Dr. Linan Chen

Department of Neurobiology

The University of Chicago, USA
Research Assistant Professor



1997-2000 Ph.D., Medical School of Peking University, Neurobiology

1994-1997 M.Sc., Capital University of Medical Sciences, Neuroanatomy

1989-1994 B.Sc., Shandong Medical University, Clinical Medicine

Publications (selected)

  1. Xie Z., Zhuang X., Chen L.* (*Corresponding author) (2009) DJ-1 mRNA anatomical localization and cell type identification in the mouse brain. Neurosci Lett. 2009 Nov 20; 465(3): 214-9
  2. Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, Xia K, Jiang W, Ronai Z, Zhuang X, Zhang Z. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest. 2009 Mar; 119(3): 650-60
  3. Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. (2008) Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am J Respir Crit Care Med. 2008 Sep 15; 178(6): 592-604.
  4. Chen L.* (*Corresponding author), Ding Y., Cagniard B., Van Laar A.D., Mortimer A., Chi W., Hastings T., Kang U.J. & Zhuang X. (2008) Unregulated increase of cytosolic dopamine causes neurodegeneration in mice. J Neurosci. Jan 9; 28(2): 425-33 (Featured in “This Week in The Journal”)
  5. Yang W*, Chen L* (*Equal contribution), Ding Y, Zhuang X, and Kang UJ (2007) Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum Mol Genet. Dec 1; 16(23): 2900-10. Epub 2007 Sep 6.
  6. Chen L, Cagniard B, Mathews T, Jones S, Koh HC, Ding Y, Carvey PM, Ling Z, Kang UJ, Zhuang X. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 280: 21418-21426
  7. Chen Q, Duan D, Yang H, Sun C, Chen L, Xu Q. (2005) The expression efficiency of the transgene, tyrosine hydroxylase, mediated by plasmid and retrovirus in primary fibroblasts and glial cells of the rat. Acta of Anatomica Sinica 36: 76-80
  8. Chen L. & Zhuang X. (2003) Transgenic mouse models of dopamine deficiency. Ann Neurol, 54:S91–S102. (Review)
  9. Fan Y, Cui F, Chen L (2002). Adhesion of neural cells on silicon wafer with nano-topographic surface. Applied Surface Science 187: 313-318
  10. Fan YW, Cui FZ, Hou SP, Xu QY, Chen L, Lee IS (2002) Culture of neural cells on silicon wafers with nano-scale surface topograph. J Neurosci Methods 120(1): 17-23.
  11. Chen L, Sun C, Chen Q, Duan D, Yang H & Xu Q (2002) Cloning, purification and function assay of epitope tagged GFRa-1. Acta of Anatomica Sinica 33 (2): 257-261
  12. Chen L, Xu Q & Lu J (2001) The study of factors affecting primary culture of dopaminergic neurons in rat fetus. Acta of Anatomica Sinica. 31: 307-312
  13. Wang W, Chen L, Gao X. (2000) High Efficient Transfection of COS-7 by Electroporation. Guangdong Neuroanatomy Newsletter. 15: 122-25
  14. Qin L, Chen L, Xu Q, Yu E (2000) The role of mGluRs in the function of basal ganglia. Chinese Journal Of Neuroanatomy 16(1): 91-92 (Review)
  15. Fan Y, Cui F, Chen L (2000). Improvement of neural cell adherence to silicon surface by hydroxyl ion implantation. Surface Coating Technology. 131: 355-359
  16. Yu F, Duan D, Jiang C, Chen L, Qin L(2000), The expression and activity of Newly-cloned human basic fibrablast growth factor gene in COS-7 cell. Acta of Anatomica Sinica. 30: 225-231
  17. Chen L & Xu Q (2000) Three-dimensional reconstruction and comparative study on human and rat basal ganglia. Chinese Journal of Neuroanatomy 16(3): 217-221

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