (2016) A Combined Computational and QM/MM Molecular Dynamics Study on Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs) as Hydrogen Storage. Structural Chemistry & Crystallography Communication, 2, 1.

[24]   Heidari, A. (2016) Pharmaceutical and Analytical Chemistry Study of Cadmium Oxide (CdO) Nanoparticles Synthesis Methods and Properties as Anti-Cancer Drug and its Effect on Human Cancer Cells. Pharmaceutical Analytical Chemistry: Open Access, 2, 113.
https://doi.org/10.4172/2471-2698.1000113

[25]   Heidari, A. (2016) A Chemotherapeutic and Biospectroscopic Investigation of the Interaction of Double-Standard DNA/RNA-Binding Molecules with Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh2O3) Nanoparticles as Anti-Cancer Drugs for Cancer Cells’ Treatment. Chemotherapy: Open Access, 5, e129.
https://doi.org/10.4172/2167-7700.1000e129

[26]   Heidari, A. (2016) Pharmacokinetics and Experimental Therapeutic Study of DNA and Other Biomolecules Using Lasers: Advantages and Applications. Journal of Pharmacokinetics and Experimental Therapeutics, 1, e005.

[27]   Heidari, A. (2016) Determination of Ratio and Stability Constant of DNA/RNA in Human Cancer Cells and Cadmium Oxide (CdO) Nanoparticles Complexes Using Analytical Electrochemical and Spectroscopic Techniques. Insights in Analytical Electrochemistry, 2, 1.
https://doi.org/10.21767/2470-9867.1000e101

[28]   Heidari, A. (2016) Discriminate between Antibacterial and Non-Antibacterial Drugs Artificial Neutral Networks of a Multilayer Perceptron (MLP) Type Using a Set of Topological Descriptors. Journal of Heavy Metal Toxicity and Diseases, 1, 2.
https://doi.org/10.21767/2473-6457.100009

[29]   Heidari, A. (2016) Combined Theoretical and Computational Study of the Belousov-Zhabotinsky Chaotic Reaction and Curtius Rearrangement for Synthesis of Mechlorethamine, Cisplatin, Streptozotocin, Cyclophosphamide, Melphalan, Busulphan and BCNU as Anti-Cancer Drugs. Insights in Medical Physics, 1, 2.
https://doi.org/10.21767/2472-1956.100015

[30]   Heidari, A. (2016) A Translational Biomedical Approach to Structural Arrangement of Amino Acids’ Complexes: A Combined Theoretical and Computational Study. Translational Biomedicine, 7, 2. https://doi.org/10.21767/2172-0479.100072

[31]   Heidari, A. (2016) Ab Initio and Density Functional Theory (DFT) Studies of Dynamic NMR Shielding Tensors and Vibrational Frequencies of DNA/RNA and Cadmium Oxide (CdO) Nanoparticles Complexes in Human Cancer Cells. Journal of Nanomedicine and Biotherapeutic Discovery, 6, e144.
https://doi.org/10.4172/2155-983X.1000e144

[32]   Heidari, A. (2016) Molecular Dynamics and Monte-Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study. Journal of Glycobiology, 5, e111.
https://doi.org/10.4172/2168-958X.1000e111

[33]   Heidari, A. (2016) Synthesis and Study of 5-[(Phenylsulfonyl)Amino]-1,3,4-Thiadiazole-2-Sulfonamide as Potential Anti-Pertussis Drug Using Chromatography and Spectroscopy Techniques. Journal of Translational Medicine (Sunnyvale), 6, e138.
https://doi.org/10.4172/2161-1025.1000e137

[34]   Heidari, A. (2016) Nitrogen, Oxygen, Phosphorus and Sulphur Heterocyclic Anti-Cancer Nano Drugs Separation in the Supercritical Fluid of Ozone (O3) Using Soave-Redlich-Kwong (SRK) and Pang-Robinson (PR) Equations. Electronic Journal of Biology, 12, 4.

[35]   Heidari, A. (2016) An Analytical and Computational Infrared Spectroscopic Review of Vibrational Modes in Nucleic Acids. Austin Journal of Analytical and Pharmaceutical Chemistry, 3, 1058.

[36]   Heidari, A. and Brown, C. (2016) Phase, Composition and Morphology Study and Analysis of Os-Pd/HfC Nanocomposites. Nano Research & Applications, 2, 1.

[37]   Heidari, A. and Brown, C. (2016) Vibrational Spectroscopic Study of Intensities and Shifts of Symmetric Vibration Modes of Ozone Diluted by Cumene. International Journal of Advanced Chemistry, 4, 5-9. https://doi.org/10.14419/ijac.v4i1.6080

[38]   Heidari, A. (2016) Study of the Role of Anti-Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues. Archives of Medical Research, 4, 2. https://doi.org/10.21767/2254-6081.100083

[39]   Heidari, A. (2016) Genomics and Proteomics Studies of Zolpidem, Necopidem, Alpidem, Saripidem, Miroprofen, Zolimidine, Olprinone and Abafungin as Anti-Tumor, Peptide Antibiotics, Antiviral and Central Nervous System (CNS) Drugs. Journal of Data mining in Genomics and Proteomics, 7, e125.
https://doi.org/10.4172/2153-0602.1000e125

[40]   Heidari, A. (2016) Pharmacogenomics and Pharmacoproteomics Studies of Phosphodiesterase-5 (PDE5) Inhibitors and Paclitaxel Albumin-Stabilized Nanoparticles as Sandwiched Anti-Cancer Nano Drugs between Two DNA/RNA Molecules of Human Cancer Cells. Journal of Pharmacogenomics and Pharmacoproteomics, 7, e153.
https://doi.org/10.4172/2153-0645.1000e153

[41]   Heidari, A. (2016) Biotranslational Medical and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles-DNA/RNA Straight and Cycle Chain Complexes as Potent Anti-Viral, Anti-Tumor and Anti-Microbial Drugs: A Clinical Approach. Translational Biomedicine, 7, 2. https://doi.org/10.21767/2172-0479.100076

[42]   Heidari, A. (2016) A Comparative Study on Simultaneous Determination and Separation of Adsorbed Cadmium Oxide (CdO) Nanoparticles on DNA/RNA of Human Cancer Cells Using Biospectroscopic Techniques and Dielectrophoresis (DEP) Method. Archives of Medical Research, 4, 2.
https://doi.org/10.21767/2254-6081.100086

[43]   Heidari, A. (2016) Cheminformatics and System Chemistry of Cisplatin, Carboplatin, Nedaplatin, Oxaliplatin, Heptaplatin and Lobaplatin as Anti-Cancer Nano Drugs: A Combined Computational and Experimental Study. Journal of Information and Data Mining, 1, 3.
https://doi.org/10.21767/2472-1956.100015

[44]   Heidari, A. (2016) Linear and Non-Linear Quantitative Structure-Anti-Cancer-Activity Relationship (QSACAR) Study of Hydrous Ruthenium (IV) Oxide (RuO2) Nanoparticles as Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Anti-Cancer Nano Drugs. Journal of Integrative Oncology, 5, e110.
https://doi.org/10.4172/2329-6771.1000e110

[45]   Heidari, A. (2016) Synthesis, Characterization and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles-Nucleic Acids Complexes Absence of Soluble Polymer as a Protective Agent Using Nucleic Acids Condensation and Solution Reduction Method. Journal of Nanosciences: Current Research, 1, e101.
https://doi.org/10.4172/2572-0813.1000e101

[46]   Heidari, A. (2016) Coplanarity and Collinearity of 4’-Dinonyl-2,2’-Bithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti-Tumor Nano Drug. International Journal of Drug Development and Research, 8, 007-008.

[47]   Heidari, A. (2016) A Pharmacovigilance Study on Linear and Non-Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for the Prediction of Retention Time of Anti-Cancer Nano Drugs under Synchrotron Radiations. Journal of Pharmacovigilance, 4, e161.
https://doi.org/10.4172/2329-6887.1000e161

[48]   Heidari, A. (2016) Nanotechnology in Preparation of Semipermeable Polymers. Journal of Advanced Chemical Engineering, 6, 157.
https://doi.org/10.4172/2090-4568.1000157

[49]   Heidari, A. (2016) A Gastrointestinal Study on Linear and Non-Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5-Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations. Journal of Gastrointestinal and Digestive System, 6, e119.
https://doi.org/10.4172/2161-069X.1000e119

[50]   Heidari, A. (2016) DNA/RNA Fragmentation and Cytolysis in Human Cancer Cells Treated with Diphthamide Nano Particles Derivatives. Biomedical Data Mining, 5, e102.
https://doi.org/10.4172/2090-4924.1000e102

[51]   Heidari, A. (2016) A Successful Strategy for the Prediction of Solubility in the Construction of Quantitative Structure-Activity Relationship (QSAR) and Quantitative Structure-Property Relationship (QSPR) under Synchrotron Radiations Using Genetic Function Approximation (GFA) Algorithm. Journal of Molecular Biology and Biotechnology, 1, 1.
https://doi.org/10.4172/2376-0249.1000516

[52]   Heidari, A. (2016) Computational Study on Molecular Structures of C20, C60, C240, C540, C960, C2160 and C3840 Fullerene Nano Molecules under Synchrotron Radiations Using Fuzzy Logic. Journal of Materials Science and Engineering, 5, 282.
https://doi.org/10.4172/2169-0022.1000282

[53]   Heidari, A. (2016) Graph Theoretical Analysis of Zigzag Polyhexamethylene Biguanide, Polyhexamethylene Adipamide, Polyhexamethylene Biguanide Gauze and Polyhexamethylene Biguanide Hydrochloride (PHMB) Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs). Journal of Applied and Computational Mathematics, 5, e143. https://doi.org/10.4172/2168-9679.1000e143

[54]   Heidari, A. (2016) The Impact of High Resolution Imaging on Diagnosis. International Journal of Clinical & Medical Images, 3, 1000e101.
https://doi.org/10.4172/2376-0249.1000e101

[55]   Heidari, A. (2016) A Comparative Study of Conformational Behavior of Isotretinoin (13-Cis Retinoic Acid) and Tretinoin (All-Trans Retinoic Acid (ATRA)) Nano Particles as Anti-Cancer Nano Drugs under Synchrotron Radiations Using Hartree-Fock (HF) and Density Functional Theory (DFT) Methods. Insights in Biomedicine, 1, 2.

[56]   Heidari, A. (2016) Advances in Logic, Operations and Computational Mathematics. Journal of Applied and Computational Mathematics, 5, 5.
https://doi.org/10.4172/2168-9679.1000e144

[57]   Heidari, A. (2016) Mathematical Equations in Predicting Physical Behavior. Journal of Applied and Computational Mathematics, 5, 5.
https://doi.org/10.4172/2168-9679.1000e145

[58]   Heidari, A. (2016) Chemotherapy a Last Resort for Cancer Treatment. Chemotherapy: Open Access, 5, 4. https://doi.org/10.4172/2167-7700.1000e130

[59]   Heidari, A. (2016) Separation and Pre-Concentration of Metal Cations-DNA/RNA Chelates Using Molecular Beam Mass Spectrometry with Tunable Vacuum Ultraviolet (VUV) Synchrotron Radiation and Various Analytical Methods. Mass Spectrometry & Purification Techniques, 2, e101.
https://doi.org/10.4172/2469-9861.1000e101

[60]   Heidari, A. (2016) Yoctosecond Quantitative Structure-Activity Relationship (QSAR) and Quantitative Structure-Property Relationship (QSPR) under Synchrotron Radiations Studies for Prediction of Solubility of Anti-Cancer Nano Drugs in Aqueous Solutions Using Genetic Function Approximation (GFA) Algorithm. Insight Pharma Reports, 1, 1.

[61]   Heidari, A. (2016) Cancer Risk Prediction and Assessment in Human Cells under Synchrotron Radiations Using Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Properties Relationship (QSPR) Studies. International Journal of Clinical & Medical Images, 3, 516.
https://doi.org/10.4172/2376-0249.1000516

[62]   Heidari, A. (2016) A Novel Approach to Biology. Electronic Journal of Biology, 12, 4.

[63]   Heidari, A. (2016) Innovative Biomedical Equipment’s for Diagnosis and Treatment. Journal of Bioengineering and Biomedical Science, 6, 1000e124.
https://doi.org/10.4172/2155-9538.1000e124

[64]   Heidari, A. (2016) Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology: Trends in Oncology Medicine and Practices. Journal of Oncology Medicine and Practice, 1, 1000e126.
https://doi.org/10.4172/2155-9538.1000e126

[65]   Heidari, A. (2016) Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives. Journal of Bioengineering and Biomedical Science, 6, 3.

[66]   Heidari, A. (2017) X-Ray Fluorescence and X-Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design. Journal of Powder Metallurgy & Mining, 6, 1.

[67]   Heidari, A. (2017) Biomolecular Spectroscopy and Dynamics of Nano-Sized Molecules and Clusters as Cross-Linking-Induced Anti-Cancer and Immune-Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells’ Membranes under Synchrotron Radiations: A Payload-Based Perspective. Archives in Chemical Research, 1, 2. https://doi.org/10.21767/2572-4657.100011

[68]   Heidari, A. (2017) Deficiencies in Repair of Double-Standard DNA/RNA-Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis: Number of Mutations in a Synchronous Tumor Varies by Age and Type of Synchronous Cancer. Journal of Applied Bioinformatics & Computational Biology, 6, 1. https://doi.org/10.4172/2329-9533.1000e104

[69]   Heidari, A. (2017) Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing. Global Journal of Research and Review, 4, 2.
https://doi.org/10.21767/2393-8854.100019

[70]   Heidari, A. (2017) Polymorphism in Nano-Sized Graphene Ligand-Induced Transformation of Au38-xAgx/xCux(SPh-tBu)24 to Au36-xAgx/xCux(SPh-tBu)24 (x = 1-12) Nanomolecules for Synthesis of Au144-xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p-MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano Clusters as Anti-Cancer Nano Drugs. Journal of Nanomaterials & Molecular Nanotechnology, 6, 3.
https://doi.org/10.4172/2324-8777.1000109e

[71]   Heidari, A. (2017) Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. International Journal of Biomedical Data Mining, 6, e103.
https://doi.org/10.4172/2090-4924.1000e103

[72]   Heidari, A. (2017) Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation. Journal of Developing Drugs, 6, e154. https://doi.org/10.4172/2329-6631.1000e154

[73]   Heidari, A. (2017) A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer’s, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke. Journal of Bioengineering and Biomedical Science, 7, e127. https://doi.org/10.4172/2155-9538.1000e127

[74]   Heidari, A. (2017) Opinion on Computational Fluid Dynamics (CFD) Technique. Fluid Mechanics: Open Access, 4, 157. https://doi.org/10.4172/2476-2296.1000157

[75]   Heidari, A. (2017) Concurrent Diagnosis of Oncology Influence Outcomes in Emergency General Surgery for Colorectal Cancer and Multiple Sclerosis (MS) Treatment Using Magnetic Resonance Imaging (MRI) and Au329(SR)84, Au329-xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 Nano Clusters. Journal of Surgery and Emergency Medicine, 1, 21.

[76]   Heidari, A. (2017) Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy). Cell Biology (Henderson, NV), 6, e117.
https://doi.org/10.4172/2324-9293.1000e117

[77]   Heidari, A. (2017) Changing Metal Powder Characteristics for Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins Adjustment in Cancer Metastases Induced by Osteosarcoma, Chondrosarcoma, Carcinoid, Carcinoma, Ewing’s Sarcoma, Fibrosarcoma and Secondary Hematopoietic Solid or Soft Tissue Tumors. Journal of Powder Metallurgy & Mining, 6, 170. https://doi.org/10.4172/2168-9806.1000170

[78]   Heidari, A. (2017) Nanomedicine-Based Combination Anti-Cancer Therapy between Nucleic Acids and Anti-Cancer Nano Drugs in Covalent Nano Drugs Delivery Systems for Selective Imaging and Treatment of Human Brain Tumors Using Hyaluronic Acid, Alguronic Acid and Sodium Hyaluronate as Anti-Cancer Nano Drugs and Nucleic Acids Delivery under Synchrotron Radiation. American Journal of Drug Delivery, 5, 2. https://doi.org/10.21767/2321-547X.1000016

[79]   Heidari, A. (2017) Clinical Trials of Dendritic Cell Therapies for Cancer Exposing Vulnerabilities in Human Cancer Cells’ Metabolism and Metabolomics: New Discoveries, Unique Features Inform New Therapeutic Opportunities, Biotech’s Bumpy Road to the Market and Elucidating the Biochemical Programs That Support Cancer Initiation and Progression. Journal of Biological and Medical Sciences, 1, e103.

[80]   Heidari, A. (2017) The Design Graphene-Based Nanosheets as a New Nanomaterial in Anti-Cancer Therapy and Delivery of Chemotherapeutics and Biological Nano Drugs for Liposomal Anti-Cancer Nano Drugs and Gene Delivery. British Biomedical Bulletin, 5, 305.

[81]   Haidari, A. (2017) Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation. Transcriptomics, 5, e117.
https://doi.org/10.4172/2329-8936.1000e117

[82]   Heidari, A. (2017) Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation. Letters in Health and Biological Sciences, 2, 1-4.
https://doi.org/10.15436/2475-6245.17.019

[83]   Heidari, A. (2017) Treatment of Breast Cancer Brain Metastases through a Targeted Nanomolecule Drug Delivery System Based on Dopamine Functionalized Multi-Wall Carbon Nanotubes (MWCNTs) Coated with Nano Graphene Oxide (GO) and Protonated Polyaniline (PANI) in Situ During the Polymerization of Aniline Autogenic Nanoparticles for the Delivery of Anti-Cancer Nano Drugs under Synchrotron Radiation. British Journal of Research, 4, 16.
https://doi.org/10.21767/2394-3718.100016

[84]   Heidari, A. (2017) Sedative, Analgesic and Ultrasound-Mediated Gastrointestinal Nano Drugs Delivery for Gastrointestinal Endoscopic Procedure, Nano Drug-Induced Gastrointestinal Disorders and Nano Drug Treatment of Gastric Acidity. Research and Reports in Gastroenterology, 1, 1.

[85]   Heidari, A. (2017) Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat High Cholesterol and Related Conditions and to Prevent Cardiovascular Disease under Synchrotron Radiation. Journal of Pharmaceutical Sciences & Emerging Drugs, 5, e104.
https://doi.org/10.4172/2380-9477.1000e104

[86]   Heidari, A. (2017) Non-Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams. Journal of Cell Biology and Molecular Science, 2, 1-5.

[87]   Heidari, A. (2017) Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood-Brain Barrier (BBB) Translocation to Targeted Deliver Anti-Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation. Journal of Nanotechnology & Material Science, 4, 1-5. https://doi.org/10.15436/2377-1372.17.1591

[88]   Gobato, R. and Heidari, A. (2017) Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi. Science Journal of Analytical Chemistry, 5, 76-85.
https://doi.org/10.11648/j.sjac.20170505.13

[89]   Heidari, A. (2017) Different High-Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti-Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X-Ray Radiations. Journal of Medical Oncology, 1, 1.
https://doi.org/10.36959/915/571

[90]   Heidari, A. (2017) A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation. American Journal of Ethnomedicine, 4, 10.

[91]   Heidari, A. (2017) Active Targeted Nanoparticles for Anti-Cancer Nano Drugs Delivery across the Blood-Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer’s Diseases Using Chemical Modifications of Anti-Cancer Nano Drugs or Drug-Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. Journal of Medicinal Chemistry and Toxicology, 2, 1-5. https://doi.org/10.15436/2575-808X.17.1594

[92]   Heidari, A. (2017) Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti-Microbial Agents and Anti-Cancer Nano Drugs in Nanomedicines Based Drug Delivery Systems for Anti-Cancer Targeting and Treatment. Parana Journal of Science and Education, 3, 10-19.

[93]   Heidari, A. (2017) A Comparative Computational and Experimental Study on Different Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open Journal of Analytical and Bioanalytical Chemistry, 1, 14-20.
https://doi.org/10.17352/ojabc.000003

[94]   Heidari, A. (2017) Combination of DNA/RNA Ligands and Linear/Non-Linear Visible-Synchrotron Radiation-Driven N-Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti-Cancer Activity. Enzyme Engineering, 6, 1.

[95]   Heidari, A. (2017) Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta-2 Transferrin and Bacterioferritin-Based Anti-Cancer Nano Drugs Encapsulating Nanosphere as DNA-Binding Proteins from Starved Cells (DPS). Modern Approaches in Drug Designing, 1, MADD.000504.
https://doi.org/10.31031/MADD.2017.01.000504

[96]   Heidari, A. (2017) Potency of Human Interferon β-1a and Human Interferon β-1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells. Journal of Proteomics & Enzymology, 6, e109.
https://doi.org/10.4172/2470-1289.1000e109

[97]   Heidari, A. (2017) Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti-Cancer Nanodrugs Delivery across the Blood-Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. Journal of Pharmacy and Pharmaceutics, 4, 1-5.
https://doi.org/10.15436/2377-1313.17.034

[98]   Heidari, A. and Brown, C. (2017) Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti-Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Annals of Advances in Chemistry, 1, 61-69.
https://doi.org/10.29328/journal.aac.1001008

[99]   Heidari, A. (2017) High-Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation. Journal of Translational Research, 1, 1-3. https://doi.org/10.36959/915/571

[100]   Heidari, A. (2017) Investigation of Anti-Cancer Nano Drugs’ Effects’ Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X-Ray Radiations with the Passage of Time Using Mathematica. Current Trends in Analytical and Bioanalytical Chemistry, 1, 36-41.
https://doi.org/10.36959/525/437

[101]   Heidari, A. (2017) Pros and Cons Controversy on Molecular Imaging and Dynamics of Double-Standard DNA/RNA of Human Preserving Stem Cells-Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium-4 Nucleus (Alpha Particle) Using Synchrotron Radiation. Archives of Biotechnology and Biomedicine, 1, 67-100.
https://doi.org/10.29328/journal.hjb.1001007

[102]   Heidari, A. (2017) Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy and Self-Organizing Maps under Synchrotron Radiation. SOJ Materials Science & Engineering, 5, 1-6.
https://doi.org/10.15226/sojmse.2017.00150

[103]   Heidari, A. (2017) Cavity Ring-Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Challenges in Cancer Detection and Therapy, 4, e001.
https://doi.org/10.18650/2376-046X.21008

 
 
Top