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Biography

Dr. Jessy John Alexander

Department of Medicine,

The University of Chicago, USA

Associate Professor


Email: jalexand@medicine.bsd.uchicago.edu


Qualifications

1990   Ph.D., Biochemistry, University of Hyderabad, India

1982   M.Sc., Zoology, Osmania University, India

1980   B.Sc., Biology, Physics, Chemistry, Osmania University, India


Publications (Selected)

Books

  1. Chang A., P. Kadambi and J. J. Alexander. 2006. Membranoproliferative glomerulonephritis. Florian Lang (ed): Encyclopedic Reference of Molecular Mechanisms of Disease. Springer Verlag.
  2. Alexander, J. J., and R. J. Quigg. 2007. Systemic lupus erythematosus and the brain: What mice are telling us. Neurochem Int. 50: 5.
  3. Alexander, J. J., and R. J. Quigg. 2007. The simple design of complement factor H: Looks can be deceiving. Mol. Immunol. 44:123 (invited).
  4. Smith R.J., J. J. Alexander, P. N. Barlow, M. Botto, T. L. Cassavant, H. T. Cook, S. R. de Cordoba, G. S. Hageman, T. S. Jokiranta, W. J. Kimberling, J. D. Lambris, L. D. Lanning, V. Levidiotis, C. Licht, H. U. Lutz, S. Meri, M. C. Pickering, R. J. Quigg, A. L. Rops, D. J. Salant, S. Sethi, J. M. Thurman, H. F. Tully, S. P. Tully, J. van der Vlag, P. D. Walker, R. Wurzner and P. F. Zipfel; Dense Deposit Disease Focus Group.H 2007. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 18(9): 2447-56.
  5. Alexander, J .J., A. J. Anderson, S. R. Barnum, B. Stevens and A. J. Tenner. 2008. The Complement Cascade: Yin-yang in Neuroinflammation: Neuro-protection and -degeneration. J. Neurochemistry, Dec;107(5): 1169-87.

Journals

  1. Cunningham, P. N., V. M. Holers, J. J. Alexander, J. M. Guthridge, M. C. Carroll, and R. J. Quigg. 2000. Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure. Kidney Int. 58: 1580.
  2. Schiller, B., P. N. Cunningham, J. J. Alexander, L. Bao, V. M. Holers, and R. J. Quigg. 2001. Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure. J Am Soc Nephrol. 12: 71.
  3. Park, P., M. Haas, P. N. Cunningham, J. J. Alexander, L. Bao, J. M. Guthridge, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2001. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion. J Am Soc Nephrol. 12: 1383.
  4. Alexander, J. J., B. K. Hack, P. N. Cunningham, and R. J. Quigg. 2001. A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor. J Biol. Chem. 276: 32129.
  5. Park, P., M. Haas, P. N. Cunningham, J. J. Alexander, L. Bao, J. M. Guthridge, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2001. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion. J Am Soc Nephrol. 12: 1383.
  6. Park, P., M. Haas, P. N. Cunningham, L. Bao, J. J. Alexander, and R. J. Quigg. 2002. Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol 282: F352-F357.
  7. Bao, L., M. Haas, S. A. Boackle, D. M. Kraus, P. N. Cunningham, P. Park, J. J. Alexander, R. K. Anderson, K. Culhane, V. M. Holers, and R. J. Quigg. 2002. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol. 168: 3601.
  8. Ren, G., B. K. Hack, A. W. Minto, P. N. Cunningham, J. J. Alexander, M. Haas, and R. J. Quigg. 2002. A complement-dependent model of thrombotic thrombocytopenic purpura induced by antibodies reactive with endothelial cells. Clin. Immunol. 103: 43.
  9. Ren, G., M. Doshi, B. K. Hack, J. J. Alexander, and R. J. Quigg. 2002. Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. J Biol. Chem. 277: 48351.
  10. Alexander, J. J., A. K. Saxena, L. Bao, A. Jacob, M. Haas, and R. J. Quigg. 2002. Prominent renal expression of a murine leukemia retrovirus in experimental systemic lupus erythematosus. J Am Soc Nephrol. 13: 2869.
  11. Wyss-Coray, T., F. Yan, A. H. Lin, J. D. Lambris, J. J. Alexander, R. J. Quigg, and E. Masliah. 2002. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc. Natl. Acad. Sci. U. S. A 99: 10837.
  12. Ren, G., M. Doshi, B. K. Hack, J. J. Alexander, and R. J. Quigg. 2003. Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack. Kidney Int. 64: 914.
  13. Alexander, J. J., L. Bao, A. Jacob, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2003. Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta 1639: 169.
  14. Alexander, J. J., C. Zwingmann, and R. Quigg. 2005. MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int. 47:143.
  15. Alexander, J. J., M. C. Pickering, M. Haas, I. Osawe, and R. J. Quigg. 2005. Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness. J Am Soc Nephrol. 16: 52
  16. Alexander, J. J., A. Jacob, L. Bao, R. L. Macdonald, and R. J. Quigg. 2005. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol. 175: 8312.
  17. Alexander, J. J., O. G. Aneziokoro, A. Chang, B. K. Hack, A. Markaryan, A. Jacob, R. Luo, M. Thirman, M. Haas, and R. J. Quigg. 2006. Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease. J Am Soc Nephrol. 17: 1354.
  18. Wang, Y., J. Zhou, A. W. Minto, B. K. Hack, J. J. Alexander, M. Haas, Y. C. Li, C. W. Heilig, and R. J. Quigg. 2006. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int. 70: 882.
  19. Alexander, J. J., Y. Wang, A. Chang, M. Karmegam, A. Jacob, M. Haas, A. Minto and R. J.Quigg. 2007. Rodent factor H functions as a counterpart of human CR1 in renal immune complex processing. J Am Soc Nephrol. 18(4): 1157-66.
  20. Alexander, J. J., A. Jacob, P. Vezina, H. Sekine, G. S. Gilkeson, and R. J. Quigg. 2007. Absence of functional alternative complement pathway alleviates lupus cerebritis. European J. Immunology. 37(6): 1691-701.
  21. Alexander, J. J., C.  Zwingmann, A. Jacob and R. J. Quigg. 2007. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta (Molecular Basis of Disease). 1772(10): 1143-9.
  22. Jacob, A., L. Hensley, B. Safratowich, R. J. Quigg, and J. J. Alexander. 2007. The role of the complement cascade in endotoxin-induced septic encephalopathy. Lab Invest. 87(12): 1186-94.
  23. Alexander, J. J., A. Jacob, P. N. Cunningham, L. Hensley, and R. J. Quigg. 2008. TNF is a key mediator of Septic Encephalopathy acting through its receptor, TNF Receptor-1. Neurochem Int. 52(3): 447-56.
  24. Jacob, A., Brorson, J., Bao, L., R. J. Quigg, and J. J. Alexander. 2010. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus 19(1): 73-82.
  25. Jacob, A., Hack, B., Chiang, E., Garcia, J.G.N., R. J. Quigg, and J. J. Alexander. 2010. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J.  24(6): 1682-8.
  26. Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ.2010. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 221(1-2): 46-52.
  27. Alexander JJ, Hack BK, Jacob A, Chang A, Haas M, Finberg RW, Quigg RJ. 2010. Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. J Immunol. 185(6): 3759-67.
  28. Jacob A, Hack BK, Chen P, Quigg RJ, Alexander JJ. 2011. C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-κB. J Neurochem. 119(5): 1041-51.