Dr. Pallav Patel

Department of Molecular Pharmacology and Chemistry

Memorial Sloan Kettering Cancer Center, USA



Ph.D., Pharmaceutical Sciences, St. John’s University & Memorial Sloan-Kettering Cancer Center (MSKCC)

M.Sc., Pharmaceutical Sciences, St. John’s University

B.Sc., Pharmacy, K.B. Institute of Pharmaceutical Education and Research (KBIPER)

Publications (selected)

  1. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Patel, P. D., Yan, P., Patel, H., Sun, W., Stephani, R., Gewirth, D., Chiosis, G. Nature Chem. Biol. , 2013, 9, 677-684.
  2. Experimental and structural testing module to analyze paralog-specificity and affinity in the Hsp90 inhibitors series. Taldone T, Patel, P. D., Patel, M. R., Patel, H. J., Gewirth, D., Chiosis, G. J. Med. Chem. 2013, 56, 6803-6818.
  3. Identification of an allosteric pocket on Hsp70 reveals a novel mode of inhibition of this therapeutically important protein. Rodina, A.*, Patel, P. D.*, Kang, Y.*; Taldone, T.; Patel, H.; Young, J.; Chiosis, G. Chemistry & Biology-Cell, 2013, 20, 1469-1480.
  4. Heat shock protein 70 inhibitors: 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Kang Y, Taldone T, Patel H, Patel P. D., Rodina A, Jason Y, Chiosis, G. J. Med. Chem. In Review, 2013.
  5. Heat shock protein 70 inhibitors: 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Taldone T, Kang Y, Patel H, Patel M, Patel P. D., Rodina A, Patel Y, Jason Y, Chiosis, G. J. Med. Chem. In Review, 2013.
  6. About the reaction of aryl fluorides with sodium sulfide.Taldone T, Patel, P. D., Patel. H. J., Chiosis, G. Tet. Lett. 2012, 53, 2548-2551.
  7. An efficient copper catalyzed microwave-assisted S-arylation towards the synthesis of 8-aryl-sulfanyl adenines. Sun W, Patel, P. D., Chiosis G. SynLett. 2011, 20, 3008-3012.
  8. Design, synthesis and evaluation of small molecule Hsp90 Probes. Taldone, T., Zatorska, D., Patel, P.D., Zong, H., Rodina, A., Ahn, J. H., Kamalika, M., Guzman, M. L., Chiosis, G. Bio. Org. Med. Chem. 2011, 19, 2603-2614.
  9. 3D QSAR Studies on Substituted Aryl Alkanoic acid Analogs as GPR40 Agonists. Bhatt, A., Patel, P. D., Patel, M. R., Singh, S., Talele, T. T. Chem. Biol. Drug. Des. 2011, 77, 361-372.
  10. Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90. Taldone, T., Gillan, V., Sun, W., Rodina, A., Patel, P., Maitland. K., O'Neill, K., Chiosis, G., Devaney, E. PLoS Negl. Trop. Dis. 2010, 4(6): e714.
  11. Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. Patel, P. D., Patel. M. R., Billack, B., Graham, S., Talele, T. T. E. J. Med. Chem. 2010, 45, 2214-2222.
  12. Synthesis and crystallographic characterization of a crucial intermediate for the synthesis of azole antifungal drugs. Patel, P. D., Talele, T. T., Fronczek, F. R., J. Chem. Crystallogr. 2009, 39, 923-926.
  13. 3D QSAR and Molecular Docking Studies of Benzimidazole Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors. Patel, P. D., Patel, M. R., Basu, N. K., Talele, T. T. J. Chem. Inf. Model. 2008, 48, 42-55.

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