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Biography
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Prof. Gee A. Lau

Department of Pathobiology
University of Illinois at Urbana-Champaign, USA
Associate Professor

Email: geelau@illinois.edu


Qualifications

1992 Ph.D.,  Purdue University, USA
1990 M.Sc.,  University of Wisconsin-Madison, USA
1988 B.Sc.,  University of Wisconsin-Madison, USA


Publications (Selected)

  1. Rahme L, Ausubel F, Cao H, Drenkard E, Goumneov B, Lau GW, Plotnikova J, Tompkins R, Tsongalis J, Walendziewicz C. 2000. Plants and animals share functionally common bacterial virulence factors. PNAS97: 8815-8821.
  2. Lau GW, S Haataja, M Lonetto, S Kensit, A Mara, D Holden. 2001. A functional genomics of type III Streptococcus pneumoniae virulence. Mol Microbiol40: 555-571.
  3. Baldini R, Lau GW, Rahme L. 2002. The use of plant and insect hosts to model bacterial pathogenesis. Methods Enzymol 358: 3-13.
  4. Ran H, Hassett DJ, Lau GW. 2003. Human Targets of Pseudomonas aeruginosa pyocyanin. PNAS100: 14315-14320 (Track II).
  5. Potvin E, Lehoux D, Kukavica-Ibrujl I, Richard K, Sanschagrin F, Lau GW, Levesque RC. 2003. In vivo functional genomics of Pseudomonas aeruginosafor high throughput screening of novel virulence factors and antibacterial targets. Environ Microbiol 5: 1294-1308.
  6. Lau GW, Ran H, Kong FS, Hassett DJ, Mavrodi D. 2004. Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. Infect Immun 72: 4275-4278.
  7. Lau GW, Ran H, Hassett DJ, Kong FS. 2004. The role of pyocyanin in Pseudomonas aeruginosa infection. Trends Mol Med 10: 599-606.
  8. Lau GW, Britigan BE, Hassett DJ. 2005. Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils. Infect Immun73: 2550-2553.
  9. Apidianakis Y, Mindrinos M, Xiao W, Lau GW, Baldini R, Davis RW, Rahme LG. 2005. Profiling early host response to infection: Pseudomonas aeruginosapotentiates disease by restricting antimicrbial peptide gene expression. PNAS102: 2573-2578.
  10. Lau GW, Hassett DJ, Britigan BE. 2005. Modulation of lung epithelial functions by Pseudomonas aeruginosa. Trends Microbiol13: 389-397.
  11. Zhang S, Chen Y, Potvin E, Sanschagrin F, Levesque RC, McCormack FX, Lau GW. 2005.Comparative signature-tagged mutagenesis identifiesPseudomonas aeruginosa factors conferring resistance to pulmonary collectin SP-A. PLoS Pathogens1: e31.
  12. Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher     RC, Hassett DJ. 2006. Anaerobic killing of mucoid Pseudomonas aeruginosa by      acidified nitrite derivatives under cystic fibrosis airway conditions. J Clin Invest116:      436-446.
  13. Kong FS, Young LE, Ran H, Meyers M, Chen Y, Joseph P, Hassett DJ, Lau GW. 2006. Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vaculoar ATPase-dependent CFTR expression and localization. Cell Microbiol 8: 1121-1133.
  14. Borchers MT, Harris NL, Wesselkamper SC, Chen Y, Zhang S, Young L, Lau GW. 2006. The NKG2D activating receptor mediates pulmonary clearance of   Pseudomonas aeruginosa. Infect Immun74: 2578-2586.
  15. Zhang S,McCormack FX, Levesque RC, O’Toole G, Lau GW. 2007. The flagellar protein, FlgE, is a molecular target for clearance of Pseudomonas aeruginosa by SP-A. PLoS One2: e564.
  16. Platt MD, Schurr MJ, Sauer K, Vazquez G, Kukavica-Ibrulj I, Potvin E, Levesque RC, Fedynak A, Brinkman FSL, Schurr J, Hwang SH, Lau GW et al. 2008. Proteomic, microarray and signature tagged mutagenesis analysis of anaerobic Pseudomonas aeruginosa at pH 6.5, representing chronic cystic fibrosis airway     conditions. J Bacteriol190: 2739-2758.
  17. Wesselkamper SC, Eppert BL, Motz GT, Lau GW, Hassett DJ, Borchers MT. 2008. NKG2D is critical for NK cell activation in host defense againstPseudomonas aeruginosa respiratory infection. J Immunol 181: 5481-5489.
  18. Caldwell CC, Chen Y, Goetzmann H, Hao H, Borchers MT, Hassett DJ, Young LR, Mavrodi D, Thomashow L, Lau GW. 2009. Pseudomonas aeruginosapyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol175: 2473-88.
  19. Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton M, Hoiby N. 2010.Pseudomonas aeruginosaBiofilm Infections in Cystic Fibrosis: Insights Into Pathogenic Processes and Treatment Strategies. Expert Opinion On Therapeutic Targets14: 117-130.
  20. Kuang ZZ, YH Hao, SH Hwang, S Zhang, E Kim, HT Akinbi, MJ Schurr, RT Irvin, DJ Hassett and Lau GW. 2011. The flagella of Pseudomonas aerugniosamediate resistance to SP-A-mediated membrane permeabilization by multiple mechanisms.Mol Microbiol79:1220-1235.
  21. Zhu L, Lau GW. 2011.Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by A Modified Competence Stimulating Peptide. PLoS Pathogens7:e1002241.
  22. Kuang ZZ, Hao YH, Walling BE, Jeffries JL, Lau GW. 2011. Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degradation of pulmonary surfactant protein A. PLoS One: e27091.
  23. Hao Y, Kuang Z, Walling BE, Bhatia S, Sivaguru M, Chen Y, Gaskins HR, Lau GW. 2012.Pseudomonas aeruginosapyocyanin causes airway goblet cell hyperplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2.Cell Microbiol14:401-15.


Profile Details

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