Gokul C. Das
Department of Medicine/Nephrology
Baylor College of Medicine, USA
Ph.D., Calcutta University, India; Biophysics
M.S., Calcutta University, India;
Das, G. C. and Hollinger F. B. (2012),
Molecular pathways for glucose homeostasis, insulin signaling and autophagy in
hepatitis c virus induced insulin resistance in a cellular model, Virology 434,
5-17 (article selected for cover page and featured in Global Medical discovery
and in World Biomedical Frontiers)
Das, G. C. and Hollinger F. B. (2013)
Molecular pathways contributing to insulin resistance is active early in
infection but modified in persistently infected liver cells (Virology, in
Das G. C. Creighton, C, Sen P and
Hollinger, F. B. (2013) miRNA signatures in Hepatitis C Virus induced insulin
resistance: potential pathways and implication for miRNA-based therapy
(Manuscript In preparation)
Das, G. C, A. Basci, M. Sreevastava, Hazra,
T. and Boldogh I. (2006): Enhanced expression of Gamma-Glutamylcysteine
Synthetase activity decreases oxidative stress level and cytotoxicity. Mol
Carcinogenesis, 45, 635-647.
Vertrees RA, Das GC, Popov VL, Cosci AM,
Goodwin TJ, Logrono R, Zwischenberger JB, Boor PJ (2005) Synergystic
interaction of hyperthermia and gemcitabine in Lung Cancer. Cancer Biol Ther.
Vertrees RA, Das GC, Coscio, AM, Xie J,
Zwischenberger J B, Boor P J (2005) A mechanism of hyperthermia-induced
apoptosis in ras transformed lung cells. Mol Carcinog. 44, 111-121
Elliot, T., Das. G. C., Hammond, D., Jones,
L., Baker, T. L and Love J., (2005). Screening and identification of
cryopreservative agents for human cellular biotechnology experiments in
microgravity. Gavitational and Space Biology 18, 83.
Boldogh, I., Bhakat, K., Das, G. C.,
Bocangel, D. and Mitra S., (2004): Regulation of DNA repair and apoptosis by
p53 and its impact on alkylating drug resistance in tumor cells. In Cancer
Discovery and Development: DNA Repair in Cancer Therapy, Eds. Panci, LC and
Alaoui-Jamali, MA, The Human Press INC, Totowa, NJ, 2004.
Boldogh, I., Roy. G., Lee, M. S., Hazra,
T., Bhakat, K., Das, G. C. and Mitra, S. (2003), DNA double strand break
repair: down regulation by oxidative stress. Mol Toxicol. 193, 137-152.
Das, G. C., Gallardo, G. and Haas, C.,
2001: Taxol-induced cell cycle arrest and apoptosis: Dose-reponse relationship
in cells with different p. 53 status and under isogenic conditions. Cancer
Lett. 165, 147-153.
Lee, I. K., Lee, S., Das, G. C., Poo, H. R.
and Lee, Y. I., (2000): Activation of the insulin-like growth factor II
transcription by aflatoxin B1-induced p. 53 mutant 249 is caused by activation
of transcriptrion complexes; implications for a gain-of-function durinf
formation of hepatocellular carcinoma. Oncogene 19, 3717.
Das G. C., Gallardo R and Haas, C. (1999)
Modulation of apoptosis and cell cycle in a squamous cancer cell line with
mutant p. 53 under hypoxic conditions by taxol/mitomycin C/ metronidazole
combination. Proc. Am. Assoc. Cancer Res. 40, 484.
Das, G. C., Kriel, K., Gallardo, R. and
Haas, C. (1998) p. 53 status and paclitaxel sensitivity of lung cancer cells to
apoptosis. Proc. Am. Assoc. Cancer Res. 39, 162 (1998).
Shivakumar, C. V. and Das, G. C., (1998):
The A enhancer of Polyoma virus: protein-protein interactions for the
differential early and late promoter functions under non-replicating
conditions. Intervirology, 41, 103-109.
Shivakumar C. V. and Das, G. C., (1996): p.
53 binding and transactivation of human polyomavirus BK promoter. Oncogene 13,
Das, G. C., Shivakumar, C. V. and Sharon D.
Todd., 1995: Cell-specific regulation of the papovavirus promoters by
tumor-suppressor protein p53 in the absence of large T antigen. Oncogene 10,
Shivakumar, C. V. and Das, G. C., (1994):
Biochemical and mutational analysis of the polyomavirus core promoter:
Involvement of nuclear factor I in early promoter function. J. Gen. Virol. 75,
Das Gupta, S., Shivakumar, C. V. and Das,
G. C. (1993): Identification of proteins binding to the F441 locus of
polyomavirus B enhancer that are required for its activity in embryonic
carcinoma cells. J. Gen. Virol. 74, 597.
Roth, J. H., Das, G. C. and Piatigorsky,
J., (1991): Chicken BB1-Crystallin gene expression: Presence of conserved
functional polyoma virus enhancer-like and Octamer binding-like elements found
in non-lens genes. Mol. Cell. Biol. 11, 1488.
Chakraborty, T. and Das, G. C., (1991):
Proteins of the nuclear factor I family act as an activator of the late
promoter in human polyomavirus BK in vitro. J. Gen. Virology. 72, 1935.
Rangan, V. S. and Das, G. C., (1990):
Purification and biochemical characterization of hepatoctyte nuclear factor 2 (HNF-2)
involved in liver-specific transcription of the human alpha-1-antitrypsin gene.
J. Biol. Chem. 265, 8874.
Chakraborty, T. and Das, G. C., (1989):
Identificatin of Hela cell nuclear factors that bind to and activate the early
promoter of human polyoma virus BK in vitro. Mol. Cell. Biol. 9, 3821.
Das, G. C. and Piatigorsky, J., (1988):
Differential transcription of the two chicken delta-crystallin genes in vitro.
Current Eye Res. 7, 331.
Das, G. C. and Piatigorsky, J.
Transcription of the two delta-crystallin promoters in a Hela cell extract. In
Transcriptional control mechanisms, UCLA Symposia on Molecular and Cellular
Biology, New Series, Vol. 52, Eds. D.K. Granner, G. Rosenfield and S. Chang,
Alan R. Liss, Inc., New York, NY, p. 405-419, 1986.
Das, G. C. and Piatigorsky, J., (1986): The
chicken delta 1-Crystallin Promoter: Binding of transcription factors to the
upstream (G + C) - rich region is necessary for the promoter activity in vitro.
Proc. Natl. Acad. Sci, USA 83, 3131.
Last updated: 2014-3-4