Prof. Yung-Fu Chang

Prof. Yung-Fu Chang

Department of Population Medicine and Diagnostic Sciences

Cornell University, USA



1984 Ph.D., Texas A&M University, Microbiology

1981 M.Sc., University of Idaho, Immunology/Pathology

1974 DVM, Pintung Institute of Agriculture, Veterinary Medicine

Publications (Selected)

  1. Janvilisri T., J. Scaria, R. Gleed, S. Fubini, M. M. Bonkosky, Y. T. Grohn, and Y. F. Chang. 2010. Development of a microarray for identification of pathogenic Clostridium species. Diagn. Microbiol. Infect. Dis. 66: 140-147.
  2. Yan, W., S. M. Faisal, S. P. McDonough, C. F. Chang, M. J. Pan, and Y. F. Chang. 2010. Identification and characterization of OmpA-like proteins as novel vaccine candidates for Leptospirosis. Vaccine. 28: 2277-2283.
  3. Janvilisri T., J. Scaria, and Y. F. Chang. 2010. Transcriptional profiling of Clostridium difficile and Caco-2 cells during infection. J. Infect. Dis. 202: 282-290.
  4. Yan, W., S. M. Faisal, T. Divers, S. P. McDonough, B. Akey, and Y. F. Chang. 2010. Experimental L. interrogans serovar Kennewicki infection of horses. J. Vet. Intern. Med. 24: 912-917.
  5. Lin Y. P., S. P. McDonough, Y. Sharma and Y. F. Chang. 2010. The terminal immunoglobulin-like repeats of LigA and LigB of Leptospira enhance their binding to gelatin binding domain of fibronectin and host cells. Plos one: 5: e11301.
  6. Davis, M. A., J. Y. Lim, Y. Soyer, H. Harbottle,Y. F. Chang, D. New, L. H.Orfe, T. E. Besser, and D. R. Call Development and validation of a resistance and virulence gene microarray targeting Escherichia coli and Salmonella enterica. J Microbiol Methods. 2010 82: 36-41.
  7. Scaria, J., L. D Warnick, J. B. Kaneene, K. May, C. H. Teng and Y. F. Chang. 2010. Comparison of phenotypic and genotypic antimicrobial profiles in Eschericia coli and Salmonella enterica from the same dairy cattle farms. Mole. Cell. Probes. 24: 325-45.
  8. Scaria, J., L. Ponnala, T. Janvilisri, W. Yan, L. A. Mueller and Y. F. Chang. 2010. Analysis of Ultra Low Genome Conservation in Clostridium difficile. PLoS One. 5: e15147.
  9. Rama, R., V. Rajanikanth, R. U. M. Palaniappan, Y. P. Lin, H. He, S. P. McDonough, Y. Sharma and Y. F. Chang. 2010. Big Domains are Novel Ca2+-binding Modules: Evidences from Big Domains of Leptospira immunoglobulin-like (Lig) Proteins. PLoS One. e14377.
  10. Rajkhowa, S., J. Scaria, D. L Garcia, K. A. Musser, B. L. Akey, and Y. F. Chang. 2010. Analysis of Escherichia coli O157 clinical isolates by multilocus sequence typing. BMC Research Notes. 3: 343.
  11. Lin, Y. P., C. J. Kuo, X. Koleci, S. P. McDonough, and Y. F. Chang. 2011. Manganese binds to Clostrdium difficile Fbp68 and is essential for fibronectin binding. J. Biol. Chem. 286: 3957-3969, 2011.
  12. Lin, Y. P., S. P. McDonough, Y. Sharma, and Y. F. Chang. 2011. Leptospiral immunoglobulin-like protein (LigB) binds to the C-teminal fibrinogen αC domain inhibiting fibrin clot formation, platelet adhesion, and aggregation. Mol. Microbiol. 79: 1063-1076.
  13. Faisal S. M, J. W. Chen, S. P. McDonough, C. F. Chang, C. H. Teng, and Y. F. Chang. 2011. Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses. Vaccine 29: 2381-2391.
  14. Scaria J., T. Janvilisri, S. Fubini, R. D. Gleed, S. P. McDonough, and Y. F. Chang. 2011. Clostridium difficile transcriptome analysis using pig ligated loop model reveals modulation of pathways not modulated in vitro. J. Infect. Dis. 203: 1613-1620.
  15. Rama, R., Y. Sharma and Y. F. Chang. 2011. Ca2+-binding and spectral properties of the common region of surface exposed Lig proteins of Leptospira. Comm. & Integra. Biol. 4(3): 1-3.
  16. Cao Y, S. M. Faisal, W. Yan, Y. C. Chang, S. P. McDonough, N. Zhang, B. L. Akey, and Y. F. Chang. 2011. Evaluation of novel fusion proteins derived from extracellular matrix binding domains of LigB as vaccine candidates against leptospirosis in a hamster model. Vaccine. 29: 7379-86
  17. Mark-Carew M. P, S. E. Wade, Y. F. Chang, S. Schaaf, and H. O. Mohammed. 2012. Prevalence of Giardia duodenalis assemblages among dairy herds in the New York City Watershed. Vet Parasitol. 185: 151-157
  18. Szonyi B, Y. F. Chang, S. E. Wade, and H. O. Mohammed. 2012. Evaluation of factors associated with the risk of infection with Cryptosporidium parvum in dairy calves. Am. J. Vet. Res. 73: 76-85.
  19. Chen J. W, S. M. Faisal, S. Chandra, S. P. McDonough, M. A. Moreira, J. Scaria, C. F. Chang, J. P. Bannantine, B. Akey B, and Y. F. Chang. 2012 Immunogenicity and protective efficacy of the Mycobacterium avium subsp. paratuberculosis attenuated mutants against challenge in a mouse model. Vaccine. 30: 3015-3025.
  20. Kuo C. J, H. Bell, C. L. Hsieh, C. P. Ptak, and Y. F. Chang. 2012. The novel Mycobacteria antigen 85 complex binding motif on Fibronectin. J Biol Chem. 287: 1892-1902.
  21. Mao BH, Chang YF, Scaria J, Chang CC, Chou LW, Tien N, Wu JJ, Tseng CC, Wang MC, Chang CC, Hsu YM, Teng CH. 2012. Identification of Escherichia coli genes associated with urinary tract infections. J. Clin. Microbiol. 50: 449-456.
  22. Priest, H; I, Nita; D. Schlafer, T. Divers, B. Wagner, A. Glaser, Y. F. Chang, T. Stokol, 2012. Diagnosis of Borrelia-Associated Uveitis in Two Horses. Vet. Ophthal. Epublication ahead.
  23. Chen, J. W., J. Scaria and Yung-Fu Chang. 2012. Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress. PLOS one. 7: e37884.