Prof. Andrei Surguchov

VA Medical Center and Kansas University Medical Center

Research Biologist



1976 Ph.D., Cardiology Research Center, Molecular Biology

1970 M.S., Moscow State University, Molecular Biology

1968 B.S., Moscow State University, Biochemistry

Publications (selected)

  1. Pronin AN, Morris AJ, Surguchov A, Benovic JL. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem. 2000, 275, 26515-26522
  2. A. Surguchov, B. McMahon, E. Masliah, I. Surgucheva. Synucleins in ocular tissues. 2001, J Neurosci Res, 65, 68-77
  3. A. Surguchov, RE. Palazzo, and I. Surgucheva. Gamma synucleins: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction. Cell Motility and Cytoskeleton, 2001, 49, 218-228
  4. Surgucheva I., McMahan B, F. Ahmed, Tomarev S, Wax MB, Surguchov A. 2002. Synucleins in glaucoma. J Neurosci Res, 68: 97-106.
  5. Surgucheva I, Sivak, JM, Fini ME, Palazzo RE and Surguchov AP. 2003. Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 410: 167-176.
  6. Maurage CA, Ruchoux MM, De Vos R, Surguchov A, Destee A. 2003. Retinal involvement in dementia with Lewy bodies: A clue to hallucinations? Ann Neurol. 54(4): 542-7.
  7. Snyder HM, Mensah K, Surgucheva I, Festoff B, Surguchov A, Wolozin B. Synuclein prevents Proteasomal inhibition by α-synuclein but not γ-synuclein. J Biol Chem, 2005. 4; 280: 7562-9.
  8. Surgucheva, B. Yue, BC Park, S Tomarev and A. Surguchov. 2005. Interaction of myocilin with gamma- synuclein and its role in neurodegeneration in glaucoma. Cellular Molecular Neurobiology, 25 ,6, 1009-1033.
  9. Surgucheva I, Ninkina N, Buchman VL, Grasing K, A. Surguchov. 2005. Protein aggregation in retinal cells and approaches to cell protection. Cellular Molecular Neurobiology, 25, 6, 1051-1066. PMID: 16392036
  10. A. Surguchov. 2008. Molecular and cellular biology of synucleins. International Review of Cell and Molecular Biology, 270, 225-317. PMID: 19081538
  11. A. Surguchev and A. Surguchov. 2010. Conformational Diseases: Looking into the eyes. Brain Research Bulletin, 81, pp. 12-24. PMID: 19808079
  12. Surgucheva I, Chidambaram K, Willoughby DA, Surguchov A. MicroRNA regulates MMP-9 expression. J Ocular Biology, Diseases and Bioinformatics 2010; 3: 41-52, PMID: 21818406
  13. Surgucheva I, McMahon B, Surguchov A. Patterns of synuclein expression throughout lens development. J Biophys Chem 2010;1:12-18. DOI: 10.4236/jbpc.2010.11002
  14. Surguchov A. in “Protein Aggregation” (Editor: Douglas A. Stein). Folding and unfolding of Synucleins, Nova Science Publishers, 2011. ISBN: 978-1-61761-815-4
  15. Surgucheva I and Surguchov A. Expression of caveolins in trabecular meshwork cells and its possible implication in pathogenesis of primary open angle glaucoma. Molecular Vision 2011; 17: 2878-2888. PMID: 22128235
  16. Surgucheva I, Sharov VS, Surguchov A. γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells. Biochemistry. 2012, 51 (23): 4743-54.
  17. Surguchov A. Synucleins : Are they two edged swords? J Neurosci Res, 2012

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