Dr. Derong Ding

Department of Chemistry and Biochemistry

University of Notre Dame, USA

Research Scientist



2005 Ph.D., Organic Chemistry, Chinese Academy of Sciences, China

Publications (selected)
  1. Erika Leemans, Kiran V. Mahasenan, Malika Kumarasiri, Edward Spink , Derong Ding, Peter I. O’Daniel, Marc A. Boudreau , Elena Lastochkin , Sebastian A. Testero, Takao Yamaguchi , Mijoon Lee, Dusan Hesek , Jed Fisher, Mayland Chang*, Shahriar Mobashery*. Three-dimensional QSAR analysis and design of new 1, 2, 4-oxadiazole antibecterials. Bioorg. Med. Chem. Lett. 2016, 26, 1011-1015
  2. Derong Ding, Marc A. Boudreau, Erika Leemans, Edward Spink, Takao Yamaguchi, Sebastian A. Testero, Peter I. O’Daniel, Elena Lastochkin, Mayland Chang*, Shahriar Mobashery*. Exploration of the structure-activity relationship of 1, 2, 4-oxadiazole antibiotics. Bioorg. Med. Chem. Lett. 2015, 25, 4854-4857
  3. Edward Spin$, Derong Ding$, Zhihong Peng, Marc A. Boudreau, Erika Leemans, Elena Lastochkin, Wei Song, Katerina Lichtenwalter, Peter I. O’Daniel, Sebastian A. Testero, Hualiang Pi, Valerie A. Schroeder, William R. Wolter, Nuno T. Antunes, Mark A. Suckow, Sergei Vakulenko, Mayland Chang*, and Shahriar Mobashery* . Structure-activity relationship for the oxadiazole class of antibiotics. J. Med. Chem. 2015, 58, 1380–1389. ($ Co-first authors)
  4. Derong Ding, Justin R. Nickell, Linda P. Dwoskin, Peter A.Crooks*. Quinolyl analogues of norlobelane: novel potent inhibitors of vesicular [3H]dihydrotetrabenazine binding and [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg. Med. Chem. Lett. 2015, 25, 2613-2616
  5. Peter I. O’Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lashtochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery,* and Mayland Chang*. Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. J. Am. Chem. Soc. 2014, 136 , 3664-3672
  6. Derong Ding, Katerina Lichtenwalter, Hualiang Pi, Shahriar Mobashery* and Mayland Chang*. Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8). Med. Chem. Commun. 2014, 5, 1381-1383
  7. Major Gooyit, Zhihong Peng, William R. Wolter, Hualiang Ping, Derong Ding, Dusan Hesek, Mijoon Lee, Bill Boggess, Matthew M. Champion, Mark A. Suckow, Shahriar Mobashery*, and Mayland Chang*. A chemical biological strategy to facilitate diabetic wound healing. ACS Chem. Biol. 2014, 9,105–110
  8. Derong Ding, Justin R. Nickell, Agripina G. Deaciuc, Narsimha Reddy Penthala, Linda P. Dwoskin, Peter A. Crooks*. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorg.Med.Chem. 2013, 21, 6771-6777
  9. Derong Ding, Linda P. Dwoskin, Peter A Crooks*. Efficient synthesis of cis-2, 6-di-(2-quinolylpiperidine). Tetrahedron Lett. 2013,54, 5211-5213
  10. Qi Zhang$, Derong Ding$, Shelya X Zeng, Qi-Zhuang Ye *, Hua Lu*. Structure and activity analysis of Inauhzin analogs as novel antitumor compounds that induce p53 and inhibit cell growth. PLoS ONE 2012, 7, e46294 ($ Co-first authors)
  11. Qi Zhang, Shelya X Zeng, Yu Zhang, Yiwei Zhang , Derong Ding, Qi-Zhuang Ye, Samy O. Meroueh and Hua Lu* . A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumor growth through activation of p53. EMBO Mol. Med. 2012 ,4, 298-312
  12. Derong Ding, Guang Yan*. A convenient method for the synthesis of aminomethyl monoalkylphosphinate. Chin. J. Chem. 2012, 30, 1906-1908
  13. Derong Ding , Baozi Zhang, Tao Meng, Ying Ma, Xin Wang, Hongli Peng and Jingkang Shen*. Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells. Org. Biomol. Chem. 2011, 9, 7287–7291
  14. Sheng-chang Xiang, Zhangjing Zhang, Cong-Gui Zhao, Kunlun Hong, Xuebo Zhao, De-Rong Ding, Ming-Hua Xie, Chuan-De Wu, Madhab C. Das, Rachel Gill, K. Mark Thomas*, Banglin Chen* . Rationally tuned micropores within enantiopure metal-organic frameworks for highly selective separation of acetylene and ethylene. Nat. Commun. 2011, 2, 204
  15. Sergio C. Chai, Wen-Long Wang, De-Rong Ding, Qi-Zhuang Ye*. Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase. Eur. J. Med. Chem. 2011, 46, 3537-3540.
  16. Derong Ding, Cong-gui Zhao*. Organocatalyzed synthesis of 2- amino -8 -oxo-5,6,7,8 –tetrahydro -4H -chromene-3-carbonitriles. Tetrahedron Lett. 2010, 51, 1322 -1325
  17. Derong Ding, Cong-gui Zhao*, Qunsheng Guo, Hadi Arman. Enantioselective synthesis of bicylco[3.2.1]octan-8-ones using a tandem Michael-Henry reaction. Tetrahedron 2010, 66, 4423-4427
  18. Derong Ding, Cong-gui Zhao*. Primary amine catalyzed Biginelli reaction for the enantioselective synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Eur. J. Org. Chem. 2010, 3802-3805
  19. Sanjib Gogoi, Cong-gui Zhao*, and Derong Ding. Enantioselective synthesis of -(3-Hydroxypyrazol-1-yl) ketones using an organocatalyzed Micheal addition reaction. Org. Lett. 2009, 11, 2249-2252.
  20. Weiqing Xie, Derong Ding, Weiwei Zi, Guangyu Li, and Dawei Ma*. Total synthesis and structure assignment of Paupuamide B, a potent marine cyclodepsipeptide with anti-HIV properties. Angew. Chem. Int. Ed. 2008,47, 2844-2848
  21. Derong Ding, Xin Li, Xin Wang, Yongli Du and Jingkang Shen*. Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones. Tetrahedron Lett. 2006, 47, 6997-6999.
  22. Ding Derong, Jingkang Shen*. Current status of studies on acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors. Chinese Journal of New Drugs 2005,14,396-400
  23. Naresh Ramireddy, Santhi Abbaraju, Derong Ding, Hadi Arman, and John C.-G. Zhao*. Organocatalyzed enantioselective synthesis of 2-amino-4H-chrormene derivatives. J. Heterocyclic. Chem. (Under review)
  24. Marc A. Boudreau, Derong Ding, Edward Spink, Takao Yamaguchi, Sebastian A. Testero, Peter I. O’Daniel, Erika Leemans, Elena Lastochkin, Valerie A. Schroeder, William R. Wolter, Mark A. Suckow , Mayland Chang*, Shahriar Mobashery*. Structure-activity relationship for the ring D of the oxadiazole class of antibiotics II. J. Med. Chem. (manuscript)
  25. Renee Bouley, Derong Ding, Zhihong Peng, Wei Song, Elena Lastochkin, Valerie A. Schroeder, William R. Wolter, Hualiang Pi, Nuno T. Antunes, Mark A. Suckow, Sergei Vakulenko, Mayland Chang*, Shahriar Mobashery*.Exploration of a structure-activity relationship for the 4(3H)-quinazolinone antibiotics. J. Med. Chem. (manuscript)