Dr. Yu Chen

Dr. Chen Yu

The Hong Kong University of Science and Technology, Hong Kong, China

Research Assistant Professor



2011-present Adjunct Associate Professor, Jinan University, Guangzhou, China

2010-present Research Assistant Professor, HKUST

2007-2010 Research Associate/Visiting Scholar, HKUST

2003-2007 Ph.D., The Hong Kong University of Science and Technology (HKUST), Hong Kong, China

1998-2002 B.Sc., Sun Yat-Sen (Zhongshan) University, Guangzhou, China

Publications (Selected)

  1. Yu Chen, Amy K.Y. Fu and Nancy Y. Ip. (2013) Axin: an emerging key scaffold at the synapse. IUBMB Life 65(8): 685-91.
  2. Yu Chen, Wing-Yu Fu, Jacque P.K. Ip, Tao Ye, Amy K.Y. Fu, Moses. V. Chao and Nancy Y. Ip (2012) ARMS/Kidins220 is required for neurotrophin and ephrin receptor-dependent dendrite development. Journal of Neuroscience 32(24): 8263-9.
  3. Yu Chen, Amy K.Y. Fu and Nancy Y. Ip. (2012) Eph receptors at synapses: implications in neurodegenerative diseases. Cellular Signalling 24(3): 606-11.
  4. Jacque P. K. Ip, Lei Shi, Yu Chen, Yasuhiro Itoh, Wing-Yu Fu, Andrea Betz, Wing-Ho Yung, Yukiko Gotoh, Amy K.Y. Fu and Nancy Y. Ip (2012) 2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nature Neuroscience 15(1): 39-47.
  5. Wei-Qun Fang, Jacque P.K. Ip, Rui Li, Yu-Pong Ng, Sheng-Cai Lin, Yu Chen, Amy K.Y. Fu, and Nancy Y. Ip (2011) Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. Journal of Neuroscience 31(38): 13613-24.
  6. Hovik Farghaian, Yu Chen, Ada W.Y. Fu, Amy K.Y. Fu, Jacque P.K. Ip, Nancy Y. Ip, Ann M. Turnley and Adam R. Cole. (2011) Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm. Journal of Biological Chemistry 286(22): 19724-34.
  7. Amy K Fu, Kwok-Wang Hung, Wing-Yu Fu, Chong Shen, Yu Chen, Jun Xia, Kwok-On Lai and Nancy Y. Ip. (2011) APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nature Neuroscience 14(2): 181-9.
  8. Peng Zhang, Pei-Chun Yu, Anthony H. K. Tsang, Yu Chen, Amy K. Y. Fu, Wing-Yu Fu, Kenny K. Chung and Nancy Y. Ip. (2010) S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development. Journal of Neuroscience 30(43): 14366-70.
  9. Yu Chen* and Wing-Yu Fu*. (2009) EphB maintains dendritic spine morphology through focal adhesion kinase. Journal of Neuroscience 29(42): 13091-3 (* equal contribution and corresponding author).
  10. Yu Chen, Amy K Y Fu and Nancy Y Ip. (2009) Bidirectional signaling of ErbB and Eph receptors at synapses. Neuron Glia Biology 4(3): 211-21.
  11. Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng and Nancy Y Ip. (2007). Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biology 5(4): e63.
  12. 12. Wing-Yu Fu*, Yu Chen*, Mustafa Sahin, Xiao-Su Zhao, Lei Shi, Jay B Bikoff, Kwok-On Lai, Wing-Ho Yung, Amy K Y Fu, Michael E Greenberg and Nancy Y Ip. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nature Neuroscience 10(1): 67-76. (*equal contribution).
  13. Shuo Luo*, Yu Chen*, Kwok-On Lai, Juan Carlos Arévalo, Stanley C Froehner, Marvin E Adams, Moses V Chao and Nancy Y Ip. (2005) α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. Journal of Cell Biology 169(5): 813-24. (*equal contribution).
  14. Kwok-On Lai, Yu Chen, Hoi-Man Po, Ka-Chun Lok, Ke Gong and Nancy Y Ip. (2004) Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression. Journal of Biological Chemistry 279(14): 13383-92.

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