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Biography

Dr. Eduardo A Garcia Zepeda

Department of Immunology

Instituto de Investigaciones Biomedicas

Universidad NacionalAutonoma de Mexico

Associate Professor


Email: garciaze@unam.mx(preferred), garciaze@biomedicas.unam.mx


Research field:

Chronic Inflammatory Lung Diseases, Immunology


Qualifications

1992 Ph.D., Tropical Health Program, QIMR, University of Queensland, Australia

1987 M.S., Basic Biomedical Research, Universidad Nacional Autonoma de Mexico, Mexico

1983 B.S., Chemistry, Universidad Autonoma del Estado de Mexico, Mexico


Publications (selected)

  1. GARCÍA-ZEPEDA E. A., Rothenberg M.E., Ownbey, R. T., Celestin, J., Leder, P. and Luster, A. D.. Human eotaxinis a specific chemoattractant foreosinophilcells and provides a new mechanism to explain tissue eosinophilia. 1996 Nature Medicine 2, 449-456.
  2. GARCÍA-ZEPEDA E. A., Combadiere, C., Rothenberg, M.E., Sarafi, M., Hamid, Q., Murphy, P.M. and Luster, A.D.Human Monocyte Chemoattractant Protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and non-allergic inflammation that signals through the CC chemokinereceptors CCR-2b and -3. 1996. J Immunol. 157, 5613-5626.
  3. Sarafi, M. N., GARCÍA-ZEPEDA E. A., MacLean, J. A., Charo, I. F., and Luster, A. D.. Murinemonocyte chemoattractant protein (MCP)-5: A novel structural and functional homologue of human MCP-1. 1997. ExpMed. 185, 99-109.
  4. Lilly, C. M., Nakamura, H., Kesselman, H., Nagler-Anderson,C., Asano K, GARCÍA-ZEPEDA E. A.,Rothenberg, M. E., Drazen, J. M., Luster, A. D.1997. Expression of eotaxin by human lung epithelialcelllines: induction by cytokines and inhibition by glucocorticoids. J. Clin. Invest. 99, 1767-1773.
  5. Ayehunie, S., GARCÍA-ZEPEDA E. A.,, R. M.Human immunodeficiency virus-1 entry into purified blooddendritic cells through CC and CXC chemokinecoreceptors. 1997.Blood 90, 1379-1386.
  6. Lamkhioued, B., Renzi, P. M., Ab-Younes, S., GARCÍA-ZEPEDA E. A., Luster, A. D., Hamid, Q.Increasedexpression of eotaxin in BAL and airways of asthmaticscontributestothe chemotaxis of eosinophils tothesite of inflammation. 1997. J. Immunol. 159, 4593-4601.
  7. Minshall, E., Cameron, L., Lavigne, F., Leung, D. M., Hamilos, D., GARCÍA-ZEPEDA E. A.,, Rothenberg, M. E., Luster, A. D., Hamid, Q.. EotaxinmRNAexpression in chronic sinusitis and allergen-induced nasal responses isseasonalallergicrhinitis. 1997.Am. J. Resp. Cell Mol. Biol. 17, 683-690.
  8. Wagner, L., Yang, O. O., GARCÍA-ZEPEDA E. A., Ge, Y., Kalams, S., Walker, B. D., Pasternack, M., Luster, A. D.Beta-Chemokines are Released from HIV-1 Specific Cytolytic T-cell Granules Complexed to Proteoglycans. 1998. Nature 391, 908-911.
  9. Huang, W. W., GARCÍA-ZEPEDA E. A., Sauty, A., Oettgen, H. C., Rothenberg, M. E., Luster A. D. Molecular and biologicalcharacterization of themurineleukotriene B4 receptor expressedon eosinophils. 1998. J. ExpMed 188, 1063-1074.
  10. Sauty A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., GARCÍA-ZEPEDA E. A.,Hamid, Q., Luster, A. D. The T Cell-Specific CXC Chemokines IP-10, Mig and I-TAC are expressedbyactivated human bronchialepithelialcells. 1999. J. Immunol. 162, 3549-3558.
  11. Gerszten, R. E., GARCÍA-ZEPEDA, E. A., Lim, Y. C., Yoshida, M., Ding, H. A., Gimbrone, M. A. Jr., Luster, A. D., Luscinskas, F. W., Rosenzweig, A.. MCP-1 and IL-8 triggerfirmadhesion of monocytesto vascular endotheliumunderflowconditions. 1999. Nature 398, 718-723.
  12. Lamkhioued, B., GARCÍA-ZEPEDA E. A., Abi-Younes, S., Nakamura, H., Jedrzkiewicz ,S., Wagner, L., Renzi, P. M., Allakhverdi, Z., Lilly, C., Hamid, Q., Luster, A. D. Monocyte chemoattractant protein (MCP)-4 expression in theairways of patientswithasthma. Induction in epithelialcells and mononuclear cellsbyproinflammatorycytokines. 2000. Am. J. Resp. Crit. Car. Med. 162, 723-732.
  13. Lilly, C. M., Nakamura, H., Belostotsky, O. I., Haley, K. J., GARCÍA-ZEPEDA E. A., Drazen, J. M., Luster, A.D., Israel, E. Eotaxinexpressionaftersegmentalallergenchallenge in atoipicasthmatics. 2001. Am. J. Respir. Crit. CareMed. 163, 1669-1675.
  14. Nakamura, H., Luster A. D., Tateno, H., Jedrzkiewicz, S., Tamura, G., Haley, K., GARCÍA-ZEPEDA E. A., Yamaguchi, K., Lilly, C. M.IL-4 differentiallyregulateseotaxin and MCP-4 in lungepithelium and circulating mononuclear cells. 2001.Am J PhysiolLungCell Mol Physiol. 2001 Nov;281(5):L1288-302.
  15. Soldevila, G., Licona, I., Salgado, A., Ramírez, M., Chávez, R., GARCÍA-ZEPEDA E. A., 2004. Impairedchemokineinducedmigrationduring T celldevelopment in theabscence of Jak3. Immunology112, 191-200
  16. GARCÍA-ZEPEDA E. A.,Liconal, I., Solomon, F., Soldevila, G. Jak3 deficient T lymphocyteshaveanintrinsicdefect in CCR7-mediated homingtoperipherallymphoidorgans. 2007. Immunology.122, 247–260.
  17. Mendez, E., Meléndez, Y., Martinez, F., Huerta, S., Fortoul, T. I., Soldevila, G., and GARCÍA-ZEPEDA E. A. 2008. CDIP-2, a syntheticpeptidederivedfrom CCL13 chemokine, amelioratesallergicairwayinflammation. Clin. Exp. Immunol. 152(2):354-63.
  18. Huerta-Yépez, S.,Baay-Guzman, G.J., GARCIA-ZEPEDA, R., Hernández-Pando, R, M.I. Vega, MI., C. Gonzalez-Bonilla, C,. Bonavida, B. 2-Methoxyestradiol (2-ME) reduces theairway. inflammation and remodeling in an experimental mouse model.2008. ClinImmunol. 129, 313–324
  19. Rivas, C., Flores, L., Castell., M., Soldevila, G., GARCÍA-ZEPEDA E. A.. Jak3 IsInvolved in DendriticCellMaturation and CCR7-Dependent Migration.PLoSOne. 2009 Sep 17;4(9):e7066. doi: 10.1371/journal.pone.0007066
  20. Baay-Guzman, GJ., Bebenek,IG , Zeidler, M, Hernandez-Pando, R.,Vega, MI,GARCÍA-ZEPEDA E. A., Antonio-Andres, G., Bonavida, B., Riedl, M., Kleerup, E., Tashkin, DP., Hankinson. O., Huerta-Yepez. S. HIF-1 expressionisassociatedwith CCL2 chemokineexpression in airwayinflammatorycells: implications in allergicairwayinflammation.. 2012. Resp. Res, 13:60-71
  21. Ramos-Ramírez P, Campos MG, Martínez-Cordero E, Bazán-Perkins B, GARCÍA-ZEPEDA EAntigen-inducedairway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs.2013 ExpLung Res. Apr;39(3):136-45.
  22. Mendez-Enriquez E, GARCÍA-ZEPEDA EA.Themultiple faces of CCL13 in immunity and inflammation.2013. Inflammopharmacology 21:397–406.
  23. Ambriz-Peña, X., GARCÍA-ZEPEDA EA, Meza, I and Gloria Soldevila.Jak3 enables chemokine-dependent actin cytoskeleton reorganizationby regulating cofilin and Rac/RhoAGTPases activation2014. PlosOne.Feb 3;9(2):e88014. doi: 10.1371
  24. Rodriguez-Lara V, Peña-Mirabal E, Baez-Saldaña R, Esparza-Silva AL, GARCÍA-ZEPEDA E, Cerbon Cervantes MA, Diaz D, Fortoul TI.Estrogen Receptor Beta and CXCR4/CXCL12 Expression: Differences by Sex and Hormonal Status in Lung Adenocarcinoma.2014. Arch Med Res. Feb;45(2):158-69
  25. Méndez-Enríquez E, Medina-Tamayo J, Soldevila G, Fortoul TI, Anton B, Flores-Romo L, GARCÍA-ZEPEDA EA.A CCL chemokine-derived peptide (CDIP-2) exerts anti-inflammatory activity via CCR1, CCR2 and CCR3 chemokine receptors: Implications as a potential therapeutic treatment of asthma. 2014.IntImmunopharmacol.Vol 20(1):1–11


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