Hee-Jeong Im Sampen

Departments of Biochemistry

Rush University Medical Center

Chicago, USA

Associate Professor



1992-1996 Ph.D., University of New South Wales, Biotechnolgy

1990-1991 M.S., University of New South Wales, Microbiology

Publications (Selected)

  1. Ping Su, Melissa L. Harvey, Hee-Jeong Im and Noel W. Dunn. 1997. Isolation and Characterisation of Abi I Gene from Lactococcus subsp. lactis M138 encoding abortive phage infection. J. Biotechnol. 54: 95-104. PMID: 9195753
  2. Ping Su, Hee-Jeong Im, H. Hsieh, S. Kang‟A and Noen W. Dunn. 1999. LIaFI, a type III restriction and modification system in Lactococcus lactis. Appl. Environ. Microbiol. 65(2): 686-693. PMID: 9925601
  3. Chung Y. Choe, Hee-Jeong Im, Jane L. Ko and Horace H. Loh. 1998. Mouse mu Opioid Receptor Gene Expression. A 34-base pair cis-acting element inhibits transcription of the mu opioid receptor gene from the distal promoter. J. Biol. Chem. 273 (52): 34926-34932. PMID: 9857022
  4. Hee-Jeong Im, Seong W. Kang and Horace H. Loh. 1999. Opioid Receptor gene: cytokine response element and the effect of cytokines. Brain Research 829: 174-179. PMID: 10350544
  5. Dmitri. Smirnov, Hee-Jeong Im and Horace .H. Loh. 2001. Delta-Opioid Receptor Gene: Effect of Sp1 factor on Transcriptional regulation in vivo. Mol. Pharmacology 60: 331-340. PMID: 11455020
  6. Hee-Jeong Im, Dmitri Smirnov, Tomoyaki Yuhi, Shalini.Raghavan, Jane E. Olsson, George E.O. Muscat, Peter, Koopman and Horace H. Loh. 2001. Transcriptional Modulation of mouse mu-opioid receptor distal promoter activity by Sox18 proteins. Mol. Pharmacology 59: 1486-1496. PMID: 11353810
  7. Hee-Jeong Im, Mark R. Pittelkow and Rajiv Kumar. 2002. The Divergent Regulation of the Growth Promoting Gene, IEX-1 by the Tumor Suppressor p53 and Sp1. J. Biol. Chem. 277(17): 14612-14621. PMID: 11844788
  8. Hee-Jeong Im, Mark R. Pittelkow and Rajiv Kumar. 2002. The Regulation of the IEX-1 Gene by 1alpha, 25-dihydroxyvitamin D3: Identification of a Vitamin D Response Element within the IEX-1 Gene. Oncogene 21(23): 3706-3714. PMID: 12032839
  9. Richard F. Loeser, Christopher Forsyth, Allen M. Samarel and Hee-Jeong Im. 2003. Fibronectin-fragment Activation of PYK-2 mediates integrin signals regulating Collagenase-3 expression by human chondrocytes through a PKC dependent pathway. J. Biol. Chem. 278(27): 24577-24585. PMID: 12730223
  10. Hee-Jeong Im, Carol Pacione, Susan Chubinskaya, Andre J. van Wijnen, Yubo Sun and Richard F. Loeser. 2003. Inhibitory effects of IGF-1 and OP-1 on fibronectin fragment- or IL-1beta-stimulated MMP-13 expression by human chondrocytes. J. Biol. Chem. 278(28), 25386-25394. PMID: 12734180
  11. Kumar R, Pittelkow MR, Salisbury JL, Grande JP, Hee-Jeong Im, Feldmann KA, Schilling D. 2003. A novel vitamin D- regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis. 2003. Recent Results Cancer Res. 164, 123-134. PMID: 12899517
  12. Rajiv Kumar, Ward Lutz, Elena Frank and Hee-Jeong Im. 2004. Immediate Early Gene X-1 interacts with proteins that modulate apoptosis. Biochem. Biophy. Res. Comm. 323, 1293-1298. PMID: 15451437
  13. Ohno Shigeru, Hee-Jeong Im, Cheryl B. Knudson, Warren Kundson. 2005. Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes. Arthritis Rheum 52, 800-809. PMID: 15751080
  14. Mario Galindo, Jitesh Pratap , Daniel W. Young, Hayk Hovhannisyan , Hee-Jeong Im, Je-Yong Choi, Janet L. Stein, Jane B. Lian, Gary S. Stein and Andre J. van Wijnen. 2005. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1 related anti-proliferative function in osteoblasts. J. Biol. Chem. 280(21), 20274-20285. PMID: 15781466
  15. Pulai JI, Chen H, Hee-Jeong Im, Kumar S, Hanning C, Loeser RF. 2005. NFkB mediates the stimulation of cytokine and chemokine expression by Human articular chondrocytes in response to fibronectin fragments. J. Immunol. 174(9), 5781-5788. PMID: 15843581, NIHMSID: 211559
  16. Loeser RF, Yammani R, Carlson CS, Chen H, Cole A, Hee-Jeong Im, Bursch LS, Yan DS. 2005. Articular chondrocytes express the receptor for advanced glycation end products (RAGE): potential role in osteoarthritis. Arthritis Rheum. 52(8), 2376-2385. PMID: 16052547
  17. Forsyth CB, Cole A, Murphy G, Bienias JL, Im Hee-Jeong, Loeser RF. 2005. Increased MMP-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J. Gerontol. A. Biol. Sci. Med. Sci. 60, 1118-1124. PMID: 16183949
  18. Guoguang Yang, Hee-Jeong Im, James H-C Wang. 2005. Repetitive mechanical stretching modulates IL-1β induced COX-2 expression and PGE2 production in human patellar tendon fibroblasts. GENE 363, 166-172. PMID: 16226404, NIHMSID: 215122
  19. Richard F Loeser Carol Pacione, Susan Chubinskaya, Hee-Jeong Im 2005. Basic fibroblast growth factor inhibits anabolic effects mediated by the combination of insulin-like growth factor-1 (IGF-1) and osteogenic protein-1 (OP-1) in human articular chondrocytes. Arthritis Rheum 52, 3910-3917. PMID: 16320338
  20. Bhavani P Thampatty, Hee-Jeong Im, James H-C. Wang. 2006. Leukotriene B4 at low dosage negates the catabolic effect of PGE2 in human patellar tendon fibroblasts: An in vitro study. GENE 372, 103-109. PMID: 16488093