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Biography
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Dr. Praveen P Nekkar Rao

School of Pharmacy, Health Sciences Campus

University of Waterloo, Canada

Medicinal Chemist and Assistant Professor


Email: praopera@uwaterloo.ca


Qualifications

2004 Ph.D., Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada

1998 M.Sc., College of Pharmacy, Mangalore University, India

1995 B.Sc., College of Pharmacy, Mangalore University


Publications (selected)

  1. Tarek Mohamed, Jacky C K Yeung, Maryam S Vasefi, Michael A Beazely, Praveen P N Rao. Development and evaluation of multifunctional agents for potential treatment of Alzheimer's Disease: Application to a pyrimidine-2,4-diamine template.Bioorg.Med.Chem.Lett.22: 4707-4712,2012.
  2. Keriman Özadalı, Fügen Özkanlı, Sarthak Jain, Praveen P N Rao, Carlos A. Velázquez-MartínezSynthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.Bioorg.Med.Chem.20: 2912-2922,2012.
  3. Tarek Mohamed, Praveen P N Rao Alzheimer’s disease: Emerging trends in small molecule therapies. Curr. Med. Chem.18: 4299-4320,2011.
  4. Praveen P N Rao, Tarek Mohamed. Current and emerging at-site pain medications: A review.J. Pain Re.4: 279-286,2011.
  5. Rahim, M. R., Praveen P N Rao., Bhardwaj, A., Kaur, J., Huang, Z., Knaus, E. E. Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorg.Med.Chem.Lett.21: 6074-6080,2011.
  6. Tarek Mohamed, Jacky C K Yeung, Praveen P N Rao Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Ab-aggregation inhibitors: synthesis and biological evaluation.Bioorg.Med.Chem.Lett.21:5881-5887,2011.
  7. Tarek Mohamed, Praveen P N Rao. Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorg.Med.Chem.19: 2269-2281,2011.
  8. Tarek Mohamed, Praveen P N Rao. Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorg.Med.Chem. Lett.20: 3606-3609,2010.
  9. Praveen P N Rao, Saad, N. Kabir, Tarek Mohamed. Nonsteroidal anti-inflammatory drugs (NSAIDs): Progress in small molecule drug development.Pharmaceuticals3:1530-1549, 2010.
  10. Gang Yu,Praveen P N RaoMorshed A Chowdhury, Khaled R A Abdellatif, Ying Dong, Dipankar Das, Carlos A Velázquez, Mavanur R Suresh, Edward E Knaus. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.Bioorg.Med.Chem. Lett.20:2168-2173, 2010.
  11. Gang Yu, Morshed A Chowdhury, Khaled R A Abdellatif, Ying Dong,Praveen P N Rao, Dipankar Das, Carlos A Velázquez, Mavanur R Suresh, Edward E Knaus. Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorg. Med. Chem. Lett.20:896-902, 2010.
  12. Praveen P N Rao, Rajesh K. Grover. Apricoxib, a COX-2 inhibitor for the potential treatment of pain and cancer. IDrugs 12:711-722, 2009.
  13. Praveen P N Rao, Edward, E Knaus.Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): COX inhibition and beyond. J. Pharm. Pharmaceut. Sci. 11:81s-110s, 2008.
  14. Velázquez C A, P N Praveen, Rao, Citro, M L, Keefer, L K, Edward E Knaus. O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. Bioorg. Med. Chem. 15:4767-4774, 2007.
  15. Zarghi, A, P N Praveen, Rao, Edward, E Knaus.Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity. Bioorg. Med. Chem. 15:1056-1061, 2007.
  16. Zarghi, A, P N Praveen, Rao, Edward, E Knaus.Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: Replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere. J. Pharm. Pharmaceut. Sci. 10:159-167, 2007.
  17. Qiao-Hong, Chen, P N Praveen, Rao, Edward, E Knaus. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs). Bioorg. Med. Chem. 14:7898-7909, 2006.
  18. P N Praveen, Rao, Qiao-Hong, Chen, Edward, E Knaus. Synthesis and structure-activity relationship studies of 1,3-diphenylprop-2-yn-1-ones: Dual inhibitors of cyclooxygenases and lipoxygenases. J. Med. Chem. 49:1668-1683, 2006.
  19. P N Praveen, Rao,Md. Jashim, Uddin, Edward, E Knaus.Design, synthesis and structure-activity relationship (SAR) studies of substituted-3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. J. Med. Chem. 47: 3972-3990, 2004.
  20. P N Praveen, Rao, Mohsen, Amini, Huiying, Li, Amgad, G Habeeb, Edward, E Knaus. Design, synthesis and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. J. Med. Chem. 46:4872-4882 2003.
  21. P N Praveen, Rao, Mohsen, Amini, Huiying, Li, Amgad, G Habeeb, Edward, E Knaus. 6-alkyl, alkoxy or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 13:2205-2209, 2003.
  22. P N Praveen, Rao, Amgad, G Habeeb, Edward, E Knaus. Design and syntheses of Novel 1,1-dihalo-2,3-diphenylcyclopropanes as potential cyclooxygenase-2 (COX-2)  inhibitors with analgesic-antiinflammatory activity. Drug Dev. Res. 55:79-90, 2002.
  23. P N Praveen Rao,Mahadev, Rao. M. N. A. Rao .Gastroprotective effect of 1-phenyl-3 (4-hydroxy-3,5-di-tert.butylphenyl)-prop-en-1-one in rats. J. Pharm. Pharmacol. 50: 1371-1375, 1998.


Profile Details

http://science.uwaterloo.ca/~nekkar/