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Biography

Dr. Miriam Benezra

Department of Radiology Radiochemistry & Imaging Science Service
Memorial Sloan Kettering Cancer Center, USA
Department of Radiology, Well Medical College of Cornell University, USA

Email: Benezram@mskcc.org


Qualifications


Ph.D., Hebrew University, Jerusalem, Israel, Cell Biology & Cancer
B.Pharm., Hebrew University, Jerusalem, Israel, Pharmacy license
M.Sc., Hebrew University, Jerusalem, Israel, Pharmacology
B.Sc., Hebrew University, Jerusalem, Israel, Biology


Publications (selected)

  1. Benezra M, Hambardzumyan D,  Penate-Medina,O  Veach DR. Pillarsetty. N, Smith  P, Zanzonico P, Longo VA, Holland  EC, Larson SM and Bradbury MS. F-dasatininb inhibits glioma cell proliferation and alters expression of PDGFR signaling pathway intermidiates in PDGFR-overexpressing glioma models, Neoplasia, 2012 December: 14(12): 1132-1143. doi 10.1593/neo.121750.
  2. Benezra M, Philips E, Tykera D, Dobrenkov K, Siim B, Chaplin D, Rafii  S, Rabbany S and Bradbury MS. Serial monitoring of human systemic xenograft models of leukemia using a novel vascular disrupting agent. Leukemia 2012 March: 26:1771-1778; doi; 10.138/leu.2012.48.
  3. Benezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, Burns A, DeStanchina E, Longo V, Herz E, Iyer S, Wolchok J, Larson SM, Wisner U, Bradbury MS. Multimodal silica nanoparticles as cancer targeted probes for clinical translation. J. Clin invit. 2011 July;121(7): 2768-2780. doi: 10.1172/JCI45600.
  4. Gilbert PM., Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Bourdreau NJ, Tsai KKC, Welm AL, Feldman MD, Weber BL, Weaver VM. HoxA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May;120(5):1535-1550. doi:10.1172/JCI39534.
  5. Schweppe RE, Klopper JP, Korch C, Pugazhenthi U, Benezra M, Knauf JA, Fagin JA, Marlow LA, Copland JA, Smallridge RC, Haugen BBRR. DNA profiling of 40 human thyroid cancer cell lines reveals cross-contaminations resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab. 2008 Nov;93(11):4331-41.
  6. Leboeuf R, Baumgartner JE, Benezra M, Malaguarnera R, Solit D, Pratilas CA, Rosen N, Knauf JA, Fagin JA. BRAF V600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase inhibition in thyroid cancer cell lines. J Clin Endocrinol Metab. 2008 Jun;93(6):2194-201.
  7. Benezra M*, Greenberg RS, Masur SK. Localization of ZO-1 in the nucleolus of corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 May;48(5):2043-9.
  8. Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK. FAK-dependent regulation of myofibroblast differentiation. FASEB J. 2006 May;20(7):1006-8. Epub 2006 Apr 3. Erratum in: FASEB J. 2006 Jul;20(9):1573.
  9. Taliana L, Benezra M, Greenberg RS, Masur SK, Bernstein AM. ZO-1: Lamellipodial localization in a corneal fibroblast wound model. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):96-103.
  10. Benezra M, Chevelair N, Morrison DJ, MacLachlan TK, El-Deiry WS, Licht JD. BRCA1 augments transcription by the NF-kB transcription factor by binding to the Rel homology domain of the p65/RelA subunit. J Biol Chem. 2003 Jul 18;278(29):26333-41.
  11. Benezra M*, Ishai-Michaeli R, Ben-Sasson S, Vlodavsky I. Structure  Activity Relation of heparin mimicking compounds in induction of bFGF release from extracellular matrix and inhibition of SMCs cell proliferation and heparin activity. J Cell Physiol. 2002 Sep;192(3):276-85.
  12. Gross I, Bassit B, Benezra M, Licht JD.  Functional characterization of mammalian sprouty 1 and sprouty 2, two members of a new family of receptor tyrosine kinase signaling inhibitors. J Biol Chem. 2001 Dec 7;276(49):46460-8.
  13. J Benezra M, Vogel T, Ben-Sasson S, Panet A, Sehayek E, AL-Haideri M, Decklbaum RJ, Vlodavsky I. A synthetic heparin-mimicking polyanionic compound inhibits vascular smooth muscle cell proliferation through binding  to the LDL receptor-related protein. J Cell Biochem. 2001 Apr;81(1):114-27.
  14. Houvras Y, Benezra M, Zhang H, Weber BL, Licht JD. BRCA1  physically and  functionally interacts with ATF1. J Biol Chem. 2000 Nov 17;275(46):36230-7.
  15. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, Ronai Z. Regulation of Signaling by GSTp. EMBO J. 1999 Mar 1;18(5):1321-34.
  16. Katz A, Vlodavsky I, Davies M, Ben-Sasson S, Darmon D, Horowitz H, Bor H, Benezra M. Antiproliferative activity to glomerular mesangial cells and receptor binding a heparin-mimicking polyaromatic anionic compound.  J Am Soc Nephrol. 1997 Nov;8(11):1688-97.
  17. Vlodavsky I, Hua-Quan M, Benezra M, Ishai-Michaeli R, Levy E, Bar-Shavit   R, Peretz T. Involvement of the extracellular matrix, heparan sulfate proteoglycans and heparan sulfate degrading enzymes in angiogenesis and metastasis. Tumor angiogenesis (ed. C.E. Lewis, R. Bicknell, N. Ferrara) Oxford University Press, Oxford, UK, 125-140, 1997.
  18. Benezra M, Ben-Sasson S, Regan J, Bar-Shavit R, Vlodavsky I. Antiproliferative activity towards vascular smooth muscle cells and receptor binding of heparin-mimicking anionic aromatic compounds.  Arterioscler Thromb. 1994 Dec;14(12):1992-9.
  19. Vlodavsky  I, Benezra M, Ishai-Michaeli R, Catane R, Ben-Sasson S. Control of tumor metastasis and angiogenesis by the extracellular matrix: Involvement of heparan sulfate and heparin-like molecules. Frontiers in cancer research (ed. A. Frensdorff) Ramot Publishing-Tel Aviv University, pp. 188-197, 1994.
  20. Benezra M, Vlodavsky I, Bar-Shavit R. Prothrombin is converted to thrombin by plasminogen activator residing in the subendothelial extracellular matrix. Semin Thromb Hemost. 1993;19(4):405-11.
  21. Benezra M, Vlodavsky I, Ishai-Michaeli R, Neufeld G, Bar-Shavit R. Thrombin induced release of active basic fibroblast growth factor heparan-sulfate complexes from subendothelial extracellular matrix. Blood 1993 Jun 15;81(12):3324-31.
  22. Benezra M, Vlodavsky I, Yayon A, Bar-Shavit R, Regan J, Chang M, Ben-Sasson S. Reversal of basic fibroblast growth factor-mediated autocrine cell transformation by aromatic anionic compounds. Cancer Res. 1992 Oct 15;52(20):5656-62.
  23. Benezra M, Vlodavsky I, Bar-Shavit R. Thrombin enhances degradation of heparan-sulfate in the extracellular matrix by tumor cell heparanase. Exp Cell Res.1992 Jul;201(1):208-15.
  24. Bar-Shavit R, Eskohjido Y, Benezra M, Vlodavsky I. Thrombin interaction with the vascular system. In: Biology of Vitronectins and their receptors (eds. K.T. Preissner, S. Rosenblatt, C. Kosf, J. Wegerhoff, and D.F. Mosher) Elsevier Science Publishers B.V., pp 209-216, 1993.
  25. Vlodavsky I, Eldor A, Ishai-Michaeli R, Korner G, Benezra M, Catane R, Bar-Shavit R.  Extracellular matrix-bound growth factors, enzymes and plasma proteins: Possible involvement in arteriosclerosis. Arteriosclerosis, (IX), 351-358, 1992.
  26. Bar-Shavit R, Benezra M, Sabbah V, Bode W, Vlodavsky I. Thrombin as a multifunctional protein:  Induction of cell adhesion and proliferation. American Journal of Respiratory Cell and Molecular Biology, (6):123-130, 1992.
  27. Bar-Shavit R, Benezra M, Sabbah V, Vlodavsky I, Dejana E and Wilner GD Functional domains in thrombin outside the catalytic site: Cellular interaction. In Thrombin Structure-Function. Plenum Publ., 315-350, 1992.

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