Dr. Michael J. Palladino
Dr. Michael J. Palladino

Department of Pharmacology & Chemical Biology

University of Pittsburgh, USA

Associate Professor



2000 Ph.D., University of CT Health Center, Biomedical Science

1997 B.S., Trinity College, Biology

Publications (Selected)

  1. Stacy L Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino (2013). Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency. Neurobiol Dis. 2013 Jan 12. doi: pii: S0969-9961(13)00011-9.
  2. Liu, Zhaohui, Alicia M. Celotto, Guillermo Romero, Peter Wipf, Michael J. Palladino (2012). Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. Neurobiology of Disease, 45 (1): 362-8. PMCID: PMC3225579.
  3. Celotto, Alicia M., Zhaohui Liu, Andrew P. VanDemark, and Michael J. Palladino (2012). A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease. Brain and Behavior, 2 (4): 423-34. PMCID: PMC3432965.
  4. Celotto AM, W.K. Chiu, W. Van Voorhies, Michael J. Palladino (2011). Modes of Metabolic Compensation during Mitochondrial Disease Using the Drosophila Model of ATP6 Dysfunction. PLoS ONE 6 (10): e25823. PMCID: PMC3185040
  5. Palladino, Michael J (2010). Modeling mitochondrial encephalomyopathy in Drosophila. Neurobiology of Disease, 40 (1); 40-45. PMCID: PMC2926304.
  6. Hrizo, Stacy L., and Michael J. Palladino (2010). Hsp70 and Hsp90 mediate proteasomal degradation of TPIsugarkill that underlies pathogenesis. Neurobiology of Disease, 40 (3); 676-83. PMCID: PMC2955819.
  7. Burton, Edward A. and Michael J. Palladino (2010). Of fish, flies, worms and men: powerful approaches to neuropsychiatric disease using genetic models. Neurobiology of Disease, Editorial. 40(1); 1-3. PMCID: PMC2948676.
  8. Ashmore, Lesley J., Stacy L. Hrizo, Sarah M. Paul, Wayne Van Voorhies, Greg J. Beitel, and Michael J. Palladino (2009). Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity. Human Genetics 126(3): 431-447. PMCID: PMC2791699.
  9. Seigle, Jacquelyn L., Alicia M. Celotto, and Michael J. Palladino (2008). Degradation of functional TPI protein underlies sugarkill neuropathology. GENETICS 179, 855-862. PMCID: PMC2429879.
  10. Langhans, Mark T. and Michael J. Palladino (2008). Cleavage of mispaired heteroduplex DNA substrates by numerous restriction enzymes. Current Issues in Molecular Biology 11, 1-12. PMCID: PMC2670344.
  11. Paul, Sarah M., Michael J. Palladino, and Greg. J. Beitel (2007). A pump-independent function of the Na, K-ATPase is required for epithelial junction function and tracheal tube-size control. Development 134, 147-55. PMCID: PMC1955469.
  12. Fergestad, Tim, Lisa Olson, Khelan P. Patel, Rosie Miller, Michael J. Palladino, and Barry Ganetzky (2007). Neuropathology in Drosophila Mutants With Increased Seizure Susceptibility. GENETICS 178, 947-956. PMCID: PMC2248337.
  13. Fergestad, Tim, Barry Ganetzky and Michael J. Palladino (2006). Neuropathology Drosophila Membrane Excitability Mutants. GENETICS 172, 1031-1042. PMCID: PMC1456203.
  14. Celotto, Alicia M., Adam C. Frank, Steven W. McGrath, Timothy J. Fergestad, Wayne A. Van Voorhies, Karolyn Buttle, Carmen A. Mannella and Michael J. Palladino (2006). Mitochondrial Encephalomyopathies in Drosophila. Journal of Neuroscience 26, 810-820.
  15. Celotto, Alicia M., Adam C. Frank, Jacquelyn L. Seigle, Michael J. Palladino (2006). Drosophila model of human inherited TPI deficiency glycolytic enzymopathy. GENETICS 174, 1237-1246. PMCID: PMC1667072.
  16. Bayir, H., Fadeel, B., Palladino, M. J., Witasp, E., Kurnikov, I. V., Tyurina, Y. Y., Tyurin, V. A., Amoscato, A. A., Jiang, J., Kochanek, P. M., et al. (2006). Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta. 1757, 648-59.
  17. Celotto, Alicia M. and Michael J. Palladino (2005). Drosophila, a “model” model system to study neurodegeneration. Mol. Interv. 5, 292-303.
  18. Palladino, Michael J., Jill E. Bower, Robert Kreber and Barry Ganetzky (2003). Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. Journal of Neuroscience 23, 1276-86.
  19. Harris, David, Charisse Orme, Joseph Kramer, Luria Namba, Mia Champion, Michael J. Palladino, Jeanette Natzle, and R. Scott Hawley (2003). A deficiency screen of the major autosomes identifies a single gene (CG18543, renamed matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila Oocytes. GENETICS 165, 637-652. PMCID: PMC1462769.
  20. Palladino, Michael J., Tricia J. Hadley, and Barry Ganetzky (2002). Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila. GENETICS 161, 1197-1208. PMCID: PMC1462168.
  21. Hanrahan, Christopher J., Michael J. Palladino, Barry Ganetzky and Robert A. Reenan (2000). RNA editing of the para sodium channel transcripts. GENETICS 155, 1149-1160. PMCID: PMC1461140.
  22. Palladino, Michael J., Liam P. Keegan, Mary A. O’Connell and Robert A. Reenan (2000). Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA 6, 1004-1018. PMCID: PMC1369976.
  23. Palladino, Michael J., Liam P. Keegan, Mary A. O’Connell and Robert A. Reenan (2000). A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102, 437-449.
  24. Hanrahan, Christopher J., Michael J. Palladino, Laurie J. Bonneau,, and Robert A. Reenan (1999). RNA editing of a Drosophila sodium channel gene. Annals of the New York Academy of Sciences 868, 51-66.
  25. Oswald, Christine, Peter Fonken, Dana Atkinson and Michael J. Palladino (1993). Lactational water balance and recycling in white-footed mice, red-backed voles and gerbils. Journal of Mammalogy 74 (4), 963-970.