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Biography
David X. Liu

David X. Liu, Ph.D.

4452 S. Elm, Broken Arrow, OK 74014

Phone: 918-446-6413 (Office); Cell: 509-655-4368; Email: liud@nsuok.edu

Education

  1982                 B.S. in Biochemistry

          Fudan University, Shanghai, China

          Thesis: Isolation and characterization of plasmids harbored in thermophilic bacteria.

             Advisor: Prof. Shen Ren-quan

 1985                   M.S. in Molecular Biology

          Shanghai Institute of Biochemistry, Chinese Academy of Sciences

          Thesis: Transcription regulation of 5S ribosomal RNA gene in eukaryotes

          Advisor: Prof. Li Zai-ping

  1996                 Ph.D. in Molecular Genetics

          City University of New York, New York, NY.

          Thesis: Growth-dependent regulation of ribosomal RNA transcription in Bacillus subtilis

          Advisor: Prof. Rivka Rudner

Positions and Employment History

  1986-1987         Research Assistant

The 7th Laboratory (Gene Regulation), Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China

  1988-1989         Lecturer

                            Department of Biology, Qingdao University, Qingdao, Shandong, China

  1989-1991      Visiting Research Specialist                                     

                        Department of Biological Sciences, University of Illinois at Chicago, IL.

  1997-1998      Postdoctoral fellow

                        New York University Medical Center, New York, NY.

                        Project: Cell cycle deregulation in cancer cells.  Advisor: Dr. Michele Pagano.

  1998-2002       Postdoctoral fellow

                        Columbia University College of Physicians and Surgeons, New York, NY.

                        Project: Mechanism of neuronal apoptosis.  Advisor: Dr. Lloyd Greene.

  2002-2006      Associate Research Scientist                             

                        Department of Pathology

                        Columbia University College of Physicians and Surgeons, New York, NY.

  2006-2013      Assistant Professor (tenure-track), Principle Investigator                         

                        Department of Neural and Behavioral Sciences

                        Pennsylvania State University College of Medicine, Hershey, PA

  2013-2019      Associate Professor (tenure-track), Principle Investigator                      

                        Department of Pharmaceutical Sciences

                        Washington State University College of Pharmacy, Spokane, WA

  2019-present Associate Professor (tenure-track), Principle Investigator                      

                        Department of Natural Sciences

                        Northeastern State University Gregg Wadley College of Science & Health Professions

Honors and Awards

  2017-2018       National EMPEROR Science Award Mentor

  2015                  F1000Prime Recommendation of our paper Madarampalli et al., Cell 162(3):580-592. https://f1000.com/prime/725675029

  2011             Breast Cancer Research Era of Hope Scholar, U.S. Department of Defense

  2008             Beckman Young Investigator Nominee, Penn State University

  1998-2001       Research Fellow, Blanchette Rockefeller Foundation.

NIH Study Sections and Other Grant Review and Committee Panels

  2016/11             Member, NIH Special Emphasis Panel (SEP) for Oncology 1-Basic Translational IRG R15 AREA grant ZRG1 OBT-J (80)

  2017/04           Member, The Research Foundation of the City University of New York (RFCUNY) Peer Review Program on an NIH SCORE study

  2017/05           Member, NIH Special Emphasis Panel (SEP) for Neural Regulation of Cancer R01/R21 grant ZRG1 OBT-J (55) R

  2017/05             Member, NIH Special Emphasis Panel (SEP) for Neural Regulation of Cancer R01/R21 grant ZRG1 OBT-H (07) S

  2017/09           Member of Program Committee, 5th Annual International Conference on Pharmacology and Pharmaceutical Sciences (PHARMA 2017; http://pharma-conf.org/Committee.html).

Editorial Boards and Professional Society

  2002-2010      Member, Society for Neuroscience                                              

  2008-present   Member, American Association for Cancer Research                   

  2011-present   Member, American Society for Biochemistry and Molecular Biology     

  2012-present   Advances in Biological Chemistry (Editorial Board)

  2012-present   Cell and Developmental Biology    (Editorial Board)                     

  2013-present American Journal of Cancer Biology (Senior Editor)

  2014-present American Journal of Pharmacology and Toxicology (Regional Editor)

  2014-present   International Journal of Cancer and Oncology (Editorial Board)

  2014-present   Journal of Cytology & Molecular Biology  (Editorial Board)

  2014-present   Journal of Pharmaceutical Science & Drug Designing

  2015-present   Journal of Neurooncology

  2016-present   Neuro-Oncology: Open Access

Ad Hoc Journal Reviewers

Biochem Biophys Res. Comm.; Biochimica et Biophysica Acta; BMC Cancer; Brain Res. Bulletin;

Cancer Biology & Therapy; Cancer Research; Cell and Developmental Biology;

Current Pharmaceutical Design; J. Biochemistry; J. Biological Chemistry; J. Neurochemistry;

J. Neuroscience; J. Qingdao Univ; Life Sciences; Molecular and Cellular Biology;

Molecular Cancer Research; Oncogene;

PNAS (Proceedings of the National Academy of Sciences USA)

Institutional Committees

  2016-2018       PharmD Honors Program Committee, WSU College of Pharmacy

  2016               Faculty Awards Workgroup, WSU College of Pharmacy

  2015-2018       Student Progress Committee, WSU College of Pharmacy

  2014-2015       Ph.D. Admissions Committee, WSU College of Pharmacy

  2012             Biomedical Sciences Graduate Core Curriculum Task Force, PSU COM

  2010-2013       Molecular Medicine Graduate Recruitment Committee, PSU College of Medicine

  2010-2013       Biomedical Sciences Graduate Program Advertising Committee, PSU COM

  2008-2013       Committee for Biomedical Sciences and Engineering Seminar Series, PSU COM

  2008             Department of Neural and Behavioral Sciences Faculty Recruitment Committee, PSU COM

  2007-2010      Cell and Molecular Biology Graduate Advisory Committee, PSU COM

  2007-2010       Cell and Molecular Biology Graduate Recruitment Committee, PSU COM

  2006-2013       Graduate Faculty of the following PSU Graduate Programs

                        Anatomy Program, Cell and Developmental Biology Program, Cell and Molecular Biology Program, Biomedical Sciences Program, Genetics Program, M.D/Ph.D Program, Molecular Medicine Program and Neuroscience Program

Teaching (underlined are those served as Course Director/Co-Director)

  2020(expected)  Biol 4412 Research in Biology, NSU College of Pharmacy Science & Health Professions

  2020(expected)  Biol 4002 Experimental Design, NSU College of Pharmacy Science & Health Professions

  2019-2020      Biol 3124 Cell Biology, NSU College of Pharmacy Science & Health Professions

  2019-2020      Biol 4232 Molecular & Cellular Bio Lab, NSU College of Pharmacy Science & Health Professions

  2019             Biol 4242 Trends & Issues in Molec. Bio, NSU College of Pharmacy Science & Health Professions

  2019-present   Biol 4411 Research in Biology, NSU College of Pharmacy Science & Health Professions

  2018             PharmSci 576 Biophysical Methods, WSU College of Pharmacy

  2017             PharmSci 576 Biophysical Methods, WSU College of Pharmacy

  2016             PharmSci 572 Current Topics (Fundamentals) of Cancer Biology, WSU College of Pharmacy

  2016             PharmSci 576 Biophysical Methods, WSU College of Pharmacy

  2014-2019       PharmSci 597 Graduate Seminar, WSU College of Pharmacy

  2014             PharmSci542 Integrated Pharmacology IV, WSU College of Pharmacy

  2008-2013       Biomedical Sciences 597A, PSU College of Medicine

  2011-2013       Neuro 520, PSU College of Medicine

  2009             Cell and Developmental Biology IBIOS 592, PSU University Park

  2008-2013       Cell and Molecular Biology 597, PSU College of Medicine

  2008-2009       Genetics 590, PSU College of Medicine

  2008             Genetics 597, PSU College of Medicine

  2009-2010       Cell and Molecular Biology 506, PSU College of Medicine

  2007             Cell and Molecular Biology 591, PSU College of Medicine

  1992-1996       Principle Biology, City Univ. of NY

  1993-1995       Molecular Genetics, City Univ. of NY

  1988-1988       Cell and Molecular Biology, Qingdao University

  1988-1989       Biochemistry, Qingdao University

Current and Former Trainees (underlined co-authored at least one peer-reviewed manuscript with me) 

  Postdoctoral Scholars and Research Faculty/Visiting Professor:

  2006-2009   Guangfu Li (Current position: Assistant Professor, University of Virginia)

Co-authored: Cell 162(3):580-592, 2015; J. Biol. Chem. 286(23):20251-9, 2011, J. Biol. Chem. 286(9):7705-13, 2011; and Molecular Cancer Research 7(6):933-43, 2009.

  2012-2014         Yunsheng Yuan (Current position: Assistant Professor, Department of Agricultural Sciences, Shanghai Jiaotong University, Shanghai, China)

                  Co-authored: Cell 162(3):580-592, 2015 and J. Biol. Chem. 293(8):2939-2948, 2018.

  2014-2016   Eugene Kim (Current position: Adjunct Assistant Professor, Department of Medical Sciences, WSU)

Co-authored: Cell Cycle 14(20):3215-6, 2015.

  2014-2015      Guihai Zhang (Current position: Director and Associate Professor, Zunyi Medical College, Guizhou, China)

  2015-2016      Xiuping Zhang (Current position: Associate Professor, College of Animal Science, Tarim University, Alar, Xinjiang, China)

  2011-2012     Suresh Anaganti (Current position: Senior Scientist, Keystone Biotech, Inc, PA)

  2012-2013         Min He (Current position: Professor and Deputy Director, Cancer Research Institute, University of Guangxi, China)

  2014-2015   Bhanupriya Madarampalli (Current position: Postdoctoral scholar, Univ. of Washington, Seattle, WA)

                  Co-authored: Cell 162(3):580-592, 2015.

  Graduate Students, Rotation Students, Undergraduate Students and Interns:  

  2020(expected)      Lindsey Howe, undergraduate student at NSU

  2020(expected)   Tyler Gore, undergraduate student at NSU

  2020(expected)   Ashley Kennedy, undergraduate student at NSU

  2019-present        Leon Elias, undergraduate student at NSU

  2019-present        Ciboney Ware, undergraduate student at NSU

  2017-2019   Phillip Yan (B.Sc. 2016, Cornell University graduate)

  2017-2019   Jordan Nicols (B.Sc. 2017, University of Washington graduate)

  2016-2018   Victoria Chong (PharmD Honors Program student, Washington State University)

  2016-2017   Henning Knipprath (Whitworth University student intern)

                  Co-authored: J. Biol. Chem. 293(8):2939-2948, 2018.

  2016             Luke Verst (Whitworth University student intern)

  2016             Sarkar, Soumyadeep (Ph.D. candidate, Washington State University)

  2015-2018   Edward Liu (Mead High School summer student intern)

  2015-2017   Roberto Murillo (Whitworth University student intern)

  2015-2016   Thaok Nguyen (PharmD Honors Program student, Washington State University)

  2015-2016   Zahrah Ali (PharmD Honors Program student, Washington State University)

  2015             Yadira Paramo (Ph.D. candidate, Washington State University)

  2015             Alex Stoudt (Undergraduate student, Washington State University-Pullman)

  2014-2019   Karri Gaither (Ph.D. candidate, Department of Pharm Sci., WSU)

                  Co-authored: J. Biol. Chem. 293(8):2939-2948, 2018.

  2014             Josiah Hopkins (Mead High School graduate, pre-undergraduate to University of Washington)

  2014-2015   Dunxin Shen (Ph.D. candidate, Washington State University)

  2012-2014     Kathleen Lengel (Current position: Ph.D. candidate, Penn State University).

Co-authored: Cell 162(3):580-592, 2015; Cell Cycle 14(20):3215-6, 2015 and Cell and Development Biol. 1:e114. doi:10.4172/2168-9296.1000e114, 2012.

  2011              Sadie Hogan (Current position: Ph.D. candidate, Penn State University)

  2011              Jeffery Nguyen (Current position: M.D./Ph.D. candidate, Penn State University)

  2010              Dongyin Guan, M.S. (Current position: Ph.D. candidate, Case Western Reserve University)

Co-authored: J. Biol. Chem. 286(23):20251-9, 2011.

  2010-2011     Ming Gao, M.S.

  2010-2011     Zhengshan Liu, M.S.

                  Co-authored: J. Biol. Chem. 286(23):20251-9, 2011.

  2010-2012     Dan Liu, M.S. (Current position: Research Assistant, University of Maryland)

Co-authored: JBC 286(23):20251-9, 2011; JBC 287(23):19599-609, 2012; Cell 162(3):580-592, 2015.

  2010              Matthew Moureau (Current position: Ph.D. candidate, Penn State University)

Co-authored: J. Biol. Chem. 286(9):7705-13, 2011.

  2009-2011     Xijun Liu, M.S. (Current position: Ph.D. candidate, University of Zhejiang Sci-Tech, China)

                  Co-authored: J. Biol. Chem. 287(23):19599-609, 2012; BMC Cancer 10:684-694, 2010.

  2009              Jeremy Haakenson (Current position: Ph.D. candidate, Penn State University)

Co-authored: Targeting New Pathways and Cell Death in Breast Cancer.  Ed. Rebecca L. Aft. InTech, ISBN 978-953-51-0145-1, pp. 71-83.

  2008              Douglas Dluzen (Current position: Ph.D. candidate, Penn State University)

Co-authored: J. Biol. Chem. 286(9):7705-13, 2011.

  2008              Diana Tacelosky (Current position: M.D/Ph.D. candidate, Penn State University)

Co-authored: J. Biol. Chem. 286(9):7705-13, 2011.

  2007              Abbas Alibhoy (Current position: Ph.D. candidate, Penn State University)

  Technician:  

  2010-present        Michelle (Yidi) Xu, M.S.

Co-authored: JBC 286(23):20251-9, 2011; Cell 162(3):580-592, 2015 and JBC 293(8):2939-2948, 2018.

Graduate Student Thesis Committees:

  2017-2019   Mahamudul Haque  (Ph.D. candidate, Department of Pharm Sci., WSU)

  2015-2019   Solomon Agere (Ph.D. candidate, Department of Pharm Sci., WSU)

  2015-2019   Ana Vergara (Ph.D. candidate, Department of Pharm Sci., WSU)

  2015-2019   Aimee Bell (Ph.D. candidate, Department of Pharm Sci., WSU)

  2014-2019   Karri Gaither (Ph.D. candidate, Washington State University)

  2014-2015     Mandi Hopkins (Ph.D candidate, Department of Pharm Sci., WSU)

  2013-2015     Dustin Rae (Ph.D candidate, Department of Pharm Sci., WSU)

  2010-2013     Kari Duck (PhD candidate, CDB Program, PSU,).

  2007-2010     Jenn Wentzel (Anatomy MS Program, PSU).

  2006-2007     Soniya Sinha (Genetics MS Program, PSU).

Research Funding

Current:

                          R15CA205375 (PI: Liu, DX)           01/01/17-12/31/19 (extended due to institution change)

                          NIH NCI                                    $456,000

Mechanism of ATF5 addition in breast cancer (active)

Pending:

                          RO1 (PI: Liu, DX)                           07/01/19-06/30/24

                          NIH NCI                                    $1,912,500

Role of ATF5 in breast cancer

                         

Recommended for Funding as an Alternate:

                          CA093484 (PI: Liu, DX)                   07/01/10-06/31/13            

U.S. Department of Defense           $1,576,415

Regulation of WNT/beta-Catenin Signaling by ATF5 in Melanoma

Completed:     

Start-Up Founding Grant (PI: Liu, DX)   07/01/13-06/30/16                     

Washington State U. College of Pharmacy   $550,000

Role of ATF5 in breast cancer

                          RSG-08-288-01-GMC (PI: Liu, DX)                09/01/08-12/31/13            

American Cancer Society                      $720,000

Mechanism of ATF5 pro-survival function in cancer cells

                          BC085617 (PI: Liu, DX)                   08/01/09-07/31/14          

U.S. Department of Defense            $116,324

Identification of ATF5-interacting SH3-containing proteins in breast cancer cells

Dean’s Feasibility Grant (PI: Liu, DX)    07/01/08-06/30/09                     

Penn State College of Medicine              $25,000

Identification of regulated neuronal death-genes

Start-Up Founding Grant (PI: Liu, DX)   07/01/06-06/30/09                     

Penn State College of Medicine              $300,000

Function of ATF5 in glioma

Peer-Reviewed Publications

2018

1.         Xia P, Liu Y, Chen J, Coates S, Liu DX, Cheng Z. (2018). Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy.  J. Biol. Chem. 293(51):19672-19685.

2.         Yuan Y, Gaither K, Kim E, Liu E, Hu M, Lengel K, Qian D, Xu Y, Wang B, Knipprath H, Liu DX*. (2018). SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome.  J. Biol. Chem. 293(8):2939-2948.

2017

3.         Wang M, Hu M, Li Z, Qian D, Wang B, Liu DX*. (2017). miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma. Biochem Biophys Res Commun. 490(4):1260-1267.

4.         Hu M, Wang B Qian D, Huang R, Wang M, Li L, Zhang L, and Liu DX*. (2017) Human cytomegalovirus immediate-early protein promotes survival of glioma cells through interacting and acetylating ATF5.  Oncotarget  8:32157-32170.

5.         Qian X, Li X, Cai Q, Zhang C, Jiang Y, Lee J, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang B, Liu DX, Jiang T, Lu Z (2017). Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy.  Molecular Cell 65(5):917-931.

2016

6.         Cheng Y, Ren X, Yuan Y, Shan Y, Zhang L, Takahashi Y, Yang JW, Li Y, Li L, Chen X, Liu DX, Ryazanov A, and Yang LM (2016).  eEF-2 Kinase is a Critical Regulator of Warburg Effect through Controlling Translational Elongation of PP2A-A.  Oncogene 35(49):6293-6308.

2015

7.         Lengel K, Kim E, and Liu DX* (2015).  ATF5 regulates the cell cycle-dependent centrosome cycle.  Cell Cycle 293(8):2939-2948.

8.         Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li, G., Yang J, Liu X, Lu Z and Liu DX* (2015).  ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.  Cell 162(3):580-592.

F1000Prime Recommended Aug. 15, 2018. https://f1000.com/prime/725675029

2014

9.         Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, and Lu Z (2014). PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.  Nature Communications 5, 5566.  doi:10.1038/ ncomms6566. 

2013

10.     Cheng Y, Ren X, Gowda ASP, Shan Y, Zhang L, Yuan Y-S, Patel R, Wu H, Huber-Keener K, Yang JW, Liu DX, Spratt TE and Yang J-M (2013).  Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.  Cell Death and Disease 4, e731. doi:10.1038/cddis.2013.254

2012

11.     Hu M, Wang B*, Qian D, Li L, Zhang L, Song X, and Liu DX* (2012).  Interference with ATF5 function enhances the sensitivity of human pancreatic cancer cells to paclitaxel-induced apoptosis.  Anticancer Res. 32(10):4385-94.

12.     Lengel KL and Liu DX* (2012).  Cell type-dependent function of ATF5:  Where we go from here.  Cell and Development Biol. 1:e114. doi:10.4172/2168-9296.1000e114.

13.     Zhang Y, Cheng Y, Ren X, Horis T, Huber-Keener KJ, Zhang L, Yap KL, Liu DX, Shantz L, Qin Z, Zhang S, Wang J, Wang HG, Shih IM, and Yang JM (2012).  Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis.  Cancer Res. 72(16):4262-75.  PMID: 22665267.

14.     Chen A, Qian D, Wang B, Hu M, Lu J, Qi Y, and Liu DX (2012).  ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells.  Intl. J. Gynecological Path. 31(6):532-7.  PMID: 23018213. 

15.     Liu X, Liu D, Qian D, Dai J, Jiang S, Stanley B, An Y, Yang J, Wang B, Liu X and Liu DX* (2012). Nucleophosmin (NPM1/B23) interacts with ATF5 and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.  J. Biol. Chem. 287(23):19599-609.  PMID: 22528486.

2011

16.     Liu DX*, Qian D, Wang B, Yang JM, and Lu Z (2011). p300-dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol. Cell. Biol., 31(18):3906-3916.  PMID: 21791614.

17.     Dluzen D, Li G, Tacelosky D, Moreau M, and Liu DX* (2011). Bcl-2 is a downstream target of ATF5 that mediates the pro-survival function in a cell type-dependent manner. J. Biol. Chem. 286(9):7705-13.  PMID: 21212266.

18.     Zhang Y, Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu DX, Qin ZH, Shih IM and Yang JM (2011).  NAC1 modulates sensitivity of ovarian cancer cells to cisplatin via altering the HMGB1-mediated autophagic response. Oncogene 31(8):1055-64.  PMID: 21743489.

19.     Li G, Xu Y, Guan D, Liu, Z and Liu DX* (2011). HSP70 promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J. Biol. Chem. 286(23):20251-9. PMID: 21521685.

20.     Zheng Y, Yang W, Xia Y, Hawke D, Liu DX and Lu, Z (2011). Ras-induced and ERK1/2 phosphorylation-dependent isomerization of PTP-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.  Mol. Cell. Biol., 31(21):4258-4269.  PMID: 21876001.

2010

21.     Liu X, Yang JM, Zhang SS, Liu XY, and Liu DX* (2010). Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide.  BMC Cancer 10:684-694.

22.     Samarrai W, Liu DX, White AM, Studamire B, Edelstein J, Srivastava A, Widom RL, and Rudner R (2010). Differential response of Bacillus subtilis ribosomal 1 RNA promoters to nutritional stress.  J. Bact. 193(3): 723-33.

23.     Hu M, Qian D, Hou Y, Peng K, Li L, Song X, Liu DX, and Wang B (2010). Expression of ATF5 and Bax in the apoptosis of pancreatic cancer cells SW1990 induced by paclitaxel.  J. Med. Postgrad. (China), 23(11):1127-31.

2009 and before

24.     Wu H, Zhu H, Liu DX, Niu TG, Ren X, Patel R, Hait, WN, and Yang JM (2009).  Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy.  Cancer Research 69(6):2453-60.

25.     Li G, Li W, Angelastro JM, Greene LA, and Liu DX* (2009).  Identification of a novel DNA binding site and a transcription target for ATF5 in C6 glioma and MCF-7 breast cancer cells.  Molecular Cancer Research 7(6):933-43. 

26.     Greene LA, Liu DX, Troy CM, and Biswas SC (2007). Cell Cycle Molecules Define A Pathway Required For Neuron Death In Development And Disease.  Biochimica et Biophysica Acta 1772:392-401.

27.     Biswas SC, Liu DX, and Greene LA (2005).  Bim is a direct target of a neuronal E2F-dependent apoptotic Pathway.  J. Neurosci., 25(37):8349-58.

28.     Liu DX*, Nath N, Chellappan SP, and Greene LA (2005).  Regulation of neuronal survival and death by p130 and associated chromatin modifiers.  Genes&Dev. 19(6):719-32.

29.     Greene LA, Biswas SC, and Liu DX (2004).  Cell cycle molecules and vertebrate neuron death: E2F at the hub.  Cell Death Differ. 11(1):49-60.

30.     Liu DX*, Biswas SC, and Greene LA (2004).  B-myb and C-myb play required roles in neuronal apoptosis evoked by NGF deprivation and DNA damage. J. Neurosci. 24(40):8720-5.

31.     Angelastro JM, Moon NY, Liu DX, Yang AS, Greene LA, Franke TF (2001). Characterization of a novel isoform of caspase-9 that inhibits apoptosis. J. Biol. Chem. 276(15):12190-200.

32.     Liu DX* and Greene LA (2001).  Neuronal apoptosis at the G1/S cell cycle checkpoint.  Cell Tissue Res. 305(2):217-28.

33.     Liu DX* and Greene LA (2001).  Regulation of neuronal survival and death by E2F-dependent gene repression and derepression.  Neuron 32(3):425-38.

34.     Zhang Y, Wang Z, Liu DX, Pagano M, Ravid K (1998).  Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes. J. Biol. Chem. 273(3):1387-92.

35.     Lu Z, Liu DX, Hornia A, Devonish W, Pagano M, Foster DA (1998). Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation.  Mol. Cell. Biol. 18(2):839-45.

36.     Liu DX* (1990).  DNA regions in the genome of silkworm Attacus ricini contains sequences that structurally and functionally resembles both eukaryotic and prokaryotic promoters.  J. Qingdao Univ.  2(1):88-94.

37.     Liu DX* and He X (1989).  A study on plasmids harbored in thermophilic bacteria – Isolation and characterization of plasmids from Bacillus thermophilus. Chinese J. Biochemistry 5(1):56-60.

38.     Liu DX*, Shen L and Li Z (1989).  Attacus ricini genomic DNA contains regions that can act as prokaryotic promoters.  J. Genetics (Allerton Press, New York, NY.) 15(1):59-72.

39.     Liu DX, Shen L and Li Z (1988).  Cloning and characterization of DNA fragments from the genome of silkworm A. ricini that function as promoters in E. coli.  Acta Genetica Sinica 15(2):102-10.

Book Chapters (*as Corresponding author)

1. Ding Y and Liu DX* (2007).  Cycling to Death: Involvement of Cell Cycle Molecules in Neuronal Apoptosis.  In: Cell Apoptosis Research Advances. Ed. Carter. R. Kattleworth.  Nova Scientific, New York, NY. pp 23-41.

2. Haakensen J, Kester M and Liu DX* (2011). The ATF/CREB family of transcription factors in breast cancer. In: Targeting New Pathways and Cell Death in Breast Cancer.  Ed. Rebecca L. Aft. InTech, ISBN 978-953-51-0145-1, pp. 71-83.

Patent Application

1.         Liu, David X and Li Guangfu, U.S. Patent Application No. 61/149,141:

                          Compositions and Processes Relating to Transcription Factor ATF5

Invited Talks and Presentations (recent)

Southern Research Institute, Birmingham, AL, 2018

Zhejiang Sci-Tech University, Hangzhou, China, 2018

MD Anderson Cancer Center, University of Texas, Houston, TX, 2018

Northeastern State University, Broken Arrow, OK, 2018

Hunter College, City University of New York, New York, NY, 2017

AACR Annual Meeting, Washington DC, 2017

Haixin Group Co., Ltd., Shanghai, China. 2016

Qingdao University Medical College, Qingdao, China. 2015

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. 2015

Washington State University, Cancer and Aging Research Group, Spokane, WA 2014

AACR Annual Meeting, San Diego, CA 2014

Washington State University College of Pharmacy, Spokane, WA 2014

Pennsylvania State University, Hershey, PA 2013

Washington State University, Pullman, WA 2013

North Dakota State University, Fargo, ND 2013

Oakland University, Rochester, MI 2013

Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, 2013

Qingdao University Medical College, Qingdao, China, 2013

Department of Biochemistry and Microbiology, Marshall University, Huntington, VW, 2012

Department of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, 2012

Hunter College, City University of New York, New York, NY, 2011

Translational Research in Mitochondria, Aging, and Disease – TrMAD Symposia, Pittsburgh, PA, 2011

Department of Biochemistry and Molecular Biology, Penn State University, Hershey, PA, 2011

U.S. Department of Defense Breast Cancer Era of Hope Scholars, Orlando, Florida, 2011

Penn State Cancer Institute, Penn State University, Hershey, PA, 2011

Focus of Research

My laboratory studies the molecular and cellular mechanisms that control cell proliferation and survival. Our goal is to identify molecules and signaling pathways that are deregulated in major human diseases as in cancer and to use this knowledge for therapeutic intervention. Recent work from my laboratory and several other laboratories have shown that the activating transcription factor 5 (ATF5) is required for cell survival in cancer cells but is dispensable in non-cancer cells. We also found that ATF5 deficiency significantly reduced tumor burden in PyMT mice. Mechanistically, we demonstrated that ATF5 activates the transcription of Bcl-2 and Egr-1, promoting cell survival and proliferation, and acts as an essential structural component in the centrosome, regulating genomic stability in a cell-cycle-dependent manner. Our studies further indicated that ATF5 is enriched at the midbody and controls cytokinesis. In addition, ATF5 is interdependently activated with NFkB and c-Src in transformed cells, which in turn activates the PI3K/mTOR signaling pathway. Moreover, our data indicated that ATF5 plays an essential role in the transformation-dependent activation of 5’-terminal polypyrimidine track (5’-TOP) genes, whose expression is tightly associated with cell proliferation and survival and is exclusively regulated at translational level. Our work has been published in peer-reviewed journals including Cell, Neuron, Genes&Dev., Molecular Cell, Nature Communications, Oncogene, Cancer Research, among others, and is currently supported by a grant from NCI.