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Biography
Prof. Arun Seth

Prof. Arun Seth

Sunnybrook Health Sciences Centre, Cananda


E-mail: arun.seth@utoronto.ca


Qualifications


1981    PhD, Molecular Biology, University of New Brunswick, Canada

1975    MS, Organic Chemistry, Meerut University, India


Publications (Selected)

  1. Seth, A and Jay E: A study of the efficiency and problem of sulfonation of several condensing reagents and their mechanisms for the chemical synthesis of deoxyoligoribonucleotides. Nucleic Acids Res. 8:5445-5459, 1980.
  2. Jay, E, Seth, A and Jay, G.: Specific binding of a chemically-synthesized ribosome recognition site-prospect for molecular cloning and expression of eukaryotic genes. J Biol. Chem. 255:3809-3812, 1980.
  3. Jay, G., Khoury, G, Seth, A. and Jay, E.: Construction of a general vector for efficient expression of mammalian proteins in bacteria: Use of a synthetic ribosome binding site. Proc. Natl. Acad Sci.USA 78:5543-5548, 1981.
  4. Young, TS, Modrich, P, Seth, A, Jay, E and Kim, SH : Preliminary X-ray diffraction studies of EcoRI restriction endo-nuclease-DNA complex. J. Mol. Biol. 145:607-610, 1981.
  5. Jay, E, Seth, A, Rommens, J, Sood, A and Jay, G: Gene expression Chemical synthesis of E. coli ribosome binding sites and their use in directing the expression of mammalian proteins in bacteria. Nucleic Acids Res. 10:6319-6329, 1982.
  6. Seth, A: A new method for linker ligation. Gene Anal. Techn 1:99 – 103, 1984
  7. Seth, A and Vande Woude, GF: High-level expression of v-mos protein of Moloney murine sarcoma virus in E. coli. In Whelan, W.J. and Schultz, J. (Eds): Advances in Gene Technology: Human Genetic Disorders. Cambridge, Cambridge University Press, p.240.
  8. Lautenberger, SA, Seth, A, Jorcyk, C and Papas, TS: Useful modification of the Escherichia coli expression plasmid pJL6. Gene Anal. Techn. 1:63-69, 1984.
  9. Seth, A: Linker ligation. Trends Genet. 1:195, 1985.
  10. Seth, A and Vande Woude, GF: Nucleotide sequences and the biochemical activities of the HT1MSV mos gene. J Virol.  56:144-152, 1985.
  11. Seth, A, Lapis, P, Vande Woude, GF and Papas, TS: High-level expression vectors to synthesize infused proteins in Escherichia coli. Gene 42:49-57, 1986
  12. Blair, DG, Oskarsson, MK, Seth, A., Dunn, KJ, Dean, M, Zwig, M, Tainsky, MA and Vande Woude, GF: Analysis of the transforming potential of the human homology of mos. Cell 46:785-794, 1986.
  13. Ascione, R, Sacchi, N, Watson, DK, Fisher, RJ, Fujiwara, S, Seth, A.,and Papas, TS: Oncogenes: Molecular probes for clinical application in malignant diseases: Gene Anal. Techn 3:25-39, 1986.
  14. Seth, A., Priel, E and Vande Woude, GF: Nucleoside triphosphate-dependent nucleic acid-binding properties of mos protein. Proc. Natl. Acad. Sci. USA 84:3560-3564, 1987.
  15. Li, C_C H, Shah, DV, Seth, A and Gilden, RV: Identification of the human papillomavirus-6b L1 open reading frame protein in condylomas and corresponding antibodies in human sera. J Virol. 61:2684-2690, 1987.
  16. Samuel KP, Seth, A, Konopka, A, Lautenberger, JA and Papas, TS: The 3’-ORF protein  of human immunodeficiency virus shows structural homology with the phosphorylation domain of human interleukin-2 receptor and the ATP-binding site of the protein kinase family. FEBS Letters 218:81-86, 1987.
  17. Gonzatti-Haces, M, Seth, A, Park, M, Copeland, T, Croszlan, S and Vande Woude, GF: Characterization of the tpr-met oncogene p65 and the met proto-oncogene cell surface p140 tyrosine kinase. Proc. Natl. Acad. Sci., USA 85:21-25, 1988.
  18. Fujiwara, S, Fisher, RJ, Seth, A, Bhat, NK and Papas, TS: Characterization and localization of the products of the human homologs of the v-ets oncogene. Oncogene 2:99-103, 1988.
  19. Samuel, KP, Seth, A, Zweig, M and Papas, TS: Characterization of eight human immunodeficient virus envelope polypeptides produced in E. coli. Gene 64:121-134, 1988.
  20. Wang, LC, Gao, C, Vaso, WC, Seth, A, and Chen, K: The role of v-mos in transformation, oncogenicity and metastatic potential of mink lung cells. Oncogene 3:267-273, 1988.
  21. Psallidopoulos, M, Seth, A, Dubois, G and Papas, TS: Expression of the first exon open reading frame of human myc in E. coli as a fusion protein with v-mos oncogene product. Gene Anal. Techn. 6:47-56, 1989.
  22. Seth, A, Watson, DK, Fujiwara, S, Showalter, SD and Papas, TS: Expression of human and viral ets genes in E. coli productions of human ets-2 specific monoclonal antibodies. Oncogene Res. 5:61-66, 1989.
  23. Seth, A, Watson, DK, Blair, DG and Papas, TS: C-ets-2 proto-oncogene has mitogenic and oncogenic activity. Proc. Natl. Acad. Sci, USA 86:7833-7837, 1989.
  24. Seth, A, Thompson, D, Chen, SM and Papas, TS: An improved vector for the expression of proteins in all three translational reading frames. Gene Anal. Techn. 6:97-100, 1989.
  25. Koizumi, S, Fisher, R J, Fujiwara, S, Jorcyk, C, Bhat, N, Seth, A and Papas, T S.:  Isoforms of the human ets-1 protein: Generation by alternative splicing and differential phosphorylation.  Oncogene 5:675-681, 1990
  26. Samuel, K P, Ascione, R, Kottaridis, S D, Seth, A, Lautenberger, J A, Zuber, M, Strouboulis, J and Papas, T S:  Expression of animal and human retroviral gene products in Escherichia coli with the _PL promoter pJL6 vector system.  Gene Anal. Techn. Appl. 7:178-208, 1990.
  27. Chen, ZQ, Burdett, LA, Seth, A, Lautenberger, J A and Papas, TS: Requirement of ets-2 expression for Xenopus oocyte maturation. Science 250:1416-1418, 1990.
  28. Papas, TS, Watson, D K, Sacchi, N, Fujiwara, S, Seth, A, Fisher, RJ, Bhat, NK, Mavrothalassitis, G, Koizumi, S, Jorcyk, CL, Schweinfest, CW, Kottaridis, SD and Ascione, R:  ETS family of genes in leukemia and Down syndrome.  Am. J. Med. Genet. (Suppl.) 7:251-261, 1990.
  29. Seth, A. and Papas, TS:  The c-ets-1 protooncogene has oncogenic activity and is positively autoregulated.  Oncogene 5:1761-1768, 1990.
  30. Papas, TS, Blair, DG, Watson, DK, Yuan, CC, Ruscetti, SK, Fujiwara, S, Seth, AK, Fisher, RJ, Bhat, N.K, Mavrothalassitis, G, Koizumi, S, Jorcyk, CL, Schweinfest, CW. and Ascione, R.: The ETS family of genes: Structural analysis, gene products, and involvement in neoplasia and other pathologies.  Prog. Clin. Biol. Res. 360:137-168, 1990.
  31. Seth, A, Ascione, R, Fisher, RJ, Mavrothalassitis, GJ, Bhat, NK and Papas, TS: The ets gene family.  Cell Growth Differ. 3:327-334, 1992.
  32. Watson, DK, Smyth, FE, Thompson, DM, Chen, J, Testa, JR, Papas, TS and Seth, A.: The ERGB gene: isolation and characterization of a new member of the family of human ETS transcription factors.  Cell Growth Differ. 3:705-713, 1992.
  33. Ascione, R., Thompson, DM, Thomas, R., Panayiotakis, A, Ramsay, R, Tymms, M., Kola, I and Seth, A.: Influence of nucleotides flanking the -GGAA- core sequence on ETS1 and ETS2 DNA-binding activity and the mechanism of ETS1 autoregulation. Int. J. Oncol. 1:631-637, 1992.
  34. Topol, LZ, Tatosyan, AG, Ascione, R, Thompson, DM, Blair, DG, Kola, I and Seth, A: c-ets-1 protooncogene expression alters the growth properties of immortalized rat fibroblasts.  Cancer Lett.  67(1):71-78, 1992.
  35. Panayiotakis, A, Hodge, DR, Robinson, L, Watson, DK and Seth, A: Sequence-specific binding of the ETS1 protein to the HIV-2 LTR enhancer.  J. Viral Diseases 1:53-60, 1993.
  36. Seth, A, Mariano, J, Metcalf, R, Li, H, Panayiotakis, A, Kottaridis, SD, Papaevangelou, ME and Papas, TS: Relative paucity of p53 gene mutations in male breast carcinomas.  Int. J. Oncol. 2:739-744, 1993.
  37. Seth, A, Robinson, L, Thompson, DM, Watson, DK and Papas, TS: Transactivation of GATA-1 promoter with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins: Stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody.  Oncogene 8:1783-1790, 1993.
  38. Kola, I, Brookes, S, Green, T, Garber, R, Tymms, M, Papas, TS and Seth, A: The Ets-1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes including organ formation, cell migration and tissue-modeling.  Proc. Natl. Acad. Sci. USA 90:7588-7592, 1993.
  39. Seth, A, Hodge, DR, Thompson, DM, Robinson, L, Panayiotakis, A, Watson, DK and Papas, TS: ETS family proteins activate transcription from HIV-1 long terminal repeat.  AIDS Res. Hum. Retroviruses 9:1017-1023, 1993.
  40. Seth, A, Robinson, L, Panayiotakis, A, Thompson, DM, Hodge, DR, Zhang, XK Watson, DK, Ozato, K and Papas, TS: The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins. Oncogene 9:469-477, 1994.
  41. Li, H, Hodge, DR, Pei, GK and Seth, A: Isolation and sequence analysis of the human syntaxin-encoding gene.  Gene 143:303-304, 1994.
  42. Seth, A, Palli, D, Mariano, JM, Metcalf, R, Bianchi, S, Kottaridis, SD and Papas, TS: p53 gene mutations in women with breast cancer and a previous history of benign breast disease.  Eur. J. Cancer 30A:808-812, 1994.
  43. Salesiotis, A.N, Wang, CK, Wang, CD, Burger, A, Li, H and Seth, A: Identification of novel genes from stomach cancer cell lines by differential display. Cancer Letters 91, 1995, 47-54.
  44. Thomas, RS, Tymms, M.J, Seth, A, Shannon, MF and Kola, I: ETS1 transactivates the human granulocyte-macrophage colony-stimulating factor promoter in PMA/ionomycin stimulated T cells.  Oncogene,11:2135-2143, 1995.
  45. Sumarsono, S, Tymms, M, Corrick, C, Wilson, T, Kola, R, Papas, TS, Seth, A and Kola, I: Down’s syndrome-like skeletal abnormalities in Ets2 transgenic mice.  Nature 379:534-537, 1996.
  46. Hodge, DR, Robinson, L, Watson, D, Lautenburger, J, Zhang, XK and Seth, A, Interaction of ETS and ERGB/FLI proteins with DNA is modulated by spacing between multiple binding sites as well as phosphorylation. Oncogene 12:11-18, 1996.
  47. Burger, AM, Li, H, Panayiotakis, A, Salesiotis, AN  and Seth, A. Identification of differentially expressed genes in breast cancer. International Journal of Oncology 8:395-400, 1996.
  48. Venanzoni, MC, Robinson, LR, Hodge, DR, Kola, I and Seth., A  ETS1 and ETS2 in p53 regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction. Oncogene 12:1199-1204, 1996.
  49. Bhat, N, Fischinger, P, Seth, A., Papas, TS: Pleiotropic Functions of ETS-1. Int. J. Oncology 8:841-846, 1996.
  50. Watson DK, Robinson L, Hodge DR, Kola I, Papas TS, and Seth A.: FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene 14: 213-221, 1997.
  51. Westermarck, J, Seth, A, Kahari, V-M: Differential regulation of collagenase-1 (MMP-1) gene expression by members of ETS gene family. Oncogene 14:2651-2660, 1997.
  52. Thomas, Rs, Tymms, M.J, McKinlay, LH, shannon, MF, Seth, A, Kola I: ETS1, NF B and AP1 synergistically transactivate the human GM-CSF promoter. Oncogene 14:2845-2856, 1997.
  53. Robinson, L., Papas, T. S., I. Kola, and Seth A. The ETS target genes: Isolation of novel Ets responsive genes by whole genome PCR and differential display of mRNAs expressed in Ets1 and Ets2 transformed cells. Proc. Natl. Acad. Sci. USA 94:7170-7175, 1997.
  54. Tymms MJ, Ng AYN, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I: A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene 15:2449-2462, 1997
  55. Burger, AM, Zhang, X, and Seth, A,: Detection of Novel Genes that are Up- (Di12) or Down-regulated (T1A12) with Disease Progression in Breast Cancer. European J. of Cancer Prevention 7 (suppl 1), S29-S35, 1998.
  56. Burger A, Zhang X-K, Li H, Ostrowski JL, Beatty B, Venanzoni M, Papas T, Seth A., : Down-regulation of T1A12, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas. Oncogene May 14; 16(19):2459-2467, 1998.
  57. Burger A, Li H. Zhang X-K, Pienkowska M, Venanzoni M, Vournakis J, Papas TS. and Seth A:. Breast cancer genome anatomy: Correlation of morphological changes in breast carcinomas with expression of the novel gene product Di12. Oncogene 16:327-333, 1998.
  58. Pienkowska M, Seth A.: Frequency of Squirrel monkey retroviral sequences in interferon samples. Journal of Hepatology 28:396-403, 1998.
  59. Richter, S and Seth, A:  One step direct detection of recurrent mutations in breast cancer susceptibility gene, BRCA1 by ASO PCR. International Journal of Oncology 12:1263-1267, 1998.
  60. Kulkarni GV, Lee WK, Seth A, and McCulloch CAG : The role of mitochondrial membrane potential. in Con A-induced apoptosis in fibroblasts. Experimental Cell Research 245:170-178, 1998.
  61. Zhou, J, Ng, AYN, Tymms JM, Jermiin, LS, Seth, A, Thomas RS, Kola I : A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p36.31, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene 17:2719-32 1998.
  62. McKinlay, LH, Tymms, MJ, Thomas, RS, Seth, A, Hasthorpe, S, Hertzog, PJ, Kola, I : The role of Ets-1 in Mast cell granulocyte-macrophage colony-stimulating factor expression and activation. Journal of Immunology 161:4098-105 1998.
  63. DeGeorges A, Wang F, Frierson HF Jr, Seth A, Chung, LWK, Sikes RA : Human prostate cancer expresses the low affinity insulin-like growth factor binding protein IGFBP-rP1. Cancer Research 59:2787-2790, 1999.
  64. Seth A, Giunta, S, Franceschi C, Kola I, Venanzoni MC : Regulation of the human stress response gene GADD153 expression: role of ETS1 and FLI-1 gene products. Cell Death & Differentiation 6:902-907, 1999.
  65. Beatty, BG, Qi, S, Pienkowska, M, Scherer, SW, Herbrick, J, Scheidl, T, Zhang, ZM, Kola, I and Seth, A:  Phospholipase A2 activating protein (PLA2P) an ETS2 target gene, may have a tumor suppressor role. Genomics 62(3):529-32, 1999.
  66. Seth A, Lee BK, Qi S, and Vary CPH.: Coordinate Expression of Novel Genes During Osteoblast Differentiation, Journal of Bone and Mineral Research: 15(9):1683-96, 2000.
  67. DeGeorges A, Wang F, Frierson HF Jr, Seth A, Sikes RA. Distribution of IGFBP-rP1/mac25 in normal human tissues. Journal of Histochemistry and Cytochemistry 48(6):747-54, 2000.
  68. Vary C, Li V, Raouf A, Kitching R, Kola I, Franceschi C, Venanzoni M, and Seth A: Involvement of Ets1 and Ets2 transcription factors and their targets in osteoblast function, Experimental Cell Research 257:213-222, 2000.
  69. Raouf, A, Watson DK, Kola I, and Seth, A: Ets1 protooncogene is regulated by retinoic acid: Characterization of a Functional Retinoic Acid Response Element in Ets1 Promoter. Oncogene, 19:1969-74, 2000.
  70. Kahn HJ, Yang LY, Blondal J, Lickley L, Holloway C, McCready DR, Seth A, Hanna W, Marks A: Detection of circulating cancer cells in breast cancer patients: an optimized method using CK19 mRNA. Breast Cancer Research and Treatment, 60:143-151, 2000.
  71. Raouf A. and Seth, A: Ets transcription factors and targets in osteogenesis. Oncogene, 19: 6455-63, 2000.
  72. Wang J, Lukse E, Seth A, McCulloch CA: Use of conditionally immortalized mouse cardiac fibroblasts to examine the effect of mechanical stretch on alpha-smooth muscle actin. Tissue Cell 33(1):86-96. 2000.
  73. Wang, J, Seth, A, McCulloch, CA: Force regulates muscle actin in cardiac fibroblasts. Am J Physiol Heart Circ Physiol 279 (6):H2776-85. 2000
  74. Landberg, G, Ostlund, H, Nielsen, NH, Emdin, S, Burger, AM and Seth, A, :  Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression, and increased proliferation in estrogen receptor negative tumors. Oncogene 20:3497-3505 2001.
  75. Seth, A, Catzavelos, C, Vary, C, Ascione, R:  Ets transcription factors and targets and in tumor invasion, angiogenesis and bone metastasis. Emerging Therapeutic Targets 5:87-108, 2001.
  76. Kitching, R, Qi, S, Li, V, Vary, CPH, Seth, A: Coordinate gene regulation patterns during osteoblast maturation in vitro. Journal of Bone and Mineral Metabolism 20:269-280, 2002.
  77. Hanna, WM, Kahn, HJ, Pienkowska, M, Blondal, J,  Seth, A: Marks, A. Defining a Test For HER2/neu Evaluation in Breast Cancer in the Diagnostic Setting. Modern Pathology 14:677-685, 2001.
  78. Raouf, A and Seth, A:. Discovery of osteoblast associated genes Using cDNA Microarrays. Bone  30:463-471, 2002.
  79. Raouf, A, Ganss, B, McMahon, C, Vary, C, Roughley, PJ and Seth, A: Lumican is a Major Proteoglycan Component of the Bone Matrix. Matrix Biology 21:361-367, 2002.
  80. Wang, J, Su, M, Fan, J, Seth, A, McCulloch, CA: Transcriptional Regulation of a Contractile Gene by Mechanical Forces Applied through Integins in Osteoblasts. J Biol Chem 277(25):22889-95, 2002.
  81. Venanzoni, MC, Giunta, S, Muraro, GB, Storari, L, Crescini, C, Mazzucchelli, R, Montironi, R and Seth, A: Apolipoprotein E (Apo-E) over-expression correlates with Gleason Score in undifferentiated and hormone resistant prostate cancers. International Journal of Oncology 22:779-786, 2003.
  82. Kitching, R, Li, H, Wong, MJ, Kanaganayakam, S, Beatty, B, Kahn, H and Seth, A: Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced praline rich protein. Biochemica Biophysica Acta 1625 (1):116-121, 2003.
  83. Wolvetang, EJ, Wilson, TJ, Sani, E, Busciglio, J, Hatzistavrou, T, Seth, A, Hertzog, PJ, Kola, I: ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet  12 (3):247-55, 2003.
  84. Burger, AM, Grugel, R, Landberg, G, Kitching, R and Seth, A: The Breast Cancer Associated Gene Dil2 has Oncogenic Activity. Anticancer Research 23 (3A):2027-2033, 2003.
  85. Seth, A, Kitching, R, Landberg, G, Xu, J, Zubovits, J and Burger, AM: Gene Expression Profiling of Ductal Carcinomas In Situ and Invasive Breast Tumors Anticancer Research 23 (3A):2043-2051, 2003.
  86. Subramaniam, V, Li, H, Wong, M, Kitching, R, Attisano, L. Wrana, J, Zubovits, J, Burger, A and Seth, A: The RING-H2 Protein RNF 11 is Overexpressed in Breast Cancer and is a Target of Smurf2 Ligase. British Journal of Cancer 89:1538-44, 2003.
  87. Kitching, R, Wong, MJ, Wong, DK, Burger, AM, Landberg, G, Gish, G and Seth, A: The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 Ligases. Biochimica Boiphysica Acta 1639:104-112, 2003.
  88. Millson A, Suli A, Hartung L, Kunitake S, Bennett A, Nordberg MC, Hanna W, Wittwer CT, Seth A., and Lyon E. Comparison of two quantitative polymerase chain reaction methods for detecting HER2/neu amplification. Journal of Molecular Diagnostics, 3:184-90, 2003
  89. Wang J, Chen H, Seth A, McCulloch, CA:. Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 285(5): H1871-81, Nov. 2003
  90. Li, H and Seth, A:. An RNF11:Smurf2 complex mediates ubiquitination of the AMSH protein. Oncogene 23 (10):1801-1808, 2004.
  91. Connor, M, and Seth, A: RNF11: A central role for the ring finger protein RNF11 in ubiquitin mediated proteolysis via interactions with E2s and E3s. Oncogene Reviews “Ubiquitination and Cancer”, 23 (11):2089-2095, 2004.
  92. Burger, AM and Seth, AK:.  The Ubiquitin Mediated Protein Degradation Pathway in Cancer: Therapeutic Implications. Eur J Cancer 40 (15):2217-2229, 2004.
  93. Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente XS, López-Otín C, and Seth A:. Protease Degradomics: Mass Spectrometry Discovery of Protease Substrates and the CLIP-CHIP: A Dedicated Oligonucleotide Microarray of all Human Proteases and Inhibitors. Biological Chemistry 385(6):493-504, 2004.
  94. Kahai, S, Vary, CPH, Gao, Y and Seth, A: Collagen, type V, alpha 1 (COL5A1) is Regulated by TGF-in Osteoblasts. Matrix Biol, 23(7):445-455. 2004.
  95. Li, V, Raouf, A, Kitching, R and Seth, A: Ets2 Transcription Factor Inhibits Mineralization and Affects Target Gene Expression During Osteoblast Maturation. In Vivo: International Journal of Experimental and Clinical Pathophysiology and Drug Research, 18 (5):517-24, 2004.
  96. Tanaka, H, Terada, Y, Kobayashi, T, Okado, T, Inoshita, S, Kuwahara, M, Seth, A, Sato, Y. Sasaki, S: Expression and Function of Ets-1 during experimental acute renal failure in rats. J Am Soc Nephrol 15 (12):3083-92, 2004.
  97. Landberg, G, Nilsson. K, Jirstrom, K, Ryden, L, Kitching, R, Burger, AM and Seth, A: Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression. Breast Cancer Res Treat 89(3):313-6, 2005.
  98. Wang, J, Laschinger, C, Zhao, XH, Mak, B, Seth, A, McCulloch, CA: Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. Biochem Biophys Res Commun. 330 (1):123-30, 2005.
  99. Wang J, Fan J, Laschinger C, Arora PD, Kapus A, Seth A, McCulloch CA. Smooth muscle actin determines mechanical force-induced p38 activation. J Biol Chem. 280 (8):7273-84, 2005.
  100. Gao, Y, Ganss, BW, Wang, H, Kitching, RE and Seth, A: The RING finger protein RNF 11 is expressed in bone cells during osteogenensis and is regulated by Ets1. Exp Cell Res 304 (1):127-35, 2005.