Dr. Mario Díaz
Laboratory of Membrane Physiology and Biophysics

Department of Animal Biology

University of La Laguna, Spain



1990 Ph.D., Animal Physiology. La Laguna University, Spain

1989 B.Sc., Computer Sciences. Spanish Ministry of Science and Education

1886 M.Sc., Animal Biology. La Laguna University, Spain

1984 B.Sc., Biological Sciences. La Laguna University, Spain

Publications (selected)
  1. Marín R., Marrero-Alonso J., Fernández C., Cury D. and Díaz M. (2012). Estrogen receptors participate in multimolecular signalling complexes in lipid rafts. Relevance for neuroprotective actions. Frontiers in Biosciences. E4:1420-1433.
  2. Fabelo N., Martín V., González C., Alonso A. and Díaz M. (2012). Effects of estradiol on brain lipid and fatty acid composition. Comparison between pregnant and ovariectomized estradiol-treated rats. Journal of Neuroendocrinology. 24, 292–309.
  3. Boto A., Miguélez J., Marín R. and Díaz M. (2012). Synthesis of indolizidinone analogues of cytotoxic alkaloids: monocyclic precursors are also active. Bioorganic and Medicinal Chemical Letters. 22 : 3402–3407.
  4. Aso E., Lomoio S., López-Gonzalez I., Joda L., Carmona M., Fernández-Yagüe N., Moreno J., Juvés, S., Pujol A., Pamplona R., Portero-Otín M., Martín V., Diaz M. and Ferrer I. (2012). Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer disease. Brain Pathology. 22:636-653.
  5. Fabelo N., Martín V, Marín R., Santpere G, Aso E., Ferrer, I. and Díaz M. (2012). Evidence for premature “Lipid raft aging” in APP/PS1 double transgenic mice, a familial model of Alzheimer’s disease. Journal of Neuropathology and Experimental Neurology. 71(10):858-881.
  6. Lahoz F., Oton C., López D., Marrero-Alonso J., Boto A. and Díaz M. (2012). Whispering gallery mode laser based on antitumor drug-dye complex gain medium. Optics Letters. 37, 4756-4758.
  7. Díaz M., Fabelo N. and Marín R. (2012). Genotype-induced changes in biophysical properties of frontal cortex lipid raft from APP/PS1 transgenic mice. Frontiers in Physiology. 3:454.doi: 10.3389/fphys.2012.00454.
  8. Lahoz F., Oton C., López D., Marrero-Alonso J., Boto A. and Díaz M. (2013). High efficiency amplified spontaneous emission from a fluorescent anticancer drug–dye complex. Organic electronics. 14:1225-1230.
  9. Marín R., Rojo J.A., Fabelo, N., Fernández C. and Díaz M. (2013). Lipid raft disarrangement as a result of neuropathological progresses: A novel strategy for early diagnosis? Neuroscience. 245:26-39. DOI: 10.1016/j.neuroscience. 2013.04.025.
  10. Miguélez J., Boto A., Marín R. and Díaz M. (2013). Simplification of antitumoral phenanthroindolizidine alkaloids: short synthesis of cytotoxic indolizidinone and pyrrolidine analogues. European Journal of Medical Chemistry.66:540-554. DOI: 10.1016/j.ejmech.2013.06.009.
  11. González-Montelongo MC, Marín R., Pérez J.A., Gómez T. and Díaz M. (2013). Polyamines are the non-genomic transducers of androgen-induced calcium sensitization and contractile potentiation in intestinal smooth muscle. Molecular Endocrinology. 27: 1603-1616.Doi:10.1210/me.2013-1201.
  12. Marin R., Casañas V., Pérez J.A., Fabelo N., Fernández C.E. and Díaz M (2013) Oestrogens as modulators of neuronal signalosomes and brain lipid homeostasis related to protection against neurodegeneration. Journal of Neuroendocrinology.25:1104-1115.
  13. Lahoz F., López D., Díaz M., Marrero-Alonso J., Boto A. and Oton C. (2013). Optical gain and laser emission in fluorescent drug nanocomposites. IEEE Information Optics (WIO), 2013: 1-3. Doi:10.1109/WIO.2013.6601265.
  14. Marrero-Alonso J., Morales A., García-Marrero B., Boto A., Marín R., Cury D., Gómez T., Fernández-Pérez L., Lahoz F. and Díaz M. (2013). Unique SERM-like properties of the novel fluorescent tamoxifen derivative FLTX1. European Journal of Pharmaceutics and Biopharnaceutics. 85:898-910. DOI: 10.1016/j.ejpb.2013.04.024

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